Nontransfusional approach to increased platelet count in patients with cirrhosis and thrombocytopenia
Armando Tripodi, Massimo Primignani – 23 May 2013
Evaluating progression of liver disease from repeat liver biopsies in children with chronic hepatitis C: A retrospective study
Parvathi Mohan, Bruce A. Barton, Michael R. Narkewicz, Jean P. Molleston, Regino P. Gonzalez‐Peralta, Philip Rosenthal, Karen F. Murray, Barbara Haber, Kathleen B. Schwarz, Zachary D. Goodman – 23 May 2013 – Clinical and histologic progression of liver disease in untreated children with chronic hepatitis C virus (HCV) infection is poorly documented. The aim of this retrospective study was to characterize changes in liver histology over time in a cohort of HCV‐infected children who had more than one liver biopsy separated by over 1 year.
Liver stiffness after meal intake at different stages of fibrotic evolution
Ingmar Mederacke, Matthias J. Bahr – 23 May 2013
Terutroban, a TP‐receptor antagonist, reduces portal pressure in cirrhotic rats
Eugenio Rosado, Aina Rodríguez‐Vilarrupla, Jorge Gracia‐Sancho, Dinesh Tripathi, Héctor García‐Calderó, Jaume Bosch, Juan Carlos García‐Pagán – 23 May 2013 – Increased production of vasoconstrictive prostanoids, such as thromboxane A2 (TXA2), contributes to endothelial dysfunction and increased hepatic vascular tone in cirrhosis. TXA2 induces vasoconstriction by way of activation of the thromboxane‐A2/prostaglandin‐endoperoxide (TP) receptor.
Extrahepatic Anomalies in Infants With Biliary Atresia: Results of a Large Prospective North American Multicenter Study
Kathleen B. Schwarz, Barbara H. Haber, Philip Rosenthal, Cara L. Mack, Jeffrey Moore, Kevin Bove, Jorge A. Bezerra, Saul J. Karpen, Nanda Kerkar, Benjamin L. Shneider, Yumirle P. Turmelle, Peter F. Whitington, Jean P. Molleston, Karen F. Murray, Vicky L. Ng, René Romero, Kasper S. Wang, Ronald J. Sokol, John C. Magee, Childhood Liver Disease Research and Education Network – 23 May 2013 – The etiology of biliary atresia (BA) is unknown.
Epigenetic regulation of MicroRNA‐122 by peroxisome proliferator activated receptor‐gamma and hepatitis b virus X protein in hepatocellular carcinoma cells
Kyoungsub Song, Chang Han, Jinqiang Zhang, Dongdong Lu, Srikanta Dash, Mark Feitelson, Kyu Lim, Tong Wu – 23 May 2013 – MicroRNA‐122 (miR‐122), a pivotal liver‐specific miRNA, has been implicated in several liver diseases including hepatocellular carcinoma (HCC) and hepatitis C and B viral infection. This study aimed to explore epigenetic regulation of miR‐122 in human HCC cells and to examine the effect of hepatitis C virus (HCV) and hepatitis B virus (HBV).
Impact of sustained virologic response on all‐cause mortality
Lisa I. Backus, Pamela S. Belperio – 23 May 2013
Activator protein 1 transcription factor fos‐related antigen 1 (fra‐1) is dispensable for murine liver fibrosis, but modulates xenobiotic metabolism
Sebastian C. Hasenfuss, Latifa Bakiri, Martin K. Thomsen, Rainer Hamacher, Erwin F. Wagner – 23 May 2013 – The Activator Protein 1 (AP‐1) transcription factor subunit Fos‐related antigen 1 (Fra‐1) has been implicated in liver fibrosis. Here we used loss‐of‐function as well as switchable, cell type‐specific, gain‐of‐function alleles for Fra‐1 to investigate the relevance of Fra‐1 expression in cholestatic liver injury and fibrosis. Our results indicate that Fra‐1 is dispensable in three well‐established, complementary models of liver fibrosis.
Chronic hepatitis B infection: A global disease requiring global strategies
George N. Ioannou – 23 May 2013
Cross‐talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice
Guanhua Xie, Gamze Karaca, Marzena Swiderska‐Syn, Gregory A. Michelotti, Leandi Krüger, Yuping Chen, Richard T. Premont, Steve S. Choi, Anna Mae Diehl – 23 May 2013 – Liver repair involves phenotypic changes in hepatic stellate cells (HSCs) and reactivation of morphogenic signaling pathways that modulate epithelial‐to‐mesenchymal/mesenchymal‐to‐epithelial transitions, such as Notch and Hedgehog (Hh). Hh stimulates HSCs to become myofibroblasts (MFs).