Concurrent deletion of cyclin E1 and cyclin‐dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice

Wei Hu, Yulia A. Nevzorova, Ute Haas, Nives Moro, Piotr Sicinski, Yan Geng, Mariano Barbacid, Christian Trautwein, Christian Liedtke – 20 June 2013 – The liver has a strong regenerative capacity. After injury, quiescent hepatocytes can reenter the mitotic cell cycle to restore tissue homeostasis. This G0/G1‐S cell‐cycle transition of primed hepatocytes is regulated by complexes of cyclin‐dependent kinase 2 (Cdk2) with E‐type cyclins (CcnE1 or CcnE2). However, single genetic ablation of either E‐cyclin or Cdk2 does not affect overall liver regeneration.

Adaptation of iron transport and metabolism to acute high‐altitude hypoxia in mountaineers

Oliver Goetze, Johannes Schmitt, Kerstin Spliethoff, Igor Theurl, Günter Weiss, Dorine W. Swinkels, Harold Tjalsma, Marco Maggiorini, Pierre Krayenbühl, Monika Rau, Heiko Fruehauf, Kacper A. Wojtal, Beat Müllhaupt, Michael Fried, Max Gassmann, Thomas Lutz, Andreas Geier – 20 June 2013 – Human iron homeostasis is regulated by intestinal iron transport, hepatic hepcidin release, and signals from pathways that consume or supply iron.

Subscribe to