Trial of complete weaning from immunosuppression for liver transplant recipients: Factors predictive of tolerance

Rocío García Garza, Pablo Sarobe, Juana Merino, Juan J. Lasarte, Delia D'Avola, Virginia Belsue, José A. Delgado, Leyre Silva, Mercedes Iñarrairaegui, Bruno Sangro, Jesus J. Sola, Fernando Pardo, Jorge Quiroga, J. Ignacio Herrero – 19 June 2013 – Recipients of liver transplantation (LT) may develop immunological tolerance. Factors predictive of tolerance are not clearly understood.

Impact of the center on graft failure after liver transplantation

Sumeet K. Asrani, W. Ray Kim, Erick B. Edwards, Joseph J. Larson, Gabriel Thabut, Walter K. Kremers, Terry M. Therneau, Julie Heimbach – 19 June 2013 – The hospital at which liver transplantation (LT) is performed has a substantial impact on post‐LT outcomes. Center‐specific outcome data are closely monitored not only by the centers themselves but also by patients and government regulatory agencies.

Quality of life is significantly impaired in long‐term survivors of acute liver failure and particularly in acetaminophen‐overdose patients

Amol S. Rangnekar, Caitlyn Ellerbe, Valerie Durkalski, Brendan McGuire, William M. Lee, Robert J. Fontana – 18 June 2013 – Functional outcomes for long‐term survivors of acute liver failure (ALF) are not well characterized. The aim of this prospective study was to determine health‐related quality of life in long‐term adult ALF survivors. Acute Liver Failure Study Group registry participants completed the Centers for Disease Control and Prevention Health‐Related Quality of Life 14 and Short Form 36 (SF‐36) questionnaires at 1‐ and/or 2‐year follow‐up study visits.

Preformed class II donor‐specific antibodies are associated with an increased risk of early rejection after liver transplantation

Jacqueline G. O'Leary, Hugo Kaneku, Linda W. Jennings, Nubia Bañuelos, Brian M. Susskind, Paul I. Terasaki, Göran B. Klintmalm – 18 June 2013 – Preformed donor‐specific human leukocyte antigen antibodies (DSAs) are considered a contraindication to the transplantation of most solid organs other than the liver. Conflicting data currently exist on the importance of preformed DSAs in rejection and patient survival after liver transplantation (LT).

Calcineurin Inhibitor–Free Mycophenolate Mofetil/Sirolimus Maintenance in Liver Transplantation: The Randomized Spare‐the‐Nephron Trial

Lewis Teperman, Dilip Moonka, Anthony Sebastian, Linda Sher, Paul Marotta, Christopher Marsh, Baburao Koneru, John Goss, Dennis Preston, John P. Roberts, Spare‐the‐Nephron Trial Liver Transplantation Study Group – 15 June 2013 – Mycophenolate mofetil (MMF) and sirolimus (SRL) have been used for calcineurin inhibitor (CNI) minimization to reduce nephrotoxicity following liver transplantation.

Improved Waiting‐List Outcomes in Argentina After the Adoption of a Model for End‐Stage Liver Disease–Based Liver Allocation Policy

Nora Gabriela Cejas, Federico G. Villamil, Javier C. Lendoire, Viviana Tagliafichi, Arturo Lopez, Daniela Hansen Krogh, Carlos A. Soratti, Liliana Bisigniano – 15 June 2013 – In July 2005, Argentina became the first country after the United States to introduce the Model for End‐Stage Liver Disease (MELD) for organ allocation. In this study, we investigated waiting‐list (WL) outcomes (n = 3272) and post–liver transplantation (LT) survival in 2 consecutive periods of 5 years before and after the implementation of a MELD‐based allocation policy.

Liver transplantation normalizes serum hepcidin level and cures iron metabolism alterations in HFE hemochromatosis

Edouard Bardou‐Jacquet, Julie Philip, Richard Lorho, Martine Ropert, Marianne Latournerie, Pauline Houssel‐Debry, Dominique Guyader, Olivier Loréal, Karim Boudjema, Pierre Brissot – 14 June 2013 – Defects in human hemochromatosis protein (HFE) cause iron overload due to reduced hepatic hepcidin secretion. Liver transplantation (LT) is a key treatment for potential complications from HFE‐related hereditary hemochromatosis (HH). This study evaluated hepcidin secretion and iron burden after LT to elucidate HH pathophysiology.

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