Reply
Markus Peck‐Radosavljevic, Wolfgang Sieghart, Florian Hucke, for the Vienna HCC Study Group – 1 October 2013
Substance abuse treatment and its association with relapse to alcohol use after liver transplantation
James R. Rodrigue, Douglas W. Hanto, Michael P. Curry – 1 October 2013 – Many liver transplantation (LT) programs require substance abuse (SA) treatment for candidates with a history of alcohol abuse. However, there are no data indicating that SA treatment prevents post‐LT alcohol relapse. We examined 118 adults who underwent LT from May 2002 to February 2011 to explore the relationship between SA treatment and post‐LT relapse to any alcohol use. Sixty‐one patients (52%) with a history of alcohol abuse or dependence received SA treatment before LT.
Drinking coffee burns hepatic fat by inducing lipophagy coupled with mitochondrial β‐oxidation
Wen‐Xing Ding – 1 October 2013
Liver regeneration by stem/progenitor cells
Tohru Itoh, Atsushi Miyajima – 1 October 2013 – The liver is renowned for its strong, robust regenerative capacity, employing different modes of regeneration according to type and extent of injury. The process of compensatory hypertrophy of the liver upon partial hepatectomy has been standing as a classical model for studying organ regeneration in mammals and a subject of exhaustive analyses. Meanwhile, in view of the physiological relevance for many of the human liver pathologies induced upon toxic insults or hepatitis, other injury models have recently drawn increasing attention.
Macrophage plasticity and polarization in liver homeostasis and pathology
Antonio Sica, Pietro Invernizzi, Alberto Mantovani – 1 October 2013 – Resident and recruited macrophages are key players in the homeostatic function of the liver and in its response to tissue damage. In response to environmental signals, macrophages undergo polarized activation to M1 or M2 or M2‐like activation states. These are extremes of a spectrum in a universe of activation states. Progress has been made in understanding the molecular mechanisms underlying the polarized activation of mononuclear phagocytes.
Improving the quality of clinical practice guidelines for clinicians and patients
Ian A. Rowe, Richard Parker, Matthew J. Armstrong, Andrew L. King, Diarmaid D. Houlihan, David J. Mutimer – 1 October 2013
Role of retinol binding protein 4 in hepatic steatosis
Tetsuji Fujita – 1 October 2013
Assessment for retreatment (ART) score for repeated transarterial chemoembolization in patients with hepatocellular carcinoma
Masatoshi Kudo, Tadaaki Arizumi, Kazuomi Ueshima – 1 October 2013
Role of immunosuppression in post–endoscopic retrograde cholangiopancreatography pancreatitis after liver transplantation: A retrospective analysis
Ryan Law, Carlos Leal, Barham Abu Dayyeh, Michael D. Leise, Domingo Balderramo, Todd H. Baron, Andres Cardenas – 1 October 2013 – Endoscopic retrograde cholangiopancreatography (ERCP) is frequently used for diagnosis and therapeutic interventions in recipients of liver transplantation (LT) who develop biliary complications. Post–endoscopic retrograde cholangiopancreatography acute pancreatitis (PEP) is the most common major adverse event after ERCP; however, the frequency of PEP in LT recipients is not well established.
Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH
Salvatore Sutti, Aastha Jindal, Irene Locatelli, Marco Vacchiano, Luca Gigliotti, Cristina Bozzola, Emanuele Albano – 1 October 2013 – Previous studies have shown that human nonalcoholic steatohepatitis (NASH) is often associated with the presence of circulating antibodies against protein adducted by lipid peroxidation products. Here we used the methionine‐choline deficient (MCD) model of NASH to characterize the possible involvement of adaptive immunity in NASH.