Dan Xu, Fu Yang, Ji‐hang Yuan, Ling Zhang, Hai‐shan Bi, Chuan‐chuan Zhou, Feng Liu, Fang Wang, Shu‐han Sun – 11 March 2013 – In recent years, long noncoding RNAs (lncRNAs) have been investigated as a new class of regulators of biological function. A recent study reported that lncRNAs control cell proliferation in hepatocellular carcinoma (HCC). However, the role of lncRNAs in liver regeneration and the overall mechanisms remain largely unknown.

Jie Ding, Shenglin Huang, Ying Wang, Qi Tian, Ruopeng Zha, Haibing Shi, Qifeng Wang, Chao Ge, Taoyang Chen, Yingjun Zhao, Linhui Liang, Jinjun Li, Xianghuo He – 11 March 2013 – Nuclear factor kappa B (NF‐κB) is an important factor linking inflammation and tumorigenesis. In this study we experimentally demonstrated through a high‐throughput luciferase reporter screen that NF‐κB signaling can be directly targeted by nearly 29 microRNAs (miRNAs). Many of these miRNAs can directly target NF‐κB signaling nodes by binding to their 3′ untranslated region (UTR).

M. Kyle Jensen, Kathleen M. Campbell, Maria H. Alonso, Jaimie D. Nathan, Frederick C. Ryckman, Greg M. Tiao – 11 March 2013 – Portal vein thrombosis (PVT) occurs in ≤12% of pediatric recipients of liver transplantation (LT). Known complications of PVT include portal hypertension, allograft loss, and mortality. The management of PVT is varied. A single‐center, case‐control study of pediatric LT recipients with portal vein (PV) changes after LT was performed.

Jérôme Dumortier, Olivier Guillaud, Olivier Boillot – 8 March 2013 – After organ transplantation, strategies for simplifying the therapeutic regimen may improve adherence and prevent acute organ rejection and/or late graft loss. The aim of the present study was to evaluate the safety and efficacy of conversion from a tacrolimus (TAC) twice daily (bid) formulation to a once daily (qd) formulation in a large cohort of adult liver transplantation (LT) patients.

Roniel Cabrera, Gyongyi Szabo – 8 March 2013

Matthias Hardtke‐Wolenski, Katja Fischer, Fatih Noyan, Jerome Schlue, Christine S. Falk, Maike Stahlhut, Norman Woller, Florian Kuehnel, Richard Taubert, Michael P. Manns, Elmar Jaeckel – 8 March 2013 – Autoimmune hepatitis (AIH) is defined as a chronic liver disease with loss of tolerance against liver tissue eventually leading to cirrhosis if left untreated. 80%‐90% of patients can be treated with a life‐long immunosuppression. Unfortunately, there are strong drug‐related side effects and steroid‐refractory patients.

Safi Dokmak, Béatrice Aussilhou, Jacques Belghiti – 8 March 2013

Eun‐Sook Park, Yong Kwang Park, Chan Young Shin, Seung Hwa Park, Sung Hyun Ahn, Doo Hyun Kim, Keo‐Heun Lim, So Young Kwon, Kwang Pyo Kim, Sung‐Il Yang, Baik L. Seong, Kyun‐Hwan Kim – 8 March 2013 – Liver regeneration after liver damage caused by toxins and pathogens is critical for liver homeostasis. Retardation of liver proliferation was reported in hepatitis B virus (HBV) X protein (HBx)‐transgenic mice. However, the underlying mechanism of the HBx‐mediated disturbance of liver regeneration is unknown.

Beverley Kok, Matthew R. Foxton, Christopher Clough, Debbie L. Shawcross – 7 March 2013

Hongping Xia, London Lucien P.J. Ooi, Kam M. Hui – 7 March 2013 – Tumor recurrence and metastases are the major obstacles to improving the prognosis of patients with hepatocellular carcinoma (HCC). To identify novel risk factors associated with HCC recurrence and metastases, we have established a panel of recurrence‐associated microRNAs (miRNAs) by comparing miRNA expression in recurrent and nonrecurrent human HCC tissue samples using microarrays (recurrence is defined as recurrent disease occurring within a 2‐year time point of the original treatment).