Validating posttransplant hepatocellular carcinoma recurrence data in the united network for organ sharing database

Mariya L. Samoylova, Jennifer L. Dodge, Eric Vittinghoff, Francis Y. Yao, John Paul Roberts – 27 August 2013 – The Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) database is the most comprehensive collection of liver transplantation data, but the quality of these data with respect to hepatocellular carcinoma (HCC) recurrence has not been well assessed.

Interleukin‐28B and fibrosing cholestatic hepatitis in posttransplant hepatitis C: A case‐control study and literature review

Andres Duarte‐Rojo, Vikram Budhraja, Bart J. Veldt, David D. Goldstein, Kymberly D. Watt, Julie K. Heimbach, John G. McHutchison, Hans L. Tillman, John J. Poterucha, Michael R. Charlton – 27 August 2013 – Chronic hepatitis C (CHC)–related cirrhosis is the leading indication for liver transplantation (LT). However, the recurrence of a hepatitis C virus (HCV) infection after transplantation is universal and is associated with worse outcomes.

Center variation in the use of nonstandardized model for end‐stage liver disease exception points

David S. Goldberg, George Makar, Therese Bittermann, Benjamin French – 27 August 2013 – The Model for End‐Stage Liver Disease (MELD) score is an imperfect prognosticator of waitlist dropout, so transplant centers may apply for exception points to increase a waitlist candidate's priority on the waitlist. Exception applications are categorized as recognized exceptional diagnoses (REDs; eg, hepatocellular carcinoma) and non‐REDs (eg, cholangitis). Although prior work has demonstrated regional variation in the use of exceptions, no work has examined the between‐center variability.

Ductular reaction in hereditary hemochromatosis: The link between hepatocyte senescence and fibrosis progression

Marnie J. Wood, Victoria L. Gadd, Lawrie W. Powell, Grant A. Ramm, Andrew D. Clouston – 26 August 2013 – The development of portal fibrosis following the iron loading of hepatocytes is the first stage of fibrogenesis in hereditary hemochromatosis. In other chronic liver diseases it has been shown that a ductular reaction (DR) appears early, correlates with fibrosis progression, and is a consequence of activation of an alternative pathway of hepatocyte replication. This study was designed to investigate the presence of the DR in hemochromatosis and describe its associations.

Glomerular filtration rate equations for liver‐kidney transplantation in patients with cirrhosis: Validation of current recommendations

Claire Francoz, Mitra K. Nadim, Aurore Baron, Dominique Prié, Corinne Antoine, Jacques Belghiti, Dominique Valla, Richard Moreau, François Durand – 26 August 2013 – Simultaneous liver and kidney transplantation (SLKT) remains the procedure of choice for patients with both endstage liver disease and kidney failure. Stringent guidelines are needed to avoid unnecessary kidney transplantation. A recent consensus meeting proposed criteria based on the Modified Diet in Renal Disease (MDRD)‐6 equation to estimate glomerular filtration rate (GFR).

Evaluation of abdominal ultrasonography mass screening for hepatocellular carcinoma in Taiwan

Yen‐Po Yeh, Tsung‐Hui Hu, Po‐Yuan Cho, Hsiu‐Hsi Chen, Amy Ming‐Fang Yen, Sam Li‐Sheng Chen, Sherry Yueh‐Hsia Chiu, Jean Ching‐Yuan Fann, Wei‐Wen Su, Yi‐Jen Fang, Shih‐Tien Chen, Hsiao‐Ching San, Hung‐Pin Chen, Chao‐Sheng Liao, Changhua Community‐Based Abdominal Ultrasonography Screening Group – 26 August 2013 – Mass screening with abdominal ultrasonography (AUS) has been suggested as a tool to control adult hepatocellular carcinoma (HCC) in individuals, but its efficacy in reducing HCC mortality has never been demonstrated.

Subscribe to