Human CD14+CTLA‐4+ regulatory dendritic cells suppress T‐cell response by cytotoxic T‐lymphocyte antigen‐4‐dependent IL‐10 and indoleamine‐2,3‐dioxygenase production in hepatocellular carcinoma

Yanmei Han, Zhubo Chen, Yuan Yang, Zhengping Jiang, Yan Gu, Yangfang Liu, Chuan Lin, Zeya Pan, Yizhi Yu, Minghong Jiang, Weiping Zhou, Xuetao Cao – 19 August 2013 – Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with limited therapeutic options. HCC‐induced immunosuppression often leads to ineffectiveness of immuno‐promoting therapies. Currently, suppressing the suppressors has become the potential strategy for cancer immunotherapy.

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