Echocardiography for the detection of portopulmonary hypertension in liver transplant candidates: An analysis of cutoff values

Sarah Raevens, Isabelle Colle, Koen Reyntjens, Anja Geerts, Frederik Berrevoet, Xavier Rogiers, Roberto I. Troisi, Hans Vlierberghe, Michel Pauw – 13 April 2013 – Portopulmonary hypertension (POPH), a complication of chronic liver disease, may be a contraindication to liver transplantation (LT) because of the elevated risk of peritransplant and posttransplant morbidity and mortality. Because POPH is frequently asymptomatic, screening with echocardiography is recommended. The only reliable technique, however, for diagnosing POPH is right heart catheterization (RHC).

Long‐term follow‐up of endoscopic therapy for stenosis of the biliobiliary anastomosis associated with orthotopic liver transplantation

Jörg G. Albert, Natalie Filmann, Julia Elsner, Christian Moench, Jörg Trojan, Jörg Bojunga, Christoph Sarrazin, Mireen Friedrich‐Rust, Eva Herrmann, Wolf Otto Bechstein, Stefan Zeuzem, Wolf Peter Hofmann – 13 April 2013 – Endoscopic treatment for stenosis of an anastomotic biliary stricture (ABS) after orthotopic liver transplantation (OLT) has been proven to be effective and safe, but the long‐term outcomes and the risk factors for recurrence are unknown. All 374 patients who underwent OLT at Frankfurt University Hospital were screened for the occurrence of ABSs.

Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis

Janosch Katt, Dorothee Schwinge, Tanja Schoknecht, Alexander Quaas, Ingo Sobottka, Eike Burandt, Christoph Becker, Markus F. Neurath, Ansgar W. Lohse, Johannes Herkel, Christoph Schramm – 8 April 2013 – T helper (Th)17 cells are important for host defense against bacteria and fungi, but are also involved in the pathogenesis of autoimmune diseases. In primary sclerosing cholangitis (PSC), bile fluid is frequently colonized with pathogens and its strong association with inflammatory bowel disease suggests the contribution of pathogen responses to disease pathogenesis.

α‐fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C

Yasuhiro Asahina, Kaoru Tsuchiya, Takashi Nishimura, Masaru Muraoka, Yuichiro Suzuki, Nobuharu Tamaki, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Mina Nakagawa, Sei Kakinuma, Mamoru Watanabe, Namiki Izumi – 8 April 2013 – The effects of interferon (IFN) treatment and the post‐IFN treatment α‐fetoprotein (AFP) levels on risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C (CHC) are unknown.

Patatin‐like phospholipase domain‐containing 3 I148M affects liver steatosis in patients with chronic hepatitis B

Mauro Viganò, Luca Valenti, Pietro Lampertico, Floriana Facchetti, Benedetta Maria Motta, Roberta D'Ambrosio, Solange Romagnoli, Paola Dongiovanni, Benedetta Donati, Silvia Fargion, Massimo Colombo – 8 April 2013 – Steatosis is a common histopathological feature of chronic hepatitis B (CHB) and has been associated with severity of liver disease.

Characterization of european ancestry nonalcoholic fatty liver disease‐associated variants in individuals of african and hispanic descent

Nicholette D. Palmer, Solomon K. Musani, Laura M. Yerges‐Armstrong, Mary F. Feitosa, Lawrence F. Bielak, Ruben Hernaez, Bratati Kahali, J. Jeffrey Carr, Tamara B. Harris, Min A. Jhun, Sharon L.R. Kardia, Carl D. Langefeld, Thomas H. Mosley, Jill M. Norris, Albert V. Smith, Herman A. Taylor, Lynne E. Wagenknecht, Jiankang Liu, Ingrid B. Borecki, Patricia A. Peyser, Elizabeth K.

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