Long Xu, Wenwei Yin, Rui Sun, Haiming Wei, Zhigang Tian – 8 August 2013 – The liver is considered as a unique lymphoid organ favoring the induction of immune tolerance, rather than immunity. Biologists and clinicians alike have a long‐standing interest in how the liver induces systemic immune tolerance, but the mechanism has not yet been well elucidated.
Edoardo G. Giannini, Vincenzo Savarino – 8 August 2013
Kenichi Morikawa, Jérôme Gouttenoire, Céline Hernandez, Viet Loan Dao Thi, Huong T.L. Tran, Christian M. Lange, Michael T. Dill, Markus H. Heim, Olivier Donzé, François Penin, Manfredo Quadroni, Darius Moradpour – 8 August 2013 – The hepatitis C virus (HCV) NS3‐4A protease is not only an essential component of the viral replication complex and a prime target for antiviral intervention but also a key player in the persistence and pathogenesis of HCV.
Christopher R. Bolen, Siyuan Ding, Michael D. Robek, Steven H. Kleinstein – 8 August 2013 – Despite activating similar signaling cascades, the type I and type III interferons (IFNs) differ in their ability to antagonize virus replication. However, it is not clear whether these cytokines induce unique antiviral states, particularly in the liver, where the clinically important hepatitis B and C viruses cause persistent infection.
Andreas L. Birkenfeld, Gerald I. Shulman – 8 August 2013 – Nonalcoholic fatty liver disease (NAFLD), hepatic insulin resistance, and type 2 diabetes are all strongly associated and are all reaching epidemic proportions. Whether there is a causal link between NAFLD and hepatic insulin resistance is controversial.
Frédéric P. Lemaigre – 8 August 2013
Andreas L. Birkenfeld, Gerald I. Shulman – 8 August 2013 – Nonalcoholic fatty liver disease (NAFLD), hepatic insulin resistance, and type 2 diabetes are all strongly associated and are all reaching epidemic proportions. Whether there is a causal link between NAFLD and hepatic insulin resistance is controversial.
Rohit A. Sinha, Benjamin L. Farah, Brijesh K. Singh, Monowarul M. Siddique, Ying Li, Yajun Wu, Olga R. Ilkayeva, Jessica Gooding, Jianhong Ching, Jin Zhou, Laura Martinez, Sherwin Xie, Boon‐Huat Bay, Scott A. Summers, Christopher B. Newgard, Paul M. Yen – 8 August 2013 – Caffeine is one of the world's most consumed drugs. Recently, several studies showed that its consumption is associated with lower risk for nonalcoholic fatty liver disease (NAFLD), an obesity‐related condition that recently has become the major cause of liver disease worldwide.
Jamuna Karkhanis, Elizabeth C. Verna, Matthew S. Chang, R. Todd Stravitz, Michael Schilsky, William M. Lee, Robert S. Brown, for the Acute Liver Failure Study Group – 8 August 2013 – Drug‐induced and indeterminate acute liver failure (ALF) might be due to an autoimmune‐like hepatitis that is responsive to corticosteroid therapy. The aim of this study was to evaluate whether corticosteroids improve survival in fulminant autoimmune hepatitis, drug‐induced, or indeterminate ALF, and whether this benefit varies according to the severity of illness.
Manfred Wiese, Janett Fischer, Micha Löbermann, Uwe Göbel, Kurt Grüngreiff, Wolfgang Güthoff, Ulrike Kullig, Franziska Richter, Ingolf Schiefke, Hannelore Tenckhoff, Alexander Zipprich, Thomas Berg, Tobias Müller, for the East German HCV Study Group – 8 August 2013 – The natural course of HCV infection remains controversial. The German HCV (1b)‐contaminated anti‐D cohort provides an ideal population to investigate the natural course of HCV infection in a large, homogenous cohort of young women from the date of HCV inoculation.