Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer

Jiayi Wang, Lifang Ma, Wenhao Weng, Yongxia Qiao, Yue Zhang, Jiangtu He, Hongmei Wang, Weifan Xiao, Lanlan Li, Qinghua Chu, Qiuhui Pan, Yongchun Yu, Fenyong Sun – 26 March 2013 – Yes‐associated protein (YAP), the downstream effecter of the Hippo‐signaling pathway as well as cyclic adenosine monophosphate response element‐binding protein (CREB), has been linked to hepatocarcinogenesis. However, little is known about whether and how YAP and CREB interact with each other.

Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients

Carlos Benítez, María‐Carlota Londoño, Rosa Miquel, Tommaso‐Maria Manzia, Juan G. Abraldes, Juan‐José Lozano, Marc Martínez‐Llordella, Marta López, Roberta Angelico, Felix Bohne, Pilar Sese, Frederic Daoud, Patrick Larcier, Dave L. Roelen, Frans Claas, Gavin Whitehouse, Jan Lerut, Jacques Pirenne, Antoni Rimola, Giuseppe Tisone, Alberto Sánchez‐Fueyo – 26 March 2013 – Lifelong immunosuppression increases morbidity and mortality in liver transplantation.

The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice

Laura Elisa Buitrago‐Molina, Silke Marhenke, Thomas Longerich, Amar Deep Sharma, Aristeidis E. Boukouris, Robert Geffers, Bruno Guigas, Michael P. Manns, Arndt Vogel – 23 March 2013 – Hepatocellular carcinoma (HCC) frequently arises in the context of chronic injury that promotes DNA damage and chromosomal aberrations. The cyclin‐dependent kinase inhibitor p21 is an important transcriptional target of several tumor suppressors, which promotes cell cycle arrest in response to many stimuli.

Proteome‐wide analyses of human hepatocytes during differentiation and dedifferentiation

Cliff Rowe, Dave T. Gerrard, Roz Jenkins, Andrew Berry, Kesta Durkin, Lars Sundstrom, Chris E. Goldring, B. Kevin Park, Neil R. Kitteringham, Karen Piper Hanley, Neil A. Hanley – 23 March 2013 – Failure to predict hepatotoxic drugs in preclinical testing makes it imperative to develop better liver models with a stable phenotype in culture. Stem cell‐derived models offer promise, with differentiated hepatocyte‐like cells currently considered to be “fetal‐like” in their maturity.

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