Population health impact and cost‐effectiveness of monitoring inactive chronic hepatitis B and treating eligible patients in Shanghai, China

Mehlika Toy, Joshua A. Salomon, Hao Jiang, Honglian Gui, Hui Wang, Jiangshe Wang, Jan Hendrik Richardus, Qing Xie – 19 December 2013 – Inactive chronic hepatitis B (CHB) carriers make up the largest group of hepatitis B virus‐infected patients, and China bears the largest total CHB burden of any country. We therefore assessed the population health impact and cost‐effectiveness of a strategy of lifelong monitoring for inactive CHB and treatment of eligible patients in Shanghai, China.

Fate of abstracts presented at the 2004‐2008 International Liver Transplantation Society meetings

Patrick J. Hackett, Marina Guirguis, Nozomi Sakai, Tetsuro Sakai – 19 December 2013 – Only 20.5% to 61.6% of abstracts presented at biomedical meetings are subsequently published as full‐length articles. The aim of this study was to analyze the abstract‐to‐publication rate of International Liver Transplantation Society (ILTS) meeting abstracts. Abstracts presented at 5 consecutive annual ILTS meetings (2004‐2008) were included to ensure a minimum follow‐up period of 4 years.

Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T‐cell apoptosis

Simon C. Afford, Elizabeth H. Humphreys, Danielle T. Reid, Clare L. Russell, Vanessa M. Banz, Ye Oo, Tina Vo, Craig Jenne, David H. Adams, Bertus Eksteen – 12 December 2013 – Chronic hepatitis occurs when effector lymphocytes are recruited to the liver from blood and retained in tissue to interact with target cells, such as hepatocytes or bile ducts (BDs). Vascular cell adhesion molecule 1 (VCAM‐1; CD106), a member of the immunoglobulin superfamily, supports leukocyte adhesion by binding α4β1 integrins and is critical for the recruitment of monocytes and lymphocytes during inflammation.

SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling

Juan L. García‐Rodríguez, Lucía Barbier‐Torres, Sara Fernández‐Álvarez, Virginia Gutiérrez‐de Juan, María J. Monte, Emina Halilbasic, Daniel Herranz, Luis Álvarez, Patricia Aspichueta, Jose J.G. Marín, Michael Trauner, Jose M. Mato, Manuel Serrano, Naiara Beraza, María Luz Martínez‐Chantar – 12 December 2013 – Sirtuin1 (SIRT1) regulates central metabolic functions such as lipogenesis, protein synthesis, gluconeogenesis, and bile acid (BA) homeostasis through deacetylation. Here we describe that SIRT1 tightly controls the regenerative response of the liver.

Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4

Edward J. Andress, Michael Nicolaou, Marta R. Romero, Sandhia Naik, Peter H. Dixon, Catherine Williamson, Kenneth J. Linton – 12 December 2013 – ABCB4 flops phosphatidylcholine into the bile canaliculus to protect the biliary tree from the detergent activity of bile salts. Homozygous‐null ABCB4 mutations cause the childhood liver disease, progressive familial intrahepatic cholestasis, but cause and effect is less clear, with many missense mutations linked to less severe cholestatic diseases.

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