Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients

Mazen Noureddin, Katherine P. Yates, Ivana A. Vaughn, Brent A. Neuschwander‐Tetri, Arun J. Sanyal, Arthur McCullough, Raphael Merriman, Bilal Hameed, Edward Doo, David E. Kleiner, Cynthia Behling, Rohit Loomba, for the NASH CRN – 17 May 2013 – The characteristics of nonalcoholic fatty liver disease (NAFLD) in elderly patients are unknown. Therefore, we aimed to examine the differences between elderly and nonelderly patients with NAFLD and to identify determinants of nonalcoholic steatohepatitis (NASH) and advanced fibrosis (bridging fibrosis or cirrhosis) in elderly patients.

Therapeutic advantage of anti‐VAP‐1 over anti‐α4 integrin antibody in concanavalin a‐induced hepatitis

Woo‐Yong Lee, Marko Salmi, Margaret M. Kelly, Sirpa Jalkanen, Paul Kubes – 17 May 2013 – Hepatitis induced by concanavalin A (Con A) in mice is well known to be a T‐lymphocyte‐mediated injury. It has been reported that T helper (Th)1 and Th2 lymphocytes use α4 integrin and vascular adhesion protein (VAP)−1, respectively, to adhere within the hepatic sinusoids. Therefore, we investigated whether inhibition of these molecules ameliorates or worsens the Con A‐induced hepatic injury in vivo.

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