Prothrombotic factors in histologically proven nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

An Verrijken, Sven Francque, Ilse Mertens, Janne Prawitt, Sandrine Caron, Guy Hubens, Eric Marck, Bart Staels, Peter Michielsen, Luc Van Gaal – 23 May 2013 – An independent role of nonalcoholic fatty liver disease (NAFLD) in the development of cardiovascular disease has been suggested, probably mediated through increased levels of prothrombotic factors. Therefore, we examined whether NAFLD is linked to a prothrombotic state, independently of metabolic risk factors in a large single‐center cohort of overweight/obese patients.

Cross‐talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice

Guanhua Xie, Gamze Karaca, Marzena Swiderska‐Syn, Gregory A. Michelotti, Leandi Krüger, Yuping Chen, Richard T. Premont, Steve S. Choi, Anna Mae Diehl – 23 May 2013 – Liver repair involves phenotypic changes in hepatic stellate cells (HSCs) and reactivation of morphogenic signaling pathways that modulate epithelial‐to‐mesenchymal/mesenchymal‐to‐epithelial transitions, such as Notch and Hedgehog (Hh). Hh stimulates HSCs to become myofibroblasts (MFs).

Diastolic dysfunction is a predictor of poor outcomes in patients with cirrhosis, portal hypertension, and a normal creatinine

Luís Ruíz‐del‐Árbol, Linette Achécar, Regina Serradilla, Miguel Á. Rodríguez‐Gandía, Miguel Rivero, Elena Garrido, José J. Natcher – 23 May 2013 – We investigated left ventricular diastolic dysfunction (LVDD) and its relationship with circulatory function and prognosis in cirrhosis with portal hypertension and normal creatinine. Conventional and tissue Doppler (TDI) echocardiography, systemic and hepatic hemodynamics, and the activity of endogenous vasoactive systems (AEVS) were measured prospectively in 80 patients.

Human ezrin‐moesin‐radixin proteins modulate hepatitis C virus infection

Terence N. Bukong, Karen Kodys, Gyongyi Szabo – 23 May 2013 – Host cytoskeletal proteins of the ezrin‐moesin‐radixin (EMR) family have been shown to modulate single‐stranded RNA virus infection through regulating stable microtubule formation. Antibody engagement of CD81, a key receptor for hepatitis C virus (HCV) entry, induces ezrin phosphorylation. Here we tested the role of EMR proteins in regulating HCV infection and explored potential therapeutic targets.

Association of IL28B genotype with fibrosis progression and clinical outcomes in patients with chronic hepatitis C: A longitudinal analysis

Mazen Noureddin, Elizabeth C. Wright, Harvey J. Alter, Shauna Clark, Emmanuel Thomas, Richard Chen, Xiongce Zhao, Cathy Conry‐Cantilena, David E. Kleiner, T. Jake Liang, Marc G. Ghany – 23 May 2013 – Interleukin (IL)28B polymorphisms are associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to therapy. Whether IL28B genotype affects fibrosis progression or clinical outcome is unclear. Our aim was to study the relationship between IL28B genotype and both histological and clinical outcomes in patients with chronic hepatitis C (CHC).

Evaluating progression of liver disease from repeat liver biopsies in children with chronic hepatitis C: A retrospective study

Parvathi Mohan, Bruce A. Barton, Michael R. Narkewicz, Jean P. Molleston, Regino P. Gonzalez‐Peralta, Philip Rosenthal, Karen F. Murray, Barbara Haber, Kathleen B. Schwarz, Zachary D. Goodman – 23 May 2013 – Clinical and histologic progression of liver disease in untreated children with chronic hepatitis C virus (HCV) infection is poorly documented. The aim of this retrospective study was to characterize changes in liver histology over time in a cohort of HCV‐infected children who had more than one liver biopsy separated by over 1 year.

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