Living donor liver transplantation versus deceased donor liver transplantation for hepatocellular carcinoma: A meta‐analysis

Wenhua Liang, Linwei Wu, Xiaoting Ling, Paul M. Schroder, Weiqiang Ju, Dongping Wang, Yushu Shang, Yuan Kong, Zhiyong Guo, Xiaoshun He – 9 June 2012 – Because of the severe organ shortage, living donor liver transplantation (LDLT) offers a timely alternative to deceased donor liver transplantation (DDLT) for patients with hepatocellular carcinoma (HCC). However, the higher recurrence rate of HCC after LDLT and the indication criteria remain controversial.

Targeted delivery of interferon‐α to hepatitis B virus‐infected cells using T‐cell receptor‐like antibodies

Changhua Ji, Konduru S.R. Sastry, Georg Tiefenthaler, Jennifer Cano, Tenny Tang, Zi Zong Ho, Denise Teoh, Sandhya Bohini, Antony Chen, Surya Sankuratri, Paul A. Macary, Patrick Kennedy, Han Ma, Stefan Ries, Klaus Klumpp, Erhard Kopetzki, Antonio Bertoletti – 9 June 2012 – During antiviral therapy, specific delivery of interferon‐α (IFNα) to infected cells may increase its antiviral efficacy, trigger a localized immune reaction, and reduce the side effects caused by systemic administration.

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug‐induced, and inflammatory liver diseases

Shashi Bala, Jan Petrasek, Shiv Mundkur, Donna Catalano, Ivan Levin, Jeanine Ward, Hawau Alao, Karen Kodys, Gyongyi Szabo – 9 June 2012 – MicroRNAs are fine tuners of diverse biological responses and are expressed in various cell types of the liver. Here we hypothesized that circulating microRNAs (miRNAs) may serve as biomarkers of liver damage and inflammation.

Retinol binding protein 4 and retinol in steatotic and nonsteatotic rat livers in the setting of partial hepatectomy under ischemia/reperfusion

Maria Elias‐Miró, Marta Massip‐Salcedo, Jens Raila, Florian Schweigert, Mariana Mendes‐Braz, Fernando Ramalho, Mónica B. Jiménez‐Castro, Araní Casillas‐Ramírez, Raquel Bermudo, Antoni Rimola, Juan Rodes, Carmen Peralta – 9 June 2012 – Steatotic livers show increased hepatic damage and impaired regeneration after partial hepatectomy (PH) under ischemia/reperfusion (I/R), which is commonly applied in clinical practice to reduce bleeding. The known function of retinol‐binding protein 4 (RBP4) is to transport retinol in the circulation.

Background progenitor activation is associated with recurrence after hepatectomy of combined hepatocellular‐cholangiocarcinoma

Xiong Cai, Jian Zhai, David E. Kaplan, Yijun Zhang, Lining Zhou, Xutao Chen, Guangyang Qian, Qiudong Zhao, Yonghai Li, Lu Gao, Wenming Cong, Minghua Zhu, Zhenlin Yan, Lehua Shi, Dong Wu, Lixin Wei, Feng Shen, Mengchao Wu – 9 June 2012 – Hepatic progenitor cells (HPC) play important roles in both liver regeneration and carcinogenesis. Combined hepatocellular‐cholangiocarcinoma (CHC), a malignant primary liver tumor with poor prognosis, is thought to be of HPC origin. However, the prognostic significance of this etiology is not well defined.

Liver‐specific ablation of Krüppel‐associated box–associated protein 1 in mice leads to male‐predominant hepatosteatosis and development of liver adenoma

Karolina Bojkowska, Fabio Aloisio, Marco Cassano, Adamandia Kapopoulou, Francesca Santoni de Sio, Nadine Zangger, Sandra Offner, Cristina Cartoni, Charles Thomas, Simon Quenneville, Kai Johnsson, Didier Trono – 8 June 2012 – The liver is characterized by sexually dimorphic gene expression translating into sex‐specific differences in lipid, drug, steroid hormone, and xenobiotic metabolism, with distinct responses of males and females to environmental challenges.

Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism

Giovanni Musso, Maurizio Cassader, Franco De Michieli, Floriano Rosina, Fabio Orlandi, Roberto Gambino – 8 June 2012 – Nonalcoholic fatty liver disease (NAFLD) ranges from simple steatosis (SS) to nonalcoholic steatohepatitis (NASH). Though liver‐related risk seems confined to NASH, it is currently unclear whether NASH has a higher risk of cardiovascular disease (CVD) and diabetes than SS as a result of the coexistence of obesity and other cardiometabolic confounders. Adipose tissue is an emerging modulator of liver disease in NAFLD and of cardiometabolic disease in the general population.

Etiologies, risk factors, and outcomes of bacterial pneumonia after living donor liver transplantation

Toru Ikegami, Ken Shirabe, Rumi Matono, Tomoharu Yoshizumi, Yuji Soejima, Hideaki Uchiyama, Hiroto Kayashima, Kazutoyo Morita, Yoshihiko Maehara – 4 June 2012 – The prevalence and clinical characteristics of bacterial pneumonia after living donor liver transplantation (LDLT) have not yet been elucidated. We performed a retrospective analysis of 346 LDLT recipients. Fifty patients (14.5%) experienced bacterial pneumonia after LDLT, and they had a higher short‐term mortality rate (42.0%) than patients with other types of bacterial infections after LDLT.

Cognitive performance as a predictor of hepatic encephalopathy in pretransplant patients with cirrhosis receiving psychoactive medications: A prospective study

Jasmohan S. Bajaj, Leroy R. Thacker, Douglas M. Heuman, Richard K. Sterling, R. Todd Stravitz, Arun J. Sanyal, Velimir Luketic, Michael Fuchs, Ho Chong S. Gilles, James B. Wade – 4 June 2012 – Psychiatric disorders and medications may affect the cognitive performance of patients with cirrhosis and complicate the diagnosis and prediction of hepatic encephalopathy (HE).

Subscribe to