T‐cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis

Jiacheng Bi, Qing Zhang, Dan Liang, Lei Xiong, Haiming Wei, Rui Sun, Zhigang Tian – 9 December 2013 – Uncontrolled natural killer (NK) cell activation during the early response to acute viral infection can lead to severe immunopathology, and the mechanisms NK cells use to achieve self‐tolerance in such contexts are currently unclear. Here, NK cells up‐regulated a coinhibitory receptor, T‐cell Ig and ITIM domain (TIGIT), during challenge with the viral double‐stranded RNA (dsRNA) analog poly I:C.

Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell‐cycle control and apoptosis

Ulrike A. Köhler, Svitlana Kurinna, Dominik Schwitter, Andrea Marti, Matthias Schäfer, Claus Hellerbrand, Tobias Speicher, Sabine Werner – 6 December 2013 – The nuclear factor erythroid‐derived 2, like 2 (Nrf2) transcription factor is a key regulator of the antioxidant defense system, and pharmacological activation of Nrf2 is a promising strategy for prevention of toxin‐induced liver damage. However, the consequences of Nrf2 activation on liver regeneration (LR) have not been determined.

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