Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF‐α‐converting enzyme activity in mice

Joy X. Jiang, Xiangling Chen, Hiroo Fukada, Nobuko Serizawa, Sridevi Devaraj, Natalie J. Török – 22 May 2013 – Advanced glycation endproducts (AGEs) accumulate in patients with diabetes, yet the link between AGEs and inflammatory and fibrogenic activity in nonalcoholic steatohepatitis (NASH) has not been explored. Tumor necrosis factor alpha (TNF‐α)‐converting enzyme (TACE) is at the center of inflammatory processes.

Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients

Harald Farnik, Jörg Bojunga, Annemarie Berger, Regina Allwinn, Oliver Waidmann, Bernd Kronenberger, Oliver T. Keppler, Stefan Zeuzem, Christoph Sarrazin, Christian M. Lange – 22 May 2013 – Vitamin D is an important immune modulator that plays an emerging role in inflammatory and metabolic liver diseases, including infection with hepatitis C virus (HCV). In contrast, the relationship between vitamin D metabolism and chronic hepatitis B (CHB) is less well characterized.

Circulating chemokine (C‐X‐C Motif) receptor 5+CD4+ T cells benefit hepatitis B e antigen seroconversion through IL‐21 in patients with chronic hepatitis B virus infection

Yongyin Li, Shiwu Ma, Libo Tang, Yun Li, Wei Wang, Xuan Huang, Qintao Lai, Mingxia Zhang, Jian Sun, Chris Kafai Li, William G.H. Abbott, Nikolai V. Naoumov, Yu Zhang, Jinlin Hou – 22 May 2013 – Given the clinical significance of hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B virus (HBV) infection, it is critical to elucidate the mechanisms regulating this process.

Decreasing Incidence of Symptomatic Epstein‐Barr Virus Disease and Posttransplant Lymphoproliferative Disorder in Pediatric Liver Transplant Recipients: Report of the Studies of Pediatric Liver Transplantation Experience

Michael R. Narkewicz, Michael Green, Stephen Dunn, Michael Millis, Susan McDiarmid, George Mazariegos, Ravinder Anand, Wanrong Yin, Studies of Pediatric Liver Transplantation Research Group – 21 May 2013 – Posttransplant lymphoproliferative disorder (PTLD) causes significant morbidity and mortality in pediatric recipients of liver transplantation (LT). Objective: Describe the incidence of PTLD and symptomatic Epstein‐Barr virus (SEBV) disease in a large multicenter cohort of children who underwent LT with a focus on the risk factors and changes in incidence over time.

Selection and outcomes of living donors with a remnant volume less than 30% after right hepatectomy

Seong Hoon Kim, Young Kyu Kim, Seung Duk Lee, Sang‐Jae Park – 21 May 2013 – The evidence for defining a safe minimal remnant volume after living donor hepatectomy is insufficient. The aim of this study was to evaluate the outcomes of living donors with a remnant/total volume ratio (RTVR) < 30% after right hepatectomy according to the following selection criteria: the preservation of the middle hepatic vein (MHV), an age < 50 years, and no or mild fatty changes in healthy adults.

Respiratory risk score for the prediction of 3‐month mortality and prolonged ventilation after liver transplantation

Moritz Kleine, Florian W. R. Vondran, Kai Johanning, Kai Timrott, Hüseyin Bektas, Frank Lehner, Juergen Klempnauer, Harald Schrem – 21 May 2013 – Survival of critically ill patients is significantly affected by prolonged ventilation. The goal of this study was the development of a respiratory risk score (RRS) for the prediction of 3‐month mortality and prolonged ventilation after liver transplantation (LT). Two hundred fifty‐four consecutive LT patients from a single center were retrospectively randomized into a training group for model design and a validation group.

Deceased Donor Liver Transplantation in Infants and Small Children: Are Partial Grafts Riskier Than Whole Organs?

Ryan P. Cauley, Khashayar Vakili, Kristina Potanos, Nora Fullington, Dionne A. Graham, Jonathan A. Finkelstein, Heung Bae Kim – 21 May 2013 – Infants have the highest wait‐list mortality of all liver transplant candidates. Although previous studies have demonstrated that young children may be at increased risk when they receive partial grafts from adult and adolescent deceased donors (DDs), with few size‐matched organs available, these grafts have increasingly been used to expand the pediatric donor pool.

Subscribe to