Laura Elisa Buitrago‐Molina, Silke Marhenke, Thomas Longerich, Amar Deep Sharma, Aristeidis E. Boukouris, Robert Geffers, Bruno Guigas, Michael P. Manns, Arndt Vogel – 23 March 2013 – Hepatocellular carcinoma (HCC) frequently arises in the context of chronic injury that promotes DNA damage and chromosomal aberrations. The cyclin‐dependent kinase inhibitor p21 is an important transcriptional target of several tumor suppressors, which promotes cell cycle arrest in response to many stimuli.

Cliff Rowe, Dave T. Gerrard, Roz Jenkins, Andrew Berry, Kesta Durkin, Lars Sundstrom, Chris E. Goldring, B. Kevin Park, Neil R. Kitteringham, Karen Piper Hanley, Neil A. Hanley – 23 March 2013 – Failure to predict hepatotoxic drugs in preclinical testing makes it imperative to develop better liver models with a stable phenotype in culture. Stem cell‐derived models offer promise, with differentiated hepatocyte‐like cells currently considered to be “fetal‐like” in their maturity.

Frederick J. Suchy – 23 March 2013

Jens U. Marquardt, Kerstin Fischer, Katharina Baus, Anubha Kashyap, Shengyun Ma, Markus Krupp, Matthias Linke, Andreas Teufel, Ulrich Zechner, Dennis Strand, Snorri S. Thorgeirsson, Peter R. Galle, Susanne Strand – 23 March 2013 – Sirtuin 6 (SIRT6) is a member of the sirtuin family of NAD+–dependent deacetylases. Genetic deletion of Sirt6 in mice results in a severe degenerative phenotype with impaired liver function and premature death. The role of SIRT6 in development and progression of hepatocellular carcinoma is currently unknown.

Matthew D. Hickey, David J. Quan, Peter V. Chin‐Hong, John P. Roberts – 22 March 2013 – Latent tuberculosis infection is an important problem for solid organ transplant recipients because of the frequency of its occurrence and its potential for reactivation. Because of the high mortality rate associated with active tuberculosis infections in transplant recipients, guidelines from the American Thoracic Society recommend treatment for latent tuberculosis in this population.

Ignacio A. Echenique, Michael G. Ison – 22 March 2013 – Advances in surgical techniques, immunosuppressive medications, and robust infectious disease prophylaxis have resulted in liver transplantation becoming the treatment of choice for patients with end‐stage liver disease and unresectable hepatocellular carcinoma. Nonetheless, organ transplantation is not without risk. Unexpected donor‐derived disease transmission is a newly recognized risk that complicates approximately 0.2% of all organ transplants.

Humberto E. Bohorquez, Ari J. Cohen, Nigel Girgrah, David S. Bruce, Ian C. Carmody, Shoba Joshi, Trevor W. Reichman, George Therapondos, Andrew L. Mason, George E. Loss – 22 March 2013 – The use of livers from hepatitis B surface antigen–negative (HBsAg−)/hepatitis B core antibody–positive (HBcAb+) donors in liver transplantation (LT) for HBsAg−/HBcAb− recipients is still controversial because of a lack of standard antiviral prophylaxis and long‐term follow‐up. We present our 13‐year experience with the use of HBcAb+ donor livers in HBcAb− recipients.

Eytan Mor, Eviatar Nesher, Ziv Ben‐Ari, Irit Weissman, Ezra Shaharabani, Sigal Eizner, Evegny Solomonov, Ruth Rahamimov, Marius Braun – 22 March 2013 – Using living donor organs for sequential liver and kidney transplantation (SeqLKT) in patients with primary hyperoxaluria type 1 (PH1) has emerged as a viable approach. Taking both organs from a single donor, however, is rare. There are 8 reported cases of SeqLKT in the literature, and in all but 1 case, children were the recipients. We present our experience with SeqLKT in 2 young adults with PH1.

Yu‐Shu Cheng, Ping‐Yi Lin, Kuo‐Hua Lin, Chih‐Jan Ko, Chia‐Cheng Lin, Yao‐Li Chen – 22 March 2013

Neta Barashi, Ido D. Weiss, Ori Wald, Hanna Wald, Katia Beider, Michal Abraham, Shiri Klein, Daniel Goldenberg, Jonathan Axelrod, Eli Pikarsky, Rinat Abramovitch, Evelyne Zeira, Eithan Galun, Amnon Peled – 21 March 2013 – Human hepatocellular carcinoma (HCC) is an inflammation‐induced cancer, which is the third‐leading cause of cancer mortality worldwide. We investigated the role of the chemokine receptors, CCR5 and CCR1, in regulating inflammation and tumorigenesis in an inflammation‐induced HCC model in mice.