Neil Mehta, Ryutaro Hirose – 19 August 2013 – Watch a video presentation of this article

JP Norvell, Josh Levitsky – 19 August 2013 – Watch a video presentation of this article

Oren K. Fix – 19 August 2013 – Watch a video presentation of this article

Federico G. Villamil, Fernando M. Cairo – 19 August 2013 – Watch a video presentation of this article

Yanmei Han, Zhubo Chen, Yuan Yang, Zhengping Jiang, Yan Gu, Yangfang Liu, Chuan Lin, Zeya Pan, Yizhi Yu, Minghong Jiang, Weiping Zhou, Xuetao Cao – 19 August 2013 – Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with limited therapeutic options. HCC‐induced immunosuppression often leads to ineffectiveness of immuno‐promoting therapies. Currently, suppressing the suppressors has become the potential strategy for cancer immunotherapy.

Samuele Minicis, Chiara Rychlicki, Laura Agostinelli, Stefania Saccomanno, Cinzia Candelaresi, Luciano Trozzi, Eleonora Mingarelli, Bruna Facinelli, Gloria Magi, Claudio Palmieri, Marco Marzioni, Antonio Benedetti, Gianluca Svegliati‐Baroni – 19 August 2013 – Nonalcoholic fatty liver disease (NAFLD) may lead to hepatic fibrosis. Dietary habits affect gut microbiota composition, whereas endotoxins produced by Gram‐negative bacteria stimulate hepatic fibrogenesis. However, the mechanisms of action and the potential effect of microbiota in the liver are still unknown.

Toshana L. Foster, Gary S. Thompson, Arnout P. Kalverda, Jayakanth Kankanala, Matthew Bentham, Laura F. Wetherill, Joseph Thompson, Amy M. Barker, Dean Clarke, Marko Noerenberg, Arwen R. Pearson, David J. Rowlands, Steven W. Homans, Mark Harris, Richard Foster, Stephen Griffin – 12 August 2013 – Current interferon‐based therapy for hepatitis C virus (HCV) infection is inadequate, prompting a shift toward combinations of direct‐acting antivirals (DAA) with the first protease‐targeted drugs licensed in 2012.

Dalbir S. Sandhu, Esha Baichoo, Lewis R. Roberts – 12 August 2013 – Fibroblast growth factors, or FGFs, are a large family of polypeptide cytokines exhibiting a pleiotropy of functions, from cell growth to angiogenesis, wound healing, and tissue repair. This review broadly covers the genetics and protein expression of the FGF family members and the signaling pathways involved in FGF‐mediated growth regulation. We emphasize the role of FGFs in the pathogenesis of hepatocellular carcinoma (HCC), including their effects on regulation of the tumor microenvironment and angiogenesis.

Dalbir S. Sandhu, Esha Baichoo, Lewis R. Roberts – 12 August 2013 – Fibroblast growth factors, or FGFs, are a large family of polypeptide cytokines exhibiting a pleiotropy of functions, from cell growth to angiogenesis, wound healing, and tissue repair. This review broadly covers the genetics and protein expression of the FGF family members and the signaling pathways involved in FGF‐mediated growth regulation. We emphasize the role of FGFs in the pathogenesis of hepatocellular carcinoma (HCC), including their effects on regulation of the tumor microenvironment and angiogenesis.

John F. Renz – 12 August 2013