Jihong Ma, Chunbin Zou, Lida Guo, Danushka S. Seneviratne, Xinping Tan, Yong‐Kook Kwon, Jiyan An, Robert Bowser, Marie C. DeFrances, Reza Zarnegar – 3 October 2013 – Met, the transmembrane tyrosine kinase receptor for hepatocyte growth factor (HGF), is known to function as a potent antiapoptotic mediator in normal and neoplastic cells. Herein we report that the intracellular cytoplasmic tail of Met has evolved to harbor a tandem pair of caspase‐3 cleavage sites, which bait, trap, and disable the active site of caspase‐3, thereby blocking the execution of apoptosis.

Victor I. Machicao, Maya Balakrishnan, Michael B. Fallon – 2 October 2013 – The association of chronic liver disease with respiratory symptoms and hypoxia is well recognized. Over the last century, three pulmonary complications specific to chronic liver disease have been characterized: hepatopulmonary syndrome (HPS), portopulmonary hypertension (POPH), and hepatic hydrothorax (HH). The development of portal hypertension is fundamental in the pathogenesis of each of these disorders.

Isaac T.W. Harley, Traci E. Stankiewicz, Daniel A. Giles, Samir Softic, Leah M. Flick, Monica Cappelletti, Rachel Sheridan, Stavra A. Xanthakos, Kris A. Steinbrecher, R. Balfour Sartor, Rohit Kohli, Christopher L. Karp, Senad Divanovic – 2 October 2013 – Inflammation plays a central pathogenic role in the pernicious metabolic and end‐organ sequelae of obesity. Among these sequelae, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the developed world.

Alphonse E. Sirica, Gregory J. Gores – 2 October 2013

Alphonse E. Sirica, Gregory J. Gores – 2 October 2013

Victor I. Machicao, Maya Balakrishnan, Michael B. Fallon – 2 October 2013 – The association of chronic liver disease with respiratory symptoms and hypoxia is well recognized. Over the last century, three pulmonary complications specific to chronic liver disease have been characterized: hepatopulmonary syndrome (HPS), portopulmonary hypertension (POPH), and hepatic hydrothorax (HH). The development of portal hypertension is fundamental in the pathogenesis of each of these disorders.

Vinitha Jacob, Kirsten C. Sadler – 2 October 2013

Partha Mukhopadhyay, Mohanraj Rajesh, Zongxian Cao, Béla Horváth, Ogyi Park, Hua Wang, Katalin Erdelyi, Eileen Holovac, Yuping Wang, Lucas Liaudet, Nabila Hamdaoui, Fouad Lafdil, György Haskó, Csaba Szabo, A. Hamid Boulares, Bin Gao, Pal Pacher – 2 October 2013 – Poly (ADP‐ribose) polymerase 1 (PARP‐1) is a constitutive enzyme, the major isoform of the PARP family, which is involved in the regulation of DNA repair, cell death, metabolism, and inflammatory responses.

1 October 2013

Donald B. Smith, Jens Bukh, Carla Kuiken, A. Scott Muerhoff, Charles M. Rice, Jack T. Stapleton, Peter Simmonds – 1 October 2013 – The 2005 consensus proposal for the classification of hepatitis C virus (HCV) presented an agreed and uniform nomenclature for HCV variants and the criteria for their assignment into genotypes and subtypes. Since its publication, the available dataset of HCV sequences has vastly expanded through advancement in nucleotide sequencing technologies and an increasing focus on the role of HCV genetic variation in disease and treatment outcomes.