Current management of uncomplicated ascites
Paolo Angeli – 21 June 2013 – Watch a video presentation of this article
When to use renal replacement therapy and bioartificial support for renal failure in patients with cirrhosis
Vincenzo Morabito, Gilnardo Novelli, Rajiv Jalan – 21 June 2013 – Watch a video presentation of this article
Current management of uncomplicated ascites
Paolo Angeli – 21 June 2013 – Watch a video presentation of this article
Relationship between systemic hemodynamics, renal dysfunction, and fluid retention in cirrhosis
Vicente Arroyo, Javier Fernández – 21 June 2013 – Watch a video presentation of this article
Concurrent deletion of cyclin E1 and cyclin‐dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice
Wei Hu, Yulia A. Nevzorova, Ute Haas, Nives Moro, Piotr Sicinski, Yan Geng, Mariano Barbacid, Christian Trautwein, Christian Liedtke – 20 June 2013 – The liver has a strong regenerative capacity. After injury, quiescent hepatocytes can reenter the mitotic cell cycle to restore tissue homeostasis. This G0/G1‐S cell‐cycle transition of primed hepatocytes is regulated by complexes of cyclin‐dependent kinase 2 (Cdk2) with E‐type cyclins (CcnE1 or CcnE2). However, single genetic ablation of either E‐cyclin or Cdk2 does not affect overall liver regeneration.
Prothrombotic factors and nonalcoholic fatty liver disease: An additional link to cardiovascular risk?
Francisco Barrera, Jacob George – 20 June 2013
Adaptation of iron transport and metabolism to acute high‐altitude hypoxia in mountaineers
Oliver Goetze, Johannes Schmitt, Kerstin Spliethoff, Igor Theurl, Günter Weiss, Dorine W. Swinkels, Harold Tjalsma, Marco Maggiorini, Pierre Krayenbühl, Monika Rau, Heiko Fruehauf, Kacper A. Wojtal, Beat Müllhaupt, Michael Fried, Max Gassmann, Thomas Lutz, Andreas Geier – 20 June 2013 – Human iron homeostasis is regulated by intestinal iron transport, hepatic hepcidin release, and signals from pathways that consume or supply iron.
Expanding access to hepatitis C virus care: A call to deconstruct individualized therapy
Andrew Aronsohn, Donald Jensen – 20 June 2013
Dysfunctional CD39POS regulatory T cells and aberrant control of T‐helper type 17 cells in autoimmune hepatitis
Charlotte R. Grant, Rodrigo Liberal, Beth S. Holder, John Cardone, Yun Ma, Simon C. Robson, Giorgina Mieli‐Vergani, Diego Vergani, Maria Serena Longhi – 20 June 2013 – Autoimmune hepatitis (AIH) is an important cause of severe liver disease and is associated with both quantitative and qualitative regulatory T‐cell (Treg) impairments. Tregs express CD39, an ectonucleotidase responsible for extracellular nucleotide hydrolysis, culminating in the production of immunosuppressive adenosine.
Hepatic‐specific lipin‐1 deficiency exacerbates experimental alcohol‐induced steatohepatitis in mice
Ming Hu, Huquan Yin, Mayurranjan S. Mitra, Xiaomei Liang, Joanne M. Ajmo, Karim Nadra, Roman Chrast, Brian N. Finck, Min You – 20 June 2013 – Lipin‐1 regulates lipid metabolism by way of its function as an enzyme in the triglyceride synthesis pathway and as a transcriptional coregulatory protein and is highly up‐regulated in alcoholic fatty liver disease. In the present study, using a liver‐specific lipin‐1‐deficient (lipin‐1LKO) mouse model, we aimed to investigate the functional role of lipin‐1 in the development of alcoholic steatohepatitis and explore the underlying mechanisms.