Loss of caspase‐8 in hepatocytes accelerates the onset of liver regeneration in mice through premature nuclear factor kappa B activation

Julia Freimuth, Jörg‐Martin Bangen, Daniela Lambertz, Wei Hu, Yulia Alexandrowna Nevzorova, Roland Sonntag, Nikolaus Gassler, Dieter Riethmacher, Christian Trautwein, Christian Liedtke – 31 May 2013 – The cytokine tumor necrosis factor alpha (TNF‐α; TNF) plays a critical role early in liver regeneration following partial hepatectomy (PH). TNF stimulates at least three different pathways leading to nuclear factor kappa B (NF‐κB) activation, apoptosis signaling by way of caspase‐8 (Casp8), and activation of cJun N‐terminal kinases (JNK).

Peritransplant absolute lymphocyte count as a predictive factor for advanced recurrence of hepatitis C after liver transplantation

Shunji Nagai, Atsushi Yoshida, Keisuke Kohno, David Altshuler, Mio Nakamura, Kimberly A. Brown, Marwan S. Abouljoud, Dilip Moonka – 31 May 2013 – Lymphocytes play an active role in natural immunity against hepatitis C virus (HCV). We hypothesized that a lower absolute lymphocyte count (ALC) may alter HCV outcome after liver transplantation (LT). The aim of this study was to investigate the impact of peritransplant ALC on HCV recurrence following LT. A total of 289 LT patients between 2005 and 2011 were evaluated.

Peritransplant absolute lymphocyte count as a predictive factor for advanced recurrence of hepatitis C after liver transplantation

Shunji Nagai, Atsushi Yoshida, Keisuke Kohno, David Altshuler, Mio Nakamura, Kimberly A. Brown, Marwan S. Abouljoud, Dilip Moonka – 31 May 2013 – Lymphocytes play an active role in natural immunity against hepatitis C virus (HCV). We hypothesized that a lower absolute lymphocyte count (ALC) may alter HCV outcome after liver transplantation (LT). The aim of this study was to investigate the impact of peritransplant ALC on HCV recurrence following LT. A total of 289 LT patients between 2005 and 2011 were evaluated.

Relative adrenal insufficiency in decompensated cirrhosis: Relationship to short‐term risk of severe sepsis, hepatorenal syndrome, and death

Juan Acevedo, Javier Fernández, Verónica Prado, Anibal Silva, Miriam Castro, Marco Pavesi, Daria Roca, Wladimiro Jimenez, Pere Ginès, Vicente Arroyo – 31 May 2013 – The prevalence of relative adrenal insufficiency (RAI) in critically ill cirrhosis patients with severe sepsis is over 60% and associated features include poor liver function, renal failure, refractory shock, and high mortality. RAI may also develop in noncritically ill cirrhosis patients but its relationship to the clinical course has not yet been assessed.

Relative adrenal insufficiency in decompensated cirrhosis: Relationship to short‐term risk of severe sepsis, hepatorenal syndrome, and death

Juan Acevedo, Javier Fernández, Verónica Prado, Anibal Silva, Miriam Castro, Marco Pavesi, Daria Roca, Wladimiro Jimenez, Pere Ginès, Vicente Arroyo – 31 May 2013 – The prevalence of relative adrenal insufficiency (RAI) in critically ill cirrhosis patients with severe sepsis is over 60% and associated features include poor liver function, renal failure, refractory shock, and high mortality. RAI may also develop in noncritically ill cirrhosis patients but its relationship to the clinical course has not yet been assessed.

Sublethal heat treatment promotes epithelial‐mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma

Shuhei Yoshida, Miroslaw Kornek, Naoki Ikenaga, Moritz Schmelzle, Ryota Masuzaki, Eva Csizmadia, Yan Wu, Simon C. Robson, Detlef Schuppan – 31 May 2013 – Radiofrequency ablation (RFA) is a potentially curative therapy for hepatocellular carcinoma (HCC). However, incomplete RFA can induce accelerated invasive growth at the periphery. The mechanisms underlying the RFA‐induced tumor promotion remain largely unexplored. Three human HCC cell lines were exposed to 45°C‐55°C for 10 minutes, simulating the marginal zone of RFA treatment.

Microsatellite polymorphism in the heme oxygenase‐1 gene promoter is not associated with alcoholic liver disease severity

Anne Lemaire, Eric Trépo, Romy Ouziel, Thierry Gustot, Christophe Moreno, Delphine Degré, Charlotte Minsart, Eric Quertinmont, Vincent Vercruysse, Virginie Wilde, Olivier Moine, Jacques Devière, Marc Abramowicz, Alain Moine, Arnaud Lemmers – 31 May 2013

Subscribe to