Adaptation of iron transport and metabolism to acute high‐altitude hypoxia in mountaineers

Oliver Goetze, Johannes Schmitt, Kerstin Spliethoff, Igor Theurl, Günter Weiss, Dorine W. Swinkels, Harold Tjalsma, Marco Maggiorini, Pierre Krayenbühl, Monika Rau, Heiko Fruehauf, Kacper A. Wojtal, Beat Müllhaupt, Michael Fried, Max Gassmann, Thomas Lutz, Andreas Geier – 20 June 2013 – Human iron homeostasis is regulated by intestinal iron transport, hepatic hepcidin release, and signals from pathways that consume or supply iron.

Concurrent deletion of cyclin E1 and cyclin‐dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice

Wei Hu, Yulia A. Nevzorova, Ute Haas, Nives Moro, Piotr Sicinski, Yan Geng, Mariano Barbacid, Christian Trautwein, Christian Liedtke – 20 June 2013 – The liver has a strong regenerative capacity. After injury, quiescent hepatocytes can reenter the mitotic cell cycle to restore tissue homeostasis. This G0/G1‐S cell‐cycle transition of primed hepatocytes is regulated by complexes of cyclin‐dependent kinase 2 (Cdk2) with E‐type cyclins (CcnE1 or CcnE2). However, single genetic ablation of either E‐cyclin or Cdk2 does not affect overall liver regeneration.

Impact of the center on graft failure after liver transplantation

Sumeet K. Asrani, W. Ray Kim, Erick B. Edwards, Joseph J. Larson, Gabriel Thabut, Walter K. Kremers, Terry M. Therneau, Julie Heimbach – 19 June 2013 – The hospital at which liver transplantation (LT) is performed has a substantial impact on post‐LT outcomes. Center‐specific outcome data are closely monitored not only by the centers themselves but also by patients and government regulatory agencies.

Trial of complete weaning from immunosuppression for liver transplant recipients: Factors predictive of tolerance

Rocío García Garza, Pablo Sarobe, Juana Merino, Juan J. Lasarte, Delia D'Avola, Virginia Belsue, José A. Delgado, Leyre Silva, Mercedes Iñarrairaegui, Bruno Sangro, Jesus J. Sola, Fernando Pardo, Jorge Quiroga, J. Ignacio Herrero – 19 June 2013 – Recipients of liver transplantation (LT) may develop immunological tolerance. Factors predictive of tolerance are not clearly understood.

Decadal analysis of deceased organ donation in Spain and the United States linking an increased donation rate and the utilization of older donors

Jeff Halldorson, John Paul Roberts – 19 June 2013 – After the foundation of the National Transplant Organization, Spanish rates of deceased donor donation rapidly outpaced US growth over the decade from 1989 to 1999. An analysis of the following decade, 1999‐2009, demonstrated a markedly flattened growth curve for Spanish deceased donor organ procurement, which increased only 2.4% from 33.6 to 34.4 donors per million population (pmp). In comparison, over the same decade in the United States, the rate of deceased donation increased from 20.9 to 26.3 donors pmp (25.8%).

Long‐term deleterious effects of aortohepatic conduits in primary liver transplantation: Proceed with caution

Taizo Hibi, Seigo Nishida, David M. Levi, Daisuke Sugiyama, Kyota Fukazawa, Akin Tekin, Ji Fan, Gennaro Selvaggi, Phillip Ruiz, Andreas G. Tzakis – 19 June 2013 – Aortohepatic conduits provide a vital alternative for graft arterialization during liver transplantation. Conflicting results exist with respect to the rates of comorbidities, and long‐term survival data on primary grafts are lacking.

Preformed class II donor‐specific antibodies are associated with an increased risk of early rejection after liver transplantation

Jacqueline G. O'Leary, Hugo Kaneku, Linda W. Jennings, Nubia Bañuelos, Brian M. Susskind, Paul I. Terasaki, Göran B. Klintmalm – 18 June 2013 – Preformed donor‐specific human leukocyte antigen antibodies (DSAs) are considered a contraindication to the transplantation of most solid organs other than the liver. Conflicting data currently exist on the importance of preformed DSAs in rejection and patient survival after liver transplantation (LT).

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