Posttranscriptional destabilization of the liver‐specific long noncoding RNA HULC by the IGF2 mRNA‐binding protein 1 (IGF2BP1)

Monika Hämmerle, Tony Gutschner, Hannah Uckelmann, Sevim Ozgur, Evgenij Fiskin, Matthias Gross, Britta Skawran, Robert Geffers, Thomas Longerich, Kai Breuhahn, Peter Schirmacher, Georg Stoecklin, Sven Diederichs – 31 May 2013 – Selected long noncoding RNAs (lncRNAs) have been shown to play important roles in carcinogenesis. Although the cellular functions of these transcripts can be diverse, many lncRNAs regulate gene expression. In contrast, factors that control the expression of lncRNAs remain largely unknown.

Microsatellite polymorphism in the heme oxygenase‐1 gene promoter is not associated with alcoholic liver disease severity

Anne Lemaire, Eric Trépo, Romy Ouziel, Thierry Gustot, Christophe Moreno, Delphine Degré, Charlotte Minsart, Eric Quertinmont, Vincent Vercruysse, Virginie Wilde, Olivier Moine, Jacques Devière, Marc Abramowicz, Alain Moine, Arnaud Lemmers – 31 May 2013

Sublethal heat treatment promotes epithelial‐mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma

Shuhei Yoshida, Miroslaw Kornek, Naoki Ikenaga, Moritz Schmelzle, Ryota Masuzaki, Eva Csizmadia, Yan Wu, Simon C. Robson, Detlef Schuppan – 31 May 2013 – Radiofrequency ablation (RFA) is a potentially curative therapy for hepatocellular carcinoma (HCC). However, incomplete RFA can induce accelerated invasive growth at the periphery. The mechanisms underlying the RFA‐induced tumor promotion remain largely unexplored. Three human HCC cell lines were exposed to 45°C‐55°C for 10 minutes, simulating the marginal zone of RFA treatment.

Relative adrenal insufficiency in decompensated cirrhosis: Relationship to short‐term risk of severe sepsis, hepatorenal syndrome, and death

Juan Acevedo, Javier Fernández, Verónica Prado, Anibal Silva, Miriam Castro, Marco Pavesi, Daria Roca, Wladimiro Jimenez, Pere Ginès, Vicente Arroyo – 31 May 2013 – The prevalence of relative adrenal insufficiency (RAI) in critically ill cirrhosis patients with severe sepsis is over 60% and associated features include poor liver function, renal failure, refractory shock, and high mortality. RAI may also develop in noncritically ill cirrhosis patients but its relationship to the clinical course has not yet been assessed.

Relative adrenal insufficiency in decompensated cirrhosis: Relationship to short‐term risk of severe sepsis, hepatorenal syndrome, and death

Juan Acevedo, Javier Fernández, Verónica Prado, Anibal Silva, Miriam Castro, Marco Pavesi, Daria Roca, Wladimiro Jimenez, Pere Ginès, Vicente Arroyo – 31 May 2013 – The prevalence of relative adrenal insufficiency (RAI) in critically ill cirrhosis patients with severe sepsis is over 60% and associated features include poor liver function, renal failure, refractory shock, and high mortality. RAI may also develop in noncritically ill cirrhosis patients but its relationship to the clinical course has not yet been assessed.

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