Lipocalin‐2 negatively modulates the epithelial‐to‐mesenchymal transition in hepatocellular carcinoma through the epidermal growth factor (TGF‐beta1)/Lcn2/Twist1 pathway

Yun‐Peng Wang, Goung‐Ran Yu, Mi‐Jin Lee, Sang‐Yeop Lee, In‐Sun Chu, Sun‐Hee Leem, Dae‐Ghon Kim – 20 May 2013 – Lipocalin‐2 (Lcn2) is preferentially expressed in hepatocellular carcinoma (HCC). However, the functional role of Lcn2 in HCC progression is still poorly understood, particularly with respect to its involvement in invasion and metastasis. The purpose of this study was to investigate whether Lcn2 is associated with the epithelial‐mesenchymal transition (EMT) in HCC and to elucidate the underlying signaling pathway(s).

Donor risk index for African American liver transplant recipients with hepatitis C virus

Nathan J. Shores, Jennifer L. Dodge, Sandy Feng, Norah A. Terrault – 20 May 2013 – African American (AA) liver transplant (LT) recipients with hepatitis C virus (HCV) have higher rates of graft loss than other racial/ethnic groups. The Donor Risk Index (DRI) predicts graft loss but is neither race‐ nor disease‐specific and may not be optimal for assessing donor risk for AA HCV‐positive LT recipients. We developed a DRI for AA with HCV with the goal of enhancing graft loss predictions. All U.S.

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