Anticoagulation in cirrhosis: Ready … set … wait!
Susana Seijo, Juan Carlos Garcia‐Pagan – 23 May 2013
Retracted: Equilibrative nucleoside transporter (ENT)‐1‐dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion
Michael A. Zimmerman, Eunyoung Tak, Stefan F. Ehrentraut, Maria Kaplan, Antasia Giebler, Tingting Weng, Doo‐Sup Choi, Michael R. Blackburn, Igal Kam, Holger K. Eltzschig, Almut Grenz – 23 May 2013 – Ischemia and reperfusion‐elicited tissue injury contributes to morbidity and mortality of hepatic surgery and during liver transplantation. Previous studies implicated extracellular adenosine signaling in liver protection.
Finding the balance: The role of S‐adenosylmethionine and phosphatidylcholine metabolism in development of nonalcoholic fatty liver disease
René L. Jacobs, Jelske N. Veen, Dennis E. Vance – 22 May 2013
Nonsteroidal anti‐inflammatory drug use, chronic liver disease, and hepatocellular carcinoma: The egg of columbus or another illusion?
Amy K. Kim, James Dziura, Mario Strazzabosco – 22 May 2013
Signal transducer and activator of transcription 3 is a proviral host factor for hepatitis C virus
Erin M. McCartney, Karla J. Helbig, Sumudu K. Narayana, Nicholas S. Eyre, Amanda L. Aloia, Michael R. Beard – 22 May 2013 – Host factors play an important role in all facets of the hepatitis C virus (HCV) life cycle and one such host factor is signal transducer and activator of transcription 3 (STAT3). The HCV core protein has been shown to directly interact with and activate STAT3, while oxidative stress generated during HCV replication in a replicon‐based model also induced STAT3 activation. However, despite these findings the precise role of STAT3 in the HCV life cycle remains unknown.
Radiological‐pathological analysis of WHO, RECIST, EASL, mRECIST and DWI: Imaging analysis from a prospective randomized trial of Y90 ± sorafenib
Michael Vouche, Laura Kulik, Rohi Atassi, Khairuddin Memon, Ryan Hickey, Daniel Ganger, Frank H. Miller, Vahid Yaghmai, Michael Abecassis, Talia Baker, Mary Mulcahy, Ritu Nayar, Robert J. Lewandowski, Riad Salem – 22 May 2013 – The aim of this study was to compare radiological and pathological changes and test the adjunct efficacy of Sorafenib to Y90 as a bridge to transplantation in hepatocellular carcinoma (HCC). 15 patients with 16 HCC lesions were randomized to Y90 without (Group A, n = 9) or with Sorafenib (Group B, n = 7).
Regulating interferon antiviral activity: A role for epidermal growth factor receptor
John W. Schoggins – 22 May 2013
The AlfpCre mouse revisited: Evidence for liver steatosis related to growth hormone deficiency
Vincent P.E.G. Pruniau, Els Louagie, Bas Brouwers, Jeroen Declercq, John W.M. Creemers – 22 May 2013
Identification of intramural epithelial networks linked to peribiliary glands that express progenitor cell markers and proliferate after injury in mice
Frank DiPaola, Pranavkumar Shivakumar, Janet Pfister, Stephanie Walters, Gregg Sabla, Jorge A. Bezerra – 22 May 2013 – Peribiliary glands (PBGs) are clusters of epithelial cells residing in the submucosal compartment of extrahepatic bile ducts (EHBDs). Though their function is largely undefined, they may represent a stem cell niche. Here, we hypothesized that PBGs are populated by mature and undifferentiated cells capable of proliferation in pathological states.
Polo‐like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma
Christian D. Fingas, Joachim C. Mertens, Nataliya Razumilava, Svenja Sydor, Steven F. Bronk, John D. Christensen, Sumera H. Rizvi, Ali Canbay, Jürgen W. Treckmann, Andreas Paul, Alphonse E. Sirica, Gregory J. Gores – 22 May 2013 – Cholangiocarcinoma (CCA) cells paradoxically express the death ligand tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) and thus rely on potent survival signals to circumvent cell death by TRAIL. Hedgehog (Hh) signaling is an important survival pathway in CCA.