Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials

Mazen Noureddin, Jessica Lam, Michael R. Peterson, Michael Middleton, Gavin Hamilton, Thuy‐Anh Le, Ricki Bettencourt, Chris Changchien, David A. Brenner, Claude Sirlin, Rohit Loomba – 20 May 2013 – The magnetic resonance imaging–estimated proton density fat fraction (MRI‐PDFF) is a novel imaging‐based biomarker that allows fat mapping of the entire liver, whereas the magnetic resonance spectroscopy–measured proton density fat fraction (MRS‐PDFF) provides a biochemical measure of liver fat in small regions of interest.

Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice

Delphine Firrincieli, Silvia Zúñiga, Colette Rey, Dominique Wendum, Elisabeth Lasnier, Dominique Rainteau, Thomas Braescu, Thomas Falguières, Mathieu Boissan, Axelle Cadoret, Chantal Housset, Nicolas Chignard – 20 May 2013 – Alterations in apical junctional complexes (AJCs) have been reported in genetic or acquired biliary diseases. The vitamin D nuclear receptor (VDR), predominantly expressed in biliary epithelial cells in the liver, has been shown to regulate AJCs.

Therapeutic advantage of anti‐VAP‐1 over anti‐α4 integrin antibody in concanavalin a‐induced hepatitis

Woo‐Yong Lee, Marko Salmi, Margaret M. Kelly, Sirpa Jalkanen, Paul Kubes – 17 May 2013 – Hepatitis induced by concanavalin A (Con A) in mice is well known to be a T‐lymphocyte‐mediated injury. It has been reported that T helper (Th)1 and Th2 lymphocytes use α4 integrin and vascular adhesion protein (VAP)−1, respectively, to adhere within the hepatic sinusoids. Therefore, we investigated whether inhibition of these molecules ameliorates or worsens the Con A‐induced hepatic injury in vivo.

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