Riad Salem, Vincenzo Mazzaferro, Bruno Sangro – 19 March 2013

Chia‐Yu Wang, Mitchell D. Knutson – 19 March 2013 – Divalent metal‐ion transporter‐1 (DMT1) is required for iron uptake by the intestine and developing erythroid cells. DMT1 is also present in the liver, where it has been implicated in the uptake of transferrin‐bound iron (TBI) and non‐transferrin‐bound iron (NTBI), which appears in the plasma during iron overload. To test the hypothesis that DMT1 is required for hepatic iron uptake, we examined mice with the Dmt1 gene selectively inactivated in hepatocytes (Dmt1liv/liv).

Kai Wang, Ho Yeong Lim, Stephanie Shi, Jeeyun Lee, Shibing Deng, Tao Xie, Zhou Zhu, Yuli Wang, David Pocalyko, Wei Jennifer Yang, Paul A. Rejto, Mao Mao, Cheol‐Keun Park, Jiangchun Xu – 18 March 2013 – Cancer is a genetic disease with frequent somatic DNA alterations. Studying recurrent copy number aberrations (CNAs) in human cancers would enable the elucidation of disease mechanisms and the prioritization of candidate oncogenic drivers with causal roles in oncogenesis.

Johann Guillemot, Nabil G. Seidah – 16 March 2013

Ying Wang, Chang Han, Lu Lu, Susan Magliato, Tong Wu – 16 March 2013 – Hedgehog (Hh) signaling plays an important role in embryonic development and in the regulation of a variety of cellular functions. Aberrant activation of Hh signaling has been implicated in several human cancers including hepatocellular carcinoma (HCC). In this study we examined the pathobiological functions and molecular mechanisms of the Hh signaling pathway in HCC cells.

Ryan M. Kwok, Dawn M. Torres, Stephen A. Harrison – 16 March 2013 – Vitamin D is a secosteroid with known effects on calcium homeostasis that has recently been shown to have other significant functions regarding immune modulation, cell differentiation and proliferation, and the inflammatory response. As our understanding of the many functions of vitamin D has grown, the presence of vitamin D deficiency (VDD) has become more evident in Western populations. Concomitantly, nonalcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease.

Christine Schwienbacher, Alice Serafin, Alessandra Zanon, Peter P. Pramstaller, Irene Pichler, Andrew A. Hicks – 16 March 2013

Elisabetta Bacchi, Carlo Negri, Giovanni Targher, Niccolò Faccioli, Massimo Lanza, Giacomo Zoppini, Elisabetta Zanolin, Federico Schena, Enzo Bonora, Paolo Moghetti – 16 March 2013 – Although lifestyle interventions are considered the first‐line therapy for nonalcoholic fatty liver disease (NAFLD), which is extremely common in people with type 2 diabetes, no intervention studies have compared the effects of aerobic (AER) or resistance (RES) training on hepatic fat content in type 2 diabetic subjects with NAFLD.

Lui Ng, Ronnie Tung‐Ping Poon, Simon Yau, Ariel Chow, Colin Lam, Hung‐Sing Li, Thomas Chung‐Cheung Yau, Wai‐Lun Law, Roberta Pang – 16 March 2013 – Early reports suggested that actopaxin, a member of the focal adhesion proteins, regulates cell migration. Here we investigated whether actopaxin is involved in hepatocellular carcinoma (HCC) progression and metastasis. We examined actopaxin expression in human HCC samples using immunohistochemistry and western blotting.

Maite Martínez‐Uña, Marta Varela‐Rey, Ainara Cano, Larraitz Fernández‐Ares, Naiara Beraza, Igor Aurrekoetxea, Ibon Martínez‐Arranz, Juan L. García‐Rodríguez, Xabier Buqué, Daniela Mestre, Zigmund Luka, Conrad Wagner, Cristina Alonso, Richard H. Finnell, Shelly C. Lu, M. Luz Martínez‐Chantar, Patricia Aspichueta, José M. Mato – 16 March 2013 – Methionine adenosyltransferase 1A (MAT1A) and glycine N‐methyltransferase (GNMT) are the primary genes involved in hepatic S‐adenosylmethionine (SAMe) synthesis and degradation, respectively.