Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients

Luca Quagliata, Matthias S. Matter, Salvatore Piscuoglio, Leila Arabi, Christian Ruiz, Alfredo Procino, Michal Kovac, Francesca Moretti, Zuzanna Makowska, Tujana Boldanova, Jesper B. Andersen, Monika Hämmerle, Luigi Tornillo, Markus H. Heim, Sven Diederichs, Clemente Cillo, Luigi M. Terracciano – 20 September 2013 – Hepatocellular carcinoma (HCC) is among the leading causes of cancer‐related death. Despite the advances in diagnosis and management of HCC, the biology of this tumor remains poorly understood.

Incidence and long‐term risk of de novo malignancies after liver transplantation with implications for prevention and detection

Harald Schrem, Marlene Kurok, Alexander Kaltenborn, Arndt Vogel, Ulla Walter, Lea Zachau, Michael P. Manns, Jürgen Klempnauer, Moritz Kleine – 14 September 2013 – The goal of this study was the characterization of long‐term cancer risks after liver transplantation (LT) with implications for prevention and detection.

Outcomes for recipients of liver transplantation for alpha‐1‐antitrypsin deficiency–related cirrhosis

Elizabeth J. Carey, Vivek N. Iyer, Darlene R. Nelson, Justin H. Nguyen, Michael J. Krowka – 10 September 2013 – Alpha‐1‐antitrypsin (AAT) deficiency is a rare genetic disease caused by an abnormal production of the serine protease inhibitor AAT. Liver transplantation (LT) cures cirrhosis caused by AAT deficiency and restores the normal production of AAT. There are few reports on the post‐LT outcomes of patients with AAT deficiency. The aim of this study was to determine the characteristics and outcomes of patients undergoing LT for AAT deficiency at 3 large transplant centers.

Incidence of colorectal cancer after liver transplantation for primary sclerosing cholangitis: A systematic review and meta‐analysis

Siddharth Singh, Jithinraj Edakkanambeth Varayil, Edward V. Loftus, Jayant A. Talwalkar – 10 September 2013 – Patients with primary sclerosing cholangitis (PSC) and associated inflammatory bowel disease (IBD) have an increased risk of colorectal cancer (CRC). We estimated the pooled incidence of CRC after liver transplantation (LT) in patients with PSC as well as in a subset of patients with associated IBD (PSC‐IBD). Through a systematic review of major bibliographic databases up to April 1, 2013, we identified cohort studies reporting the incidence of de novo CRC after LT for PSC.

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