Relationship between the histological appearance of the portal vein and development of ischemic‐type biliary lesions after liver transplantation

Waqar R. R. Farid, Jeroen Jonge, Pieter E. Zondervan, Ahmet Demirkiran, Herold J. Metselaar, Hugo W. Tilanus, Ron W. F. Bruin, Luc J. W. Laan, Geert Kazemier – 10 July 2013 – Ischemic‐type biliary lesions (ITBLs) are a major cause of morbidity after liver transplantation (LT). Their assumed underlying pathophysiological mechanism is ischemia/reperfusion injury of the biliary tree, in which the portal circulation has been proposed recently to have a role.

Repopulation of the fibrotic/cirrhotic rat liver by transplanted hepatic stem/progenitor cells and mature hepatocytes

Mladen I. Yovchev, Yuhua Xue, David A. Shafritz, Joseph Locker, Michael Oertel – 10 July 2013 – Considerable progress has been made in developing antifibrotic agents and other strategies to treat liver fibrosis; however, significant long‐term restoration of functional liver mass has not yet been achieved. Therefore, we investigated whether transplanted hepatic stem/progenitor cells can effectively repopulate the liver with advanced fibrosis/cirrhosis.

The insulin receptor translocates to the nucleus to regulate cell proliferation in liver

Maria J. Amaya, André G. Oliveira, Erika S. Guimarães, Marisa C.F. Casteluber, Sandhra M. Carvalho, Lidia M. Andrade, Mauro C.X. Pinto, Albert Mennone, Cleida A. Oliveira, Rodrigo R. Resende, Gustavo B. Menezes, Michael H. Nathanson, M. Fatima Leite – 9 July 2013 – Insulin's metabolic effects in the liver are widely appreciated, but insulin's ability to act as a hepatic mitogen is less well understood.

Segment 4 architecture and proposed parenchyma‐wise technique for Ex vivo graft procurement and implantation

Ramadan M. Gharbawy, Bakr M. Nour – 9 July 2013 – A parenchyma‐wise technique for the ex vivo procurement of segment 4 (S4) grafts, based on the detailed architecture of the segment, is proposed. Eighteen normal, fresh livers from adult cadavers were injected differentially with colored latex; dissection casts were prepared; and the intricate architecture of S4 was studied.

Long‐term medical management of the pediatric patient after liver transplantation: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation

Deirdre A. Kelly, John C. Bucuvalas, Estella M. Alonso, Saul J. Karpen, Upton Allen, Michael Green, Douglas Farmer, Eyal Shemesh, Ruth A. McDonald – 9 July 2013

Endogenous signal transducer and activator of transcription 3 is required for the protection of hepatocytes against warm ischemia/reperfusion injury

Lucy Xi Lou, Tadahiro Uemura, Haresh Mani, Chen Yang, Weiyi Li, Zakiyah Kadry, Samuel Shao‐Min Zhang – 9 July 2013 – Warm ischemia/reperfusion (I/R) is a common clinical problem during liver transplantation and liver resection. Warm ischemia also occurs during trauma and shock. However, there is still no safe and promising strategy for protecting the liver from I/R injury. Signal transducer and activator of transcription 3 (STAT3) is a major immediate response molecule for protecting cell survival.

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

Jinghong Wan, Merieme Benkdane, Fatima Teixeira‐Clerc, Stéphanie Bonnafous, Alexandre Louvet, Fouad Lafdil, Françoise Pecker, Albert Tran, Philippe Gual, Ariane Mallat, Sophie Lotersztajn, Catherine Pavoine – 6 July 2013 – Alcoholic and nonalcoholic fatty liver disease (ALD and NAFLD) are the predominant causes of liver‐related mortality in Western countries. We have shown that limiting classical (M1) Kupffer cell (KC) polarization reduces alcohol‐induced liver injury. Herein, we investigated whether favoring alternatively activated M2 KCs may protect against ALD and NAFLD.

Subscribe to