Prevalence and natural history of histologically proven chronic liver disease in a longitudinal cohort of patients with type 1 diabetes

David J. Harman, Philip V. Kaye, Rebecca Harris, Ayako Suzuki, Anastasios Gazis, Guruprasad P. Aithal – 28 February 2014 – Although a higher prevalence of raised liver enzymes and altered echotexture on ultrasound have been reported in patients with type 1 diabetes mellitus (T1DM), the histological spectrum and natural history of chronic liver disease (CLD) in T1DM is unknown. We investigated the prevalence and outcome of histologically proven CLD in a longitudinal cohort of patients with T1DM.

Treatment of phenylketonuria using minicircle‐based naked‐DNA gene transfer to murine liver

Hiu Man Viecelli, Richard P. Harbottle, Suet Ping Wong, Andrea Schlegel, Marinee K. Chuah, Thierry VandenDriessche, Cary O. Harding, Beat Thöny – 28 February 2014 – Host immune response to viral vectors, persistence of nonintegrating vectors, and sustained transgene expression are among the major challenges in gene therapy. To overcome these hurdles, we successfully used minicircle (MC) naked‐DNA vectors devoid of any viral or bacterial sequences for the long‐term treatment of murine phenylketonuria, a model for a genetic liver defect.

Effect of the pretransplant serum sodium concentration on outcomes following liver transplantation

Michael D. Leise, Byung Cheol Yun, Joseph J. Larson, Joanne T. Benson, Ju Dong Yang, Terry M. Therneau, Charles B. Rosen, Julie K. Heimbach, Scott W. Biggins, W. Ray Kim – 25 February 2014 – Hyponatremia is associated with an increased risk of mortality on the liver transplantation (LT) waiting list. Although the incorporation of the serum sodium (Na) level into the Model for End‐Stage Liver Disease score may reduce wait‐list mortality, concerns remain about a potential association between pre‐LT hyponatremia and decreased post‐LT survival.

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