Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice

Xin‐An Wang, Ran Zhang, Dingsheng Jiang, Wei Deng, Shumin Zhang, Shan Deng, Jinfeng Zhong, Tao Wang, Li‐Hua Zhu, Li Yang, Shufen Hong, Sen Guo, Ke Chen, Xiao‐Fei Zhang, Zhigang She, Yingjie Chen, Qinglin Yang, Xiao‐Dong Zhang, Hongliang Li – 7 March 2013 – Obesity is a calorie‐excessive state associated with high risk of diabetes, atherosclerosis, and certain types of tumors. Obesity may induce inflammation and insulin resistance (IR).

The nutritional management of hepatic encephalopathy in patients with cirrhosis: International society for hepatic encephalopathy and nitrogen metabolism consensus

Piero Amodio, Chantal Bemeur, Roger Butterworth, Juan Cordoba, Akinobu Kato, Sara Montagnese, Misael Uribe, Hendrik Vilstrup, Marsha Y. Morgan – 7 March 2013 – Nitrogen metabolism plays a major role in the development of hepatic encephalopathy (HE) in patients with cirrhosis. Modulation of this relationship is key to the management of HE, but is not the only nutritional issue that needs to be addressed. The assessment of nutritional status in patients with cirrhosis is problematic.

Impact of primary biliary cirrhosis on perceived quality of life: The UK‐PBC national study

George F. Mells, Greta Pells, Julia L. Newton, Andrew J. Bathgate, Andrew K. Burroughs, Michael A. Heneghan, James M. Neuberger, Darren B. Day, Samantha J. Ducker, Richard N. Sandford, Graeme J. Alexander, David E.J. Jones, UK‐PBC Consortium – 7 March 2013 – Primary biliary cirrhosis (PBC) has a complex clinical phenotype, with debate about the extent and specificity of frequently described systemic symptoms such as fatigue.

Predicting early allograft failure and mortality after liver transplantation: The role of the postoperative model for end‐stage liver disease score

Gebhard Wagener, Brian Raffel, Andrew T. Young, Moury Minhaz, Jean Emond – 6 March 2013 – Early allograft dysfunction (EAD) is a serious complication after liver transplantation (LT). There is no uniform definition of EAD, and most definitions are based on arbitrary laboratory values. The aim of this study was to devise a definition of EAD that maximizes the predictive power for early death and graft failure.

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