Laurent Sulpice, Michel Rayar, Mireille Desille, Bruno Turlin, Alain Fautrel, Eveline Boucher, Francisco Llamas‐Gutierrez, Bernard Meunier, Karim Boudjema, Bruno Clément, Cédric Coulouarn – 14 June 2013 – Intrahepatic cholangiocarcinoma (ICC) is the second most common type of primary cancer in the liver. ICC is an aggressive cancer with poor prognosis and limited therapeutic strategies. The identification of new drug targets and prognostic biomarkers is an important clinical challenge for ICC. The presence of an abundant stroma is a histological hallmark of ICC.

Ian A. Rowe, Sukhdeep K. Galsinh, Garrick K. Wilson, Richard Parker, Sarah Durant, Catalin Lazar, Norica Branza‐Nichita, Roy Bicknell, David H. Adams, Peter Balfe, Jane A. McKeating – 14 June 2013 – Hepatitis C virus (HCV) is a major cause of global morbidity, causing chronic liver injury that can progress to cirrhosis and hepatocellular carcinoma. The liver is a large and complex organ containing multiple cell types, including hepatocytes, sinusoidal endothelial cells (LSEC), Kupffer cells, and biliary epithelial cells.

Imir G. Metushi, Corron Sanders, The Acute Liver Study Group, William M. Lee, Jack Uetrecht – 14 June 2013 – Isoniazid (INH)‐induced hepatotoxicity remains one of the most common causes of drug‐induced idiosyncratic liver injury and liver failure. This form of liver injury is not believed to be immune‐mediated because it is not usually associated with fever or rash, does not recur more rapidly on rechallenge, and previous studies have failed to identify anti‐INH antibodies (Abs). In this study, we found Abs present in sera of 15 of 19 cases of INH‐induced liver failure.

Jens Bukh, Robert E. Lanford, Robert H. Purcell – 14 June 2013

Pablo Quintero, Marco Arrese – 14 June 2013

Rineke H.G. Steenbergen, Michael A. Joyce, Bradley S. Thomas, Daniel Jones, John Law, Rodney Russell, Michael Houghton, D. Lorne Tyrrell – 14 June 2013 – In this study, we differentiated the human hepatoma cell line Huh7.5 by supplementing tissue culture media with human serum (HS) and examined the production of hepatitis C virus (HCV) by these cells. We compared the standard tissue culture protocol, using media supplemented with 10% fetal bovine serum (FBS), to media supplemented with 2% HS.

Ian A. Rowe, Sukhdeep K. Galsinh, Garrick K. Wilson, Richard Parker, Sarah Durant, Catalin Lazar, Norica Branza‐Nichita, Roy Bicknell, David H. Adams, Peter Balfe, Jane A. McKeating – 14 June 2013 – Hepatitis C virus (HCV) is a major cause of global morbidity, causing chronic liver injury that can progress to cirrhosis and hepatocellular carcinoma. The liver is a large and complex organ containing multiple cell types, including hepatocytes, sinusoidal endothelial cells (LSEC), Kupffer cells, and biliary epithelial cells.

Stefan Stender, Børge G. Nordestgaard, Anne Tybjærg‐Hansen – 14 June 2013 – Elevated body mass index (BMI) is associated with an increased risk of gallstone disease. Whether this reflects a causal association is unknown. Using a Mendelian randomization approach, we studied 77,679 individuals from the general population. Of these, 4,106 developed symptomatic gallstone disease during up to 34 years of follow‐up. Subjects were genotyped for three common variants known to associate with BMI: FTO(rs9939609); MC4R(rs17782313); and TMEM18(rs6548238).

Christopher Koh, Xiongce Zhao, Niharika Samala, Sasan Sakiani, T. Jake Liang, Jayant A. Talwalkar – 14 June 2013 – The American Association for the Study of Liver Diseases (AASLD) practice guidelines provide recommendations in diagnosing and managing patients with liver disease from available scientific evidence in combination with expert consensus opinions. The aim was to systematically review the evolution of recommendations from AASLD guidelines and identify gaps limiting the evidence‐based foundations of these guidelines.

Josh Levitsky – 14 June 2013