Glomerular filtration rate equations for liver‐kidney transplantation in patients with cirrhosis: Validation of current recommendations

Claire Francoz, Mitra K. Nadim, Aurore Baron, Dominique Prié, Corinne Antoine, Jacques Belghiti, Dominique Valla, Richard Moreau, François Durand – 26 August 2013 – Simultaneous liver and kidney transplantation (SLKT) remains the procedure of choice for patients with both endstage liver disease and kidney failure. Stringent guidelines are needed to avoid unnecessary kidney transplantation. A recent consensus meeting proposed criteria based on the Modified Diet in Renal Disease (MDRD)‐6 equation to estimate glomerular filtration rate (GFR).

Evaluation of abdominal ultrasonography mass screening for hepatocellular carcinoma in Taiwan

Yen‐Po Yeh, Tsung‐Hui Hu, Po‐Yuan Cho, Hsiu‐Hsi Chen, Amy Ming‐Fang Yen, Sam Li‐Sheng Chen, Sherry Yueh‐Hsia Chiu, Jean Ching‐Yuan Fann, Wei‐Wen Su, Yi‐Jen Fang, Shih‐Tien Chen, Hsiao‐Ching San, Hung‐Pin Chen, Chao‐Sheng Liao, Changhua Community‐Based Abdominal Ultrasonography Screening Group – 26 August 2013 – Mass screening with abdominal ultrasonography (AUS) has been suggested as a tool to control adult hepatocellular carcinoma (HCC) in individuals, but its efficacy in reducing HCC mortality has never been demonstrated.

Indocyanine green retention test as a noninvasive marker of portal hypertension and esophageal varices in compensated liver cirrhosis

Andrea Lisotti, Francesco Azzaroli, Federica Buonfiglioli, Marco Montagnani, Paolo Cecinato, Laura Turco, Claudio Calvanese, Patrizia Simoni, Massimo Guardigli, Rosario Arena, Alessandro Cucchetti, Antonio Colecchia, Davide Festi, Rita Golfieri, Giuseppe Mazzella – 26 August 2013 – Noninvasive markers would be useful for the assessment of portal hypertension (PH) and esophageal varices (EV) in patients with cirrhosis.

CD8 T cells primed in the gut‐associated lymphoid tissue induce immune‐mediated cholangitis in mice

Daniel Seidel, Ira Eickmeier, Anja A. Kühl, Alf Hamann, Christoph Loddenkemper, Eckart Schott – 26 August 2013 – The pathogenesis of primary sclerosing cholangitis (PSC) remains poorly understood. Since PSC predominantly occurs in patients with inflammatory bowel disease, autoimmunity triggered by activated T cells migrating from the gut to the liver is a possible mechanism. We hypothesized that T cells primed in the gut‐associated lymphoid tissue (GALT) by a specific antigen migrate to the liver and cause cholangitis when they recognize the same antigen on cholangiocytes.

Gankyrin promotes tumor growth and metastasis through activation of IL‐6/STAT3 signaling in human cholangiocarcinoma

Tongsen Zheng, Xuehui Hong, Jiabei Wang, Tiemin Pei, Yingjian Liang, Dalong Yin, Ruipeng Song, Xuan Song, Zhaoyang Lu, Shuyi Qi, Jiaren Liu, Boshi Sun, Changming Xie, Shangha Pan, Yuejin Li, Xiaohe Luo, Shuai Li, Xiang Fang, Nishant Bhatta, Hongchi Jiang, Lianxin Liu – 26 August 2013 – Although gankyrin is involved in the tumorigenicity and metastasis of some malignancies, the role of gankyrin in cholangiocarcinoma (CCA) is unclear. In this study we investigated the expression of gankyrin in human CCA tissues and cell lines.

Cardiac arrest during adult liver transplantation: A single institution's experience with 1238 deceased donor transplants

Takashi Matsusaki, Ibtesam A. Hilmi, Raymond M. Planinsic, Abhinav Humar, Tetsuro Sakai – 20 August 2013 – Liver transplantation (LT) is one of the highest risk noncardiac surgeries. We reviewed the incidence, etiologies, and outcomes of intraoperative cardiac arrest (ICA) during LT. Adult cadaveric LT recipients from January 1, 2001 through December 31, 2009 were reviewed. ICA was defined as an event requiring either closed chest compression or open cardiac massage. Cardiac arrest patients who recovered with only pharmacological interventions were excluded.

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