Noninvasive assessment of liver fibrosis: The clinical context and question are important
Emmanuel A. Tsochatzis, Giacomo Germani, Amar P. Dhillon, Andrew K. Burroughs – 2 December 2011
Hepatitis C virus induces interferon‐λ and interferon‐stimulated genes in primary liver cultures
Svetlana Marukian, Linda Andrus, Timothy P. Sheahan, Christopher T. Jones, Edgar D. Charles, Alexander Ploss, Charles M. Rice, Lynn B. Dustin – 2 December 2011 – Hepatitis C virus (HCV) replication in primary liver cells is less robust than that in hepatoma cell lines, suggesting that innate antiviral mechanisms in primary cells may limit HCV replication or spread. Here we analyzed the expression of 47 genes associated with interferon (IFN) induction and signaling following HCV infection of primary human fetal liver cell (HFLC) cultures from 18 different donors.
An essential role for monocyte chemoattractant protein‐1 in alcoholic liver injury: Regulation of proinflammatory cytokines and hepatic steatosis in mice
Pranoti Mandrekar, Aditya Ambade, Arlene Lim, Gyongyi Szabo, Donna Catalano – 2 December 2011 – The importance of chemokines in alcoholic liver injury has been implicated. The role of the chemokine, monocyte chemoattractant protein‐1 (MCP‐1), elevated in patients with alcoholic liver disease is not yet understood. Here, we evaluated the pathophysiological significance of MCP‐1 and its receptor, chemokine (C‐C motif) receptor 2 (CCR2), in alcoholic liver injury.
Eyewitnesses to history and participants as well
Keith D. Lindor, M.D. – 2 December 2011
Reply
Yang Liu, Shengdian Wang, Fusheng Wang, Dongling Li, Linghua Zheng, Pan Zheng – 2 December 2011
Idiopathic noncirrhotic intrahepatic portal hypertension is an ongoing problem in India
Ashish Goel, Banumathi Ramakrishna, Kadiyala Madhu, Uday Zachariah, Jeyamani Ramachandran, Shyamkumar N. Keshava, Elwyn Elias, Chundamannil E. Eapen – 2 December 2011
Sequential alterations of microrna expression in hepatocellular carcinoma development and venous metastasis
Chun‐Ming Wong, Carmen Chak‐Lui Wong, Joyce Man‐Fong Lee, Dorothy Ngo‐Yin Fan, Sandy Leung‐Kuen Au, Irene Oi‐Lin Ng – 2 December 2011 – Hepatocellular carcinoma (HCC) is a prevalent cancer with an extremely high mortality rate attributed to HCC metastasis, which is the major cause of tumor recurrence and organ failure. Presence of tumor thrombi in the portal veins (venous metastases) is a clinicopathological feature of metastatic HCCs.
I148M variant of PNPLA3 confer increased risk for nonalcoholic fatty liver disease not only in European population, but also in Chinese population
Xiaohua Li, Qingchuan Zhao, Kaichun Wu, Daiming Fan – 2 December 2011
Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus
Gulam H. Syed, Aleem Siddiqui – 2 December 2011 – Hepatitis C virus (HCV) relies on host lipid metabolic pathways for its replication, assembly, secretion, and entry. HCV induces de novo lipogenesis, inhibits β‐oxidation, and lipoprotein export resulting in a lipid‐enriched cellular environment critical for its proliferation. We investigated the effects of a hypolipidemic agent, nordihydroguaiaretic acid (NDGA), on host lipid/fatty acid synthesis and HCV life cycle. NDGA negated the HCV‐induced alteration of host lipid homeostasis.
Human immunodeficiency virus and liver disease forum 2010: Conference proceedings
Kenneth E. Sherman, David L. Thomas, Raymond T. Chung – 2 December 2011 – Liver disease continues to represent a critical mediator of morbidity and mortality in those with human immunodeficiency virus (HIV) infection. The frequent presence and overlap of concomitant injurious processes, including hepatitis C virus and hepatitis B virus infections, hepatoxicity associated with antiretroviral therapeutic agents, alcohol, and other toxins, in the setting of immunosuppression lead to rapid fibrotic progression and early development of end‐stage liver disease.