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Roongruedee Chaiteerakij, William S. Harmsen, Euijung Ryu, Rosebud O. Roberts, Janet E. Olson, Terry M. Therneau, Lewis R. Roberts – 8 April 2013

Intrahepatic cholestasis of pregnancy and associated hepatobiliary disease: A population‐based cohort study

Hanns‐Ulrich Marschall, Elisabeth Wikström Shemer, Jonas F. Ludvigsson, Olof Stephansson – 8 April 2013 – Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease in pregnancy. We aimed to estimate the risk of developing hepatobiliary disease in women with ICP and the odds of developing ICP in women with prevalent hepatobiliary disease. We analyzed data of women with births between 1973 and 2009 and registered in the Swedish Medical Birth Register.

IL‐25 prevents and cures fulminant hepatitis in mice through a myeloid‐derived suppressor cell‐dependent mechanism

Massimiliano Sarra, Maria Laura Cupi, Roberta Bernardini, Giulia Ronchetti, Ivan Monteleone, Marco Ranalli, Eleonora Franzè, Angelamaria Rizzo, Alfredo Colantoni, Flavio Caprioli, Marco Maggioni, Alessandra Gambacurta, Maurizio Mattei, Thomas T. Macdonald, Francesco Pallone, Giovanni Monteleone – 8 April 2013 – Fulminant hepatitis (FH) is a disease characterized by massive destruction of hepatocytes with severe impairment of liver function.

Characterization of european ancestry nonalcoholic fatty liver disease‐associated variants in individuals of african and hispanic descent

Nicholette D. Palmer, Solomon K. Musani, Laura M. Yerges‐Armstrong, Mary F. Feitosa, Lawrence F. Bielak, Ruben Hernaez, Bratati Kahali, J. Jeffrey Carr, Tamara B. Harris, Min A. Jhun, Sharon L.R. Kardia, Carl D. Langefeld, Thomas H. Mosley, Jill M. Norris, Albert V. Smith, Herman A. Taylor, Lynne E. Wagenknecht, Jiankang Liu, Ingrid B. Borecki, Patricia A. Peyser, Elizabeth K.

Patatin‐like phospholipase domain‐containing 3 I148M affects liver steatosis in patients with chronic hepatitis B

Mauro Viganò, Luca Valenti, Pietro Lampertico, Floriana Facchetti, Benedetta Maria Motta, Roberta D'Ambrosio, Solange Romagnoli, Paola Dongiovanni, Benedetta Donati, Silvia Fargion, Massimo Colombo – 8 April 2013 – Steatosis is a common histopathological feature of chronic hepatitis B (CHB) and has been associated with severity of liver disease.

α‐fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C

Yasuhiro Asahina, Kaoru Tsuchiya, Takashi Nishimura, Masaru Muraoka, Yuichiro Suzuki, Nobuharu Tamaki, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Mina Nakagawa, Sei Kakinuma, Mamoru Watanabe, Namiki Izumi – 8 April 2013 – The effects of interferon (IFN) treatment and the post‐IFN treatment α‐fetoprotein (AFP) levels on risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C (CHC) are unknown.

Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis

Janosch Katt, Dorothee Schwinge, Tanja Schoknecht, Alexander Quaas, Ingo Sobottka, Eike Burandt, Christoph Becker, Markus F. Neurath, Ansgar W. Lohse, Johannes Herkel, Christoph Schramm – 8 April 2013 – T helper (Th)17 cells are important for host defense against bacteria and fungi, but are also involved in the pathogenesis of autoimmune diseases. In primary sclerosing cholangitis (PSC), bile fluid is frequently colonized with pathogens and its strong association with inflammatory bowel disease suggests the contribution of pathogen responses to disease pathogenesis.

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