Ductular reaction in hereditary hemochromatosis: The link between hepatocyte senescence and fibrosis progression
Marnie J. Wood, Victoria L. Gadd, Lawrie W. Powell, Grant A. Ramm, Andrew D. Clouston – 26 August 2013 – The development of portal fibrosis following the iron loading of hepatocytes is the first stage of fibrogenesis in hereditary hemochromatosis. In other chronic liver diseases it has been shown that a ductular reaction (DR) appears early, correlates with fibrosis progression, and is a consequence of activation of an alternative pathway of hepatocyte replication. This study was designed to investigate the presence of the DR in hemochromatosis and describe its associations.