Anne Frentzen, Anggakusuma, Engin Gürlevik, Kathrin Hueging, Sarah Knocke, Corinne Ginkel, Richard J.P. Brown, Markus Heim, Michael T. Dill, Andrea Kröger, Ulrich Kalinke, Lars Kaderali, Florian Kuehnel, Thomas Pietschmann – 19 July 2013 – Only humans and chimpanzees are susceptible to chronic infection by hepatitis C virus (HCV). The restricted species tropism of HCV is determined by distinct host factor requirements at different steps of the viral life cycle. In addition, effective innate immune targeting precludes efficient propagation of HCV in nonhuman cells.

Ana Ruiz, Sara Lemoinne, Fabrice Carrat, Christophe Corpechot, Olivier Chazouillères, Lionel Arrivé – 15 July 2013 – Magnetic resonance imaging (MRI) with magnetic resonance cholangiography (MRC) has become the radiologic standard of reference for diagnosis of primary sclerosing cholangitis (PSC). However, natural history of radiologic features of PSC is poorly known. In the current study, we aimed at analyzing the course of PSC using three‐dimensional (3D) MRC and liver MRI to find predictive radiologic features of progression.

Ana Ruiz, Sara Lemoinne, Fabrice Carrat, Christophe Corpechot, Olivier Chazouillères, Lionel Arrivé – 15 July 2013 – Magnetic resonance imaging (MRI) with magnetic resonance cholangiography (MRC) has become the radiologic standard of reference for diagnosis of primary sclerosing cholangitis (PSC). However, natural history of radiologic features of PSC is poorly known. In the current study, we aimed at analyzing the course of PSC using three‐dimensional (3D) MRC and liver MRI to find predictive radiologic features of progression.

Victoria Geenes, Lucy C. Chappell, Paul T. Seed, Philip J. Steer, Marian Knight, Catherine Williamson – 15 July 2013 – Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy‐specific liver disease, characterized by maternal pruritus and raised serum bile acids. Our objectives were to describe the epidemiology and pregnancy complications associated with severe ICP and to test the hypothesis that adverse perinatal outcomes are increased in these women.

Annalisa Petrelli, Andrea Perra, Davide Cora, Pia Sulas, Silvia Menegon, Claudia Manca, Cristina Migliore, Marta Anna Kowalik, Giovanna Maria Ledda‐Columbano, Silvia Giordano, Amedeo Columbano – 15 July 2013 – Studies on gene and/or microRNA (miRNA) dysregulation in the early stages of hepatocarcinogenesis are hampered by the difficulty of diagnosing early lesions in humans. Experimental models recapitulating human hepatocellular carcinoma (HCC) are then used to perform this analysis.

Jeffrey Campsen, Michael Zimmerman, James Trotter, Johnny Hong, Chris Freise, Robert Brown, Andrew Cameron, Mark Ghobrial, Igal Kam, Ronald Busuttil, Sammy Saab, Curtis Holt, Jean Emond, Jessica Stiles, Thresiamma Lukose, Matthew Chang, Goran Klintmalm – 15 July 2013 – Reinfection with hepatitis B virus (HBV) after liver transplantation (LT) may favor the recurrence of hepatocellular carcinoma (HCC), and combination therapy with hepatitis B immunoglobulin (HBIG) and nucleoside/nucleotide analogues may reduce HBV recurrence after LT.

Andrea Mancuso – 15 July 2013

Irina Tikhanovich, Sudhakiranmayi Kuravi, Roosevelt V. Campbell, Kusum K. Kharbanda, Antonio Artigues, Maria T. Villar, Steven A. Weinman – 15 July 2013 – Hepatitis C virus (HCV) infection produces chronic liver injury that is significantly exacerbated by alcohol consumption. While multiple mechanisms contribute to this synergy, a viral‐induced loss of antioxidant responses has been shown to play an important role.

Edoardo G. Giannini, Vincenzo Savarino – 15 July 2013

Gisa Gerold, Thomas Pietschmann – 15 July 2013