Alpha‐fetoprotein and modified response evaluation criteria in Solid Tumors progression after locoregional therapy as predictors of hepatocellular cancer recurrence and death after transplantation

Quirino Lai, Alfonso W. Avolio, Ivo Graziadei, Gerd Otto, Massimo Rossi, Giuseppe Tisone, Pierre Goffette, Wolfgang Vogel, Michael B. Pitton, Jan Lerut, on behalf of the European Hepatocellular Cancer Liver Transplant Study Group – 19 July 2013 – Locoregional therapy (LRT) is being increasingly used for the management of hepatocellular cancer (HCC) in patients listed for liver transplantation (LT). Although several selection criteria have been developed, stratifications of survival according to the pathology of explanted livers and pre‐LT LRT are lacking.

Regulation of FOXO3 by phosphorylation and methylation in hepatitis C virus infection and alcohol exposure

Irina Tikhanovich, Sudhakiranmayi Kuravi, Roosevelt V. Campbell, Kusum K. Kharbanda, Antonio Artigues, Maria T. Villar, Steven A. Weinman – 15 July 2013 – Hepatitis C virus (HCV) infection produces chronic liver injury that is significantly exacerbated by alcohol consumption. While multiple mechanisms contribute to this synergy, a viral‐induced loss of antioxidant responses has been shown to play an important role.

Liver transplantation for hepatitis B liver disease and concomitant hepatocellular carcinoma in the United States With hepatitis B immunoglobulin and nucleoside/nucleotide analogues

Jeffrey Campsen, Michael Zimmerman, James Trotter, Johnny Hong, Chris Freise, Robert Brown, Andrew Cameron, Mark Ghobrial, Igal Kam, Ronald Busuttil, Sammy Saab, Curtis Holt, Jean Emond, Jessica Stiles, Thresiamma Lukose, Matthew Chang, Goran Klintmalm – 15 July 2013 – Reinfection with hepatitis B virus (HBV) after liver transplantation (LT) may favor the recurrence of hepatocellular carcinoma (HCC), and combination therapy with hepatitis B immunoglobulin (HBIG) and nucleoside/nucleotide analogues may reduce HBV recurrence after LT.

MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC)

Annalisa Petrelli, Andrea Perra, Davide Cora, Pia Sulas, Silvia Menegon, Claudia Manca, Cristina Migliore, Marta Anna Kowalik, Giovanna Maria Ledda‐Columbano, Silvia Giordano, Amedeo Columbano – 15 July 2013 – Studies on gene and/or microRNA (miRNA) dysregulation in the early stages of hepatocarcinogenesis are hampered by the difficulty of diagnosing early lesions in humans. Experimental models recapitulating human hepatocellular carcinoma (HCC) are then used to perform this analysis.

Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: A prospective population‐based case‐control study

Victoria Geenes, Lucy C. Chappell, Paul T. Seed, Philip J. Steer, Marian Knight, Catherine Williamson – 15 July 2013 – Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy‐specific liver disease, characterized by maternal pruritus and raised serum bile acids. Our objectives were to describe the epidemiology and pregnancy complications associated with severe ICP and to test the hypothesis that adverse perinatal outcomes are increased in these women.

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