Study of hepatitis B virus quasispecies by ultra‐deep pyrosequencing: Resolving the nitty‐gritty
Francisco‐Rodriguez Frias, David Tabernero, Rafael Esteban, Maria Buti – 1 August 2013
Kinetic differences in the induction of interferon stimulated genes by interferon‐α and interleukin 28B are altered by infection with hepatitis C virus
Nikolaus Jilg, Wenyu Lin, Jian Hong, Esperance A. Schaefer, David Wolski, James Meixong, Kaku Goto, Cynthia Brisac, Pattranuch Chusri, Dahlene N. Fusco, Stephane Chevaliez, Jay Luther, Kattareeya Kumthip, Thomas J. Urban, Lee F. Peng, Georg M. Lauer, Raymond T. Chung – 1 August 2013 – Several genome‐wide association studies (GWAS) have identified a genetic polymorphism associated with the gene locus for interleukin 28B (IL28B), a type III interferon (IFN), as a major predictor of clinical outcome in hepatitis C.
Nanoparticles encapsulating hepatitis B virus cytosine‐phosphate‐guanosine induce therapeutic immunity against HBV infection
Shujuan Lv, Jun Wang, Shuang Dou, Xianzhu Yang, Xiang Ni, Rui Sun, Zhigang Tian, Haiming Wei – 1 August 2013 – Infection with hepatitis B virus (HBV) is the most common cause of liver disease worldwide. However, because the current interferon (IFN)‐based treatments have toxic side effects and marginal efficacy, improved antivirals are essential.
Relating serum GGT to ALT activity enhances its predictability on treatment outcome in chronic hepatitis C
Ahmad Amanzada, Giuliano Ramadori, Sabine Mihm – 1 August 2013
Prognostic impact of telomere maintenance gene polymorphisms on hepatocellular carcinoma patients with chronic hepatitis B
Seok Won Jung, Neung Hwa Park, Jung Woo Shin, Bo Ryung Park, Chang Jae Kim, Jong‐Eun Lee, Eun‐Soon Shin, Jeong A Kim, Young‐Hwa Chung – 1 August 2013 – Our goal was to determine whether single‐nucleotide polymorphisms (SNPs) of telomere maintenance genes influence the development and clinical outcomes of patients with hepatitis B virus (HBV)‐associated hepatocellular carcinoma (HCC). We evaluated 20 SNPs of five telomere maintenance genes in 702 patients with HCC and 351 hepatitis B virus surface antigen‐positive controls without HCC.
Hepcidin as a predictor of treatment response in chronic hepatitis C infection
Pavel Strnad, Renwar Nuraldeen, Janett Fischer, Thomas Berg, Christian Trautwein – 1 August 2013
Reply
James E. Everhart, Elizabeth Wright – 1 August 2013
Use of noninvasive markers of portal hypertension and timing of screening endoscopy for gastroesophageal varices in patients with chronic liver disease
Annalisa Berzigotti, Jaime Bosch, Thomas D. Boyer – 1 August 2013
Use of noninvasive markers of portal hypertension and timing of screening endoscopy for gastroesophageal varices in patients with chronic liver disease
Annalisa Berzigotti, Jaime Bosch, Thomas D. Boyer – 1 August 2013
Autophagy suppresses tumorigenesis of hepatitis B virus‐associated hepatocellular carcinoma through degradation of microRNA‐224
Sheng‐Hui Lan, Shan‐Ying Wu, Roberto Zuchini, Xi‐Zhang Lin, Ih‐Jen Su, Ting‐Fen Tsai, Yen‐Ju Lin, Cheng‐Tao Wu, Hsiao‐Sheng Liu – 1 August 2013 – In hepatocellular carcinoma (HCC), dysregulated expression of microRNA‐224 (miR‐224) and impaired autophagy have been reported separately. However, the relationship between them has not been explored. In this study we determined that autophagy is down‐regulated and inversely correlated with miR‐224 expression in hepatitis B virus (HBV)‐associated HCC patient specimens. These results were confirmed in liver tumors of HBV X gene transgenic mice.