Liver transplantation normalizes serum hepcidin level and cures iron metabolism alterations in HFE hemochromatosis

Edouard Bardou‐Jacquet, Julie Philip, Richard Lorho, Martine Ropert, Marianne Latournerie, Pauline Houssel‐Debry, Dominique Guyader, Olivier Loréal, Karim Boudjema, Pierre Brissot – 14 June 2013 – Defects in human hemochromatosis protein (HFE) cause iron overload due to reduced hepatic hepcidin secretion. Liver transplantation (LT) is a key treatment for potential complications from HFE‐related hereditary hemochromatosis (HH). This study evaluated hepcidin secretion and iron burden after LT to elucidate HH pathophysiology.

Vasoactive intestinal peptide attenuates liver ischemia/reperfusion injury in mice via the cyclic adenosine monophosphate–protein kinase a pathway

Haofeng Ji, Yu Zhang, Yuanxing Liu, Xiu‐Da Shen, Feng Gao, Terry T. Nguyen, Ronald W. Busuttil, James A. Waschek, Jerzy W. Kupiec‐Weglinski – 7 June 2013 – Hepatic ischemia/reperfusion injury (IRI), an exogenous, antigen‐independent, local inflammation response, occurs in multiple clinical settings, including liver transplantation, hepatic resection, trauma, and shock. The nervous system maintains extensive crosstalk with the immune system through neuropeptide and peptide hormone networks.

Surgical site infections in liver transplant recipients in the model for end‐stage liver disease era: An analysis of the epidemiology, risk factors, and outcomes

Maristela Pinheiro Freire, Isabel C. V. Soares Oshiro, Patricia Rodrigues Bonazzi, Thais Guimarães, Estela Regina Ramos Figueira, Telésforo Bacchella, Silvia Figueiredo Costa, Luiz Augusto Carneiro D'Albuquerque, Edson Abdala – 7 June 2013 – In recipients of liver transplantation (LT), surgical site infection (SSIs) are among the most common types of infection occurring in the first 60 days after LT. In 2007, the Model for End‐Stage Liver Disease (MELD) scoring system was adopted as the basis for prioritizing organ allocation.

Comparable graft and patient survival in lean and obese liver transplant recipients

Silvia E. Perez-Protto, Cristiano Quintini, Luke F. Reynolds, Jing You, Jacek B. Cywinski, Daniel I. Sessler, Charles Miller – 7 June 2013 – Obesity is among the great health problems facing Americans today. More than 32% of the US population is considered obese on the basis of a body mass index (BMI) exceeding 30 kg/m2. Obesity increases the risk for numerous perioperative complications, but how obesity affects the outcome of liver transplantation remains unclear.

Sleep‐wake abnormalities in patients with cirrhosis

Sara Montagnese, Cristiano De Pittà, Michele De Rui, Michela Corrias, Matteo Turco, Carlo Merkel, Piero Amodio, Rodolfo Costa, Debra J. Skene, Angelo Gatta – 6 June 2013 – A considerable proportion of patients with cirrhosis exhibit insomnia, delayed sleep habits, and excessive daytime sleepiness. These have been variously attributed to hepatic encephalopathy and impaired hepatic melatonin metabolism, but the understanding of their pathophysiology remains limited and their treatment problematic. Sleep is regulated by the interaction of a homeostatic and a circadian process.

Performance of chronic kidney disease epidemiology collaboration creatinine‐cystatin C equation for estimating kidney function in cirrhosis

Ayse L. Mindikoglu, Thomas C. Dowling, Matthew R. Weir, Stephen L. Seliger, Robert H. Christenson, Laurence S. Magder – 6 June 2013 – Conventional creatinine‐based glomerular filtration rate (GFR) equations are insufficiently accurate for estimating GFR in cirrhosis. The Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) recently proposed an equation to estimate GFR in subjects without cirrhosis using both serum creatinine and cystatin C levels.

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