Reciprocal regulation of microRNA‐122 and c‐Myc in hepatocellular cancer: Role of E2F1 and transcription factor dimerization partner 2

Bo Wang, Shu‐hao Hsu, Xinmei Wang, Huban Kutay, Hemant Kumar Bid, Jianhua Yu, Ramesh K. Ganju, Samson T. Jacob, Mariia Yuneva, Kalpana Ghoshal – 28 August 2013 – c‐Myc is a well‐known oncogene frequently up‐regulated in different malignancies, whereas liver‐specific microRNA (miR)‐122, a bona fide tumor suppressor, is down‐regulated in hepatocellular cancer (HCC). Here we explored the underlying mechanism of reciprocal regulation of these two genes.

Glucose sensing O‐GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR)

Wahiba Berrabah, Pierrette Aumercier, Céline Gheeraert, Hélène Dehondt, Emmanuel Bouchaert, Jérémy Alexandre, Maheul Ploton, Claire Mazuy, Sandrine Caron, Anne Tailleux, Jérôme Eeckhoute, Tony Lefebvre, Bart Staels, Philippe Lefebvre – 28 August 2013 – Bile acid metabolism is intimately linked to the control of energy homeostasis and glucose and lipid metabolism. The nuclear receptor farnesoid X receptor (FXR) plays a major role in the enterohepatic cycling of bile acids, but the impact of nutrients on bile acid homeostasis is poorly characterized.

Center variation in the use of nonstandardized model for end‐stage liver disease exception points

David S. Goldberg, George Makar, Therese Bittermann, Benjamin French – 27 August 2013 – The Model for End‐Stage Liver Disease (MELD) score is an imperfect prognosticator of waitlist dropout, so transplant centers may apply for exception points to increase a waitlist candidate's priority on the waitlist. Exception applications are categorized as recognized exceptional diagnoses (REDs; eg, hepatocellular carcinoma) and non‐REDs (eg, cholangitis). Although prior work has demonstrated regional variation in the use of exceptions, no work has examined the between‐center variability.

Interleukin‐28B and fibrosing cholestatic hepatitis in posttransplant hepatitis C: A case‐control study and literature review

Andres Duarte‐Rojo, Vikram Budhraja, Bart J. Veldt, David D. Goldstein, Kymberly D. Watt, Julie K. Heimbach, John G. McHutchison, Hans L. Tillman, John J. Poterucha, Michael R. Charlton – 27 August 2013 – Chronic hepatitis C (CHC)–related cirrhosis is the leading indication for liver transplantation (LT). However, the recurrence of a hepatitis C virus (HCV) infection after transplantation is universal and is associated with worse outcomes.

Validating posttransplant hepatocellular carcinoma recurrence data in the united network for organ sharing database

Mariya L. Samoylova, Jennifer L. Dodge, Eric Vittinghoff, Francis Y. Yao, John Paul Roberts – 27 August 2013 – The Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) database is the most comprehensive collection of liver transplantation data, but the quality of these data with respect to hepatocellular carcinoma (HCC) recurrence has not been well assessed.

Gankyrin promotes tumor growth and metastasis through activation of IL‐6/STAT3 signaling in human cholangiocarcinoma

Tongsen Zheng, Xuehui Hong, Jiabei Wang, Tiemin Pei, Yingjian Liang, Dalong Yin, Ruipeng Song, Xuan Song, Zhaoyang Lu, Shuyi Qi, Jiaren Liu, Boshi Sun, Changming Xie, Shangha Pan, Yuejin Li, Xiaohe Luo, Shuai Li, Xiang Fang, Nishant Bhatta, Hongchi Jiang, Lianxin Liu – 26 August 2013 – Although gankyrin is involved in the tumorigenicity and metastasis of some malignancies, the role of gankyrin in cholangiocarcinoma (CCA) is unclear. In this study we investigated the expression of gankyrin in human CCA tissues and cell lines.

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