Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF‐α‐converting enzyme activity in mice
Joy X. Jiang, Xiangling Chen, Hiroo Fukada, Nobuko Serizawa, Sridevi Devaraj, Natalie J. Török – 22 May 2013 – Advanced glycation endproducts (AGEs) accumulate in patients with diabetes, yet the link between AGEs and inflammatory and fibrogenic activity in nonalcoholic steatohepatitis (NASH) has not been explored. Tumor necrosis factor alpha (TNF‐α)‐converting enzyme (TACE) is at the center of inflammatory processes.