Haofeng Ji, Yu Zhang, Yuanxing Liu, Xiu‐Da Shen, Feng Gao, Terry T. Nguyen, Ronald W. Busuttil, James A. Waschek, Jerzy W. Kupiec‐Weglinski – 7 June 2013 – Hepatic ischemia/reperfusion injury (IRI), an exogenous, antigen‐independent, local inflammation response, occurs in multiple clinical settings, including liver transplantation, hepatic resection, trauma, and shock. The nervous system maintains extensive crosstalk with the immune system through neuropeptide and peptide hormone networks.

Maristela Pinheiro Freire, Isabel C. V. Soares Oshiro, Patricia Rodrigues Bonazzi, Thais Guimarães, Estela Regina Ramos Figueira, Telésforo Bacchella, Silvia Figueiredo Costa, Luiz Augusto Carneiro D'Albuquerque, Edson Abdala – 7 June 2013 – In recipients of liver transplantation (LT), surgical site infection (SSIs) are among the most common types of infection occurring in the first 60 days after LT. In 2007, the Model for End‐Stage Liver Disease (MELD) scoring system was adopted as the basis for prioritizing organ allocation.

Silvia E. Perez-Protto, Cristiano Quintini, Luke F. Reynolds, Jing You, Jacek B. Cywinski, Daniel I. Sessler, Charles Miller – 7 June 2013 – Obesity is among the great health problems facing Americans today. More than 32% of the US population is considered obese on the basis of a body mass index (BMI) exceeding 30 kg/m2. Obesity increases the risk for numerous perioperative complications, but how obesity affects the outcome of liver transplantation remains unclear.

Sara Montagnese, Cristiano De Pittà, Michele De Rui, Michela Corrias, Matteo Turco, Carlo Merkel, Piero Amodio, Rodolfo Costa, Debra J. Skene, Angelo Gatta – 6 June 2013 – A considerable proportion of patients with cirrhosis exhibit insomnia, delayed sleep habits, and excessive daytime sleepiness. These have been variously attributed to hepatic encephalopathy and impaired hepatic melatonin metabolism, but the understanding of their pathophysiology remains limited and their treatment problematic. Sleep is regulated by the interaction of a homeostatic and a circadian process.

Ayse L. Mindikoglu, Thomas C. Dowling, Matthew R. Weir, Stephen L. Seliger, Robert H. Christenson, Laurence S. Magder – 6 June 2013 – Conventional creatinine‐based glomerular filtration rate (GFR) equations are insufficiently accurate for estimating GFR in cirrhosis. The Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) recently proposed an equation to estimate GFR in subjects without cirrhosis using both serum creatinine and cystatin C levels.

Jie Xia, Yongjie Zhou, Hongjie Ji, Yujia Wang, Qiong Wu, Ji Bao, Feng Ye, Yujun Shi, Hong Bu – 6 June 2013 – Histone deacetylases 1 and 2 (HDAC1 and HDAC2) are ubiquitously expressed in tissues, including the liver, and play critical roles in numerous physiopathological processes. Little is known regarding the role of HDAC1 and HDAC2 in liver regeneration.

Anna L. McNaughton, Emma C. Thomson, Kate Templeton, Rory N. Gunson, E. Carol McWilliam Leitch – 6 June 2013

Abhijeet Waghray, Robert O'Shea, Rish Pai, K.V. Narayanan Menon – 6 June 2013

AnnMarie Liapakis, Joseph K. Lim – 6 June 2013

Anup Ramachandran, Mitchell R. McGill, Yuchao Xie, Hong‐Min Ni, Wen‐Xing Ding, Hartmut Jaeschke – 6 June 2013 – Acetaminophen (APAP) overdose is a major cause of hepatotoxicity and acute liver failure in the U.S., but the pathophysiology is incompletely understood. Despite evidence for apoptotic signaling, hepatic cell death after APAP is generally considered necrotic in mice and in humans. Recent findings suggest that the receptor interacting protein kinase 3 (RIP3) acts as a switch from apoptosis to necrosis (programmed necrosis).