Siddharth Singh, Jithinraj Edakkanambeth Varayil, Edward V. Loftus, Jayant A. Talwalkar – 10 September 2013 – Patients with primary sclerosing cholangitis (PSC) and associated inflammatory bowel disease (IBD) have an increased risk of colorectal cancer (CRC). We estimated the pooled incidence of CRC after liver transplantation (LT) in patients with PSC as well as in a subset of patients with associated IBD (PSC‐IBD). Through a systematic review of major bibliographic databases up to April 1, 2013, we identified cohort studies reporting the incidence of de novo CRC after LT for PSC.

Geoffrey W. McCaughan, Claire M. Vajdic – 10 September 2013

Michael Ramsay – 10 September 2013

Nigel D. Heaton – 10 September 2013

Michael P. Curry – 10 September 2013

Michael R. Charlton – 10 September 2013

Limin Xia, Wenjie Huang, Dean Tian, Lin Zhang, Xingshun Qi, Zhangqian Chen, Xin Shang, Yongzhan Nie, Kaichun Wu – 5 September 2013 – Forkhead box Q1 (FoxQ1) is a master regulator of tumor metastasis. However, the molecular mechanism of FoxQ1 in regulating hepatocellular carcinoma (HCC) metastasis remains unknown. Here we report a novel function for FoxQ1 in modifying the tumor microenvironment to promote HCC metastasis. FoxQ1 expression was an independent and significant risk factor for the recurrence and survival in two independent cohorts totaling 1,002 HCC patients.

Diren Beyoğlu, Jeffrey R. Idle – 5 September 2013

Florian Douam, Viet Loan Dao Thi, Guillemette Maurin, Judith Fresquet, Dimitri Mompelat, Mirjam B. Zeisel, Thomas F. Baumert, François‐Loïc Cosset, Dimitri Lavillette – 4 September 2013 – Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are important mediators for productive cell entry. However, knowledge about their structure, intra‐ or intermolecular dialogs, and conformational changes is scarce, limiting the design of therapeutic strategies targeting E1E2.

Marjon Kerkhof, Pieter Honkoop – 3 September 2013