Treatment of chronic hepatitis C with protease inhibitor‐based therapy after liver transplantation
K. Rajender Reddy, Gregory T. Everson – 31 July 2013
Chronic hepatitis E in an immunocompetent patient: A case report
Priya Grewal, Saleem Kamili, David Motamed – 31 July 2013
Increased hepatic stiffness as consequence of high hepatic afterload in the fontan circulation: A vascular doppler and elastography study
Shaija S. Kutty, Qinghai Peng, David A. Danford, Scott E. Fletcher, Deborah Perry, Geoffrey A. Talmon, Cynthia Scott, John D. Kugler, Kim F. Duncan, Ruben E. Quiros‐Tejeira, Shelby Kutty, the Liver Adult‐Pediatric‐Congenital‐Heart‐Disease Dysfunction Study (LADS) Group – 31 July 2013 – Hepatic dysfunction is a recognized complication after Fontan palliation of congenital heart disease. We sought to quantitatively measure hepatic stiffness and vascular Doppler indices using ultrasound (US) and shear wave elastography (SWE) in a Fontan cohort.
Hepatitis C virus induced up‐regulation of microRNA‐27: A novel mechanism for hepatic steatosis
Ragunath Singaravelu, Ran Chen, Rodney K. Lyn, Daniel M. Jones, Shifawn O'Hara, Yanouchka Rouleau, Jenny Cheng, Prashanth Srinivasan, Neda Nasheri, Rodney S. Russell, D. Lorne Tyrrell, John Paul Pezacki – 29 July 2013 – MicroRNAs (miRNAs) are small RNAs that posttranscriptionally regulate gene expression. Their aberrant expression is commonly linked with diseased states, including hepatitis C virus (HCV) infection. Herein, we demonstrate that HCV replication induces the expression of miR‐27 in cell culture and in vivo HCV infectious models.
Growth arrest and DNA damage 45G down‐regulation contributes to janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma
Li Zhang, Zhaojuan Yang, Aihui Ma, Yulan Qu, Suhua Xia, Dongxu Xu, Chao Ge, Bijun Qiu, Qiang Xia, Jinjun Li, Yongzhong Liu – 29 July 2013 – Growth arrest and DNA damage 45G (GADD45G), a stress sensor with multiple implications in various biological processes, is down‐regulated in a broad spectrum of cancers. However, little is known about the biological effects of GADD45G on hepatocellular carcinoma (HCC) cells and the related mechanisms. In the present study, we found that GADD45G was commonly down‐regulated in oncogene‐transformed mouse liver cells and in human and mouse HCC.
Risk factors for long‐term persistence of serum hepatitis B surface antigen following acute hepatitis B virus infection in Japanese adults
Kiyoaki Ito, Hiroshi Yotsuyanagi, Hiroshi Yatsuhashi, Yoshiyasu Karino, Yasuhiro Takikawa, Takafumi Saito, Yasuji Arase, Fumio Imazeki, Masayuki Kurosaki, Takeji Umemura, Takafumi Ichida, Hidenori Toyoda, Masashi Yoneda, Eiji Mita, Kazuhide Yamamoto, Kojiro Michitaka, Tatsuji Maeshiro, Junko Tanuma, Yasuhito Tanaka, Masaya Sugiyama, Kazumoto Murata, Naohiko Masaki, Masashi Mizokami, the Japanese AHB Study Group – 29 July 2013 – The proportion of patients who progress to chronicity following acute hepatitis B (AHB) varies widely worldwide.
Hepatitis C virus induced up‐regulation of microRNA‐27: A novel mechanism for hepatic steatosis
Ragunath Singaravelu, Ran Chen, Rodney K. Lyn, Daniel M. Jones, Shifawn O'Hara, Yanouchka Rouleau, Jenny Cheng, Prashanth Srinivasan, Neda Nasheri, Rodney S. Russell, D. Lorne Tyrrell, John Paul Pezacki – 29 July 2013 – MicroRNAs (miRNAs) are small RNAs that posttranscriptionally regulate gene expression. Their aberrant expression is commonly linked with diseased states, including hepatitis C virus (HCV) infection. Herein, we demonstrate that HCV replication induces the expression of miR‐27 in cell culture and in vivo HCV infectious models.
Down‐staging of hepatocellular carcinoma via external‐beam radiotherapy with subsequent liver transplantation: A case report
Alan Wigg, Kenneth Hon, Leigh Mosel, Nicole Sladden, Kevin Palumbo – 25 July 2013 – Despite the widespread use of locoregional therapies [radiofrequency ablation and transarterial chemoembolization (TACE)], there is currently a lack of high‐quality evidence supporting their use for hepatocellular carcinoma (HCC) in patients on the liver transplantation (LT) waiting list or requiring down‐staging. Radiotherapy has rarely been used in this setting and has usually been in the form of more complex and less accessible techniques such as proton‐beam and stereotactic body radiation therapy.
Conversion from Prograf to Advagraf in Adolescents with stable liver transplants: Comparative pharmacokinetics and 1‐year follow‐up
Antonio J. Carcas‐Sansuán, Loreto Hierro, Gonzalo N. Almeida‐Paulo, Esteban Frauca, Hoi Yan Tong, Carmen Díaz, Enrique Piñana, Jesús Frías‐Iniesta, Paloma Jara – 25 July 2013 – The recommended dose of Advagraf for conversion from Prograf is considered to be 1:1 on a milligram basis. However, the long‐term equivalence of Prograf and Advagraf has been questioned.
Cyclosporine and tacrolimus have inhibitory effects on toll‐like receptor signaling after liver transplantation
Jessica Howell, Rohit Sawhney, Adam Testro, Narelle Skinner, Paul Gow, Peter Angus, Dilip Ratnam, Kumar Visvanathan – 25 July 2013 – Toll‐like receptors (TLRs) play a key role in transplantation biology. The effect of immunosuppression on TLR function after liver transplantation is unknown. Peripheral blood mononuclear cells (PBMCs) from 113 post–liver transplant patients and 13 healthy controls were stimulated with TLR‐specific ligands [lipopolysaccharide (TLR4), pan‐3‐cys (P3C) (TLR2), Poly (I:C) (PIC) (TLR3), R848 (TLR7/8), and CpG (TLR9)] for 24 hours.