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Elisabetta Bacchi, Carlo Negri, Giovanni Targher, Massimo Lanza, Federico Schena, Paolo Moghetti – 20 May 2013

Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials

Mazen Noureddin, Jessica Lam, Michael R. Peterson, Michael Middleton, Gavin Hamilton, Thuy‐Anh Le, Ricki Bettencourt, Chris Changchien, David A. Brenner, Claude Sirlin, Rohit Loomba – 20 May 2013 – The magnetic resonance imaging–estimated proton density fat fraction (MRI‐PDFF) is a novel imaging‐based biomarker that allows fat mapping of the entire liver, whereas the magnetic resonance spectroscopy–measured proton density fat fraction (MRS‐PDFF) provides a biochemical measure of liver fat in small regions of interest.

Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials

Mazen Noureddin, Jessica Lam, Michael R. Peterson, Michael Middleton, Gavin Hamilton, Thuy‐Anh Le, Ricki Bettencourt, Chris Changchien, David A. Brenner, Claude Sirlin, Rohit Loomba – 20 May 2013 – The magnetic resonance imaging–estimated proton density fat fraction (MRI‐PDFF) is a novel imaging‐based biomarker that allows fat mapping of the entire liver, whereas the magnetic resonance spectroscopy–measured proton density fat fraction (MRS‐PDFF) provides a biochemical measure of liver fat in small regions of interest.

Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice

Delphine Firrincieli, Silvia Zúñiga, Colette Rey, Dominique Wendum, Elisabeth Lasnier, Dominique Rainteau, Thomas Braescu, Thomas Falguières, Mathieu Boissan, Axelle Cadoret, Chantal Housset, Nicolas Chignard – 20 May 2013 – Alterations in apical junctional complexes (AJCs) have been reported in genetic or acquired biliary diseases. The vitamin D nuclear receptor (VDR), predominantly expressed in biliary epithelial cells in the liver, has been shown to regulate AJCs.

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