Fiona McPhee, Dennis Hernandez, Fei Yu, Joseph Ueland, Aaron Monikowski, Arlene Carifa, Paul Falk, Chunfu Wang, Robert Fridell, Timothy Eley, Nannan Zhou, David Gardiner – 15 March 2013 – In a sentinel cohort, hepatitis C virus (HCV) patients (primarily genotype [GT] 1a) were treated with daclatasvir (NS5A inhibitor) and asunaprevir (NS3 protease inhibitor). Preexistence, emergence, and persistence of resistance variants in patients who failed this treatment are described.

Jin‐Hua Sun, Min Gao, Susan Roberts, Robert Fridell – 15 March 2013

Massimiliano Cadamuro, Giorgia Nardo, Stefano Indraccolo, Luigi Dall'Olmo, Luisa Sambado, Lidia Moserle, Irene Franceschet, Michele Colledan, Marco Massani, Tommaso Stecca, Nicolò Bassi, Stuart Morton, Carlo Spirli, Romina Fiorotto, Luca Fabris, Mario Strazzabosco – 15 March 2013 – Cholangiocarcinoma (CCA) is characterized by an abundant stromal reaction. Cancer‐associated fibroblasts (CAFs) are pivotal in tumor growth and invasiveness and represent a potential therapeutic target.

Miriam B. Vos – 15 March 2013

Mukund Venu, Eric Martin, Kia Saeian, Samer Gawrieh – 14 March 2013 – Deficiencies in vitamins A, D, and E have been linked to night blindness, bone health, and post–liver transplant reperfusion injury. The aim of this study was to determine the prevalence and predictive factors of fat‐soluble vitamin deficiencies in liver transplant candidates. We reviewed the medical records of liver transplant candidates at our center from January 2008 to September 2011.

Delphine Degre, Isabelle Colle, Hans Vlierberghe, Christophe Moreno – 14 March 2013

M. Kyle Jensen, Kathleen M. Campbell, Maria H. Alonso, Jaimie D. Nathan, Frederick C. Ryckman, Greg M. Tiao – 11 March 2013 – Portal vein thrombosis (PVT) occurs in ≤12% of pediatric recipients of liver transplantation (LT). Known complications of PVT include portal hypertension, allograft loss, and mortality. The management of PVT is varied. A single‐center, case‐control study of pediatric LT recipients with portal vein (PV) changes after LT was performed.

Jie Ding, Shenglin Huang, Ying Wang, Qi Tian, Ruopeng Zha, Haibing Shi, Qifeng Wang, Chao Ge, Taoyang Chen, Yingjun Zhao, Linhui Liang, Jinjun Li, Xianghuo He – 11 March 2013 – Nuclear factor kappa B (NF‐κB) is an important factor linking inflammation and tumorigenesis. In this study we experimentally demonstrated through a high‐throughput luciferase reporter screen that NF‐κB signaling can be directly targeted by nearly 29 microRNAs (miRNAs). Many of these miRNAs can directly target NF‐κB signaling nodes by binding to their 3′ untranslated region (UTR).

Dan Xu, Fu Yang, Ji‐hang Yuan, Ling Zhang, Hai‐shan Bi, Chuan‐chuan Zhou, Feng Liu, Fang Wang, Shu‐han Sun – 11 March 2013 – In recent years, long noncoding RNAs (lncRNAs) have been investigated as a new class of regulators of biological function. A recent study reported that lncRNAs control cell proliferation in hepatocellular carcinoma (HCC). However, the role of lncRNAs in liver regeneration and the overall mechanisms remain largely unknown.

Michael A. Zimmerman, Talia Baker, Nathan P. Goodrich, Chris Freise, Johnny C. Hong, Sean Kumer, Peter Abt, Adrian H. Cotterell, Benjamin Samstein, James E. Everhart, Robert M. Merion – 11 March 2013 – Adult recipients of living donor liver transplantation (LDLT) have a higher incidence of biliary complications than recipients of deceased donor liver transplantation (DDLT). Our objective was to define the intensity of the interventions and the time to resolution after the diagnosis of biliary complications after liver transplantation.