Christian D. Fingas, Joachim C. Mertens, Nataliya Razumilava, Svenja Sydor, Steven F. Bronk, John D. Christensen, Sumera H. Rizvi, Ali Canbay, Jürgen W. Treckmann, Andreas Paul, Alphonse E. Sirica, Gregory J. Gores – 22 May 2013 – Cholangiocarcinoma (CCA) cells paradoxically express the death ligand tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and thus rely on potent survival signals to circumvent cell death by TRAIL. Hedgehog (Hh) signaling is an important survival pathway in CCA.

Frank DiPaola, Pranavkumar Shivakumar, Janet Pfister, Stephanie Walters, Gregg Sabla, Jorge A. Bezerra – 22 May 2013 – Peribiliary glands (PBGs) are clusters of epithelial cells residing in the submucosal compartment of extrahepatic bile ducts (EHBDs). Though their function is largely undefined, they may represent a stem cell niche. Here, we hypothesized that PBGs are populated by mature and undifferentiated cells capable of proliferation in pathological states.

Vincent P.E.G. Pruniau, Els Louagie, Bas Brouwers, Jeroen Declercq, John W.M. Creemers – 22 May 2013

John W. Schoggins – 22 May 2013

Michael Vouche, Laura Kulik, Rohi Atassi, Khairuddin Memon, Ryan Hickey, Daniel Ganger, Frank H. Miller, Vahid Yaghmai, Michael Abecassis, Talia Baker, Mary Mulcahy, Ritu Nayar, Robert J. Lewandowski, Riad Salem – 22 May 2013 – The aim of this study was to compare radiological and pathological changes and test the adjunct efficacy of Sorafenib to Y90 as a bridge to transplantation in hepatocellular carcinoma (HCC). 15 patients with 16 HCC lesions were randomized to Y90 without (Group A, n = 9) or with Sorafenib (Group B, n = 7).

Erin M. McCartney, Karla J. Helbig, Sumudu K. Narayana, Nicholas S. Eyre, Amanda L. Aloia, Michael R. Beard – 22 May 2013 – Host factors play an important role in all facets of the hepatitis C virus (HCV) life cycle and one such host factor is signal transducer and activator of transcription 3 (STAT3). The HCV core protein has been shown to directly interact with and activate STAT3, while oxidative stress generated during HCV replication in a replicon‐based model also induced STAT3 activation. However, despite these findings the precise role of STAT3 in the HCV life cycle remains unknown.

Amy K. Kim, James Dziura, Mario Strazzabosco – 22 May 2013

René L. Jacobs, Jelske N. Veen, Dennis E. Vance – 22 May 2013

Takeo Toshima, Mitsuo Shimada, Toru Ikegami, Toru Utsunomiya, Tetsuya Ikemoto, Yuji Morine, Tomoharu Yoshizumi, Yuji Soejima, Ken Shirabe, Yoshihiko Maehara – 21 May 2013

Surakit Pungpapong, Bashar A. Aqel, Ludi Koning, Jennifer L. Murphy, Tanisha M. Henry, Kristen L. Ryland, Maria L. Yataco, Raj Satyanarayana, Barry G. Rosser, Hugo E. Vargas, Michael R. Charlton, Andrew P. Keaveny – 21 May 2013 – The safety, efficacy, and effect on immunosuppression levels of telaprevir (TVR) or boceprevir (BOC) in combination with peginterferon (PEG‐IFN) and ribavirin (RBV) in recipients of liver transplantation (LT) with hepatitis C virus (HCV) genotype 1 have not been defined.