Gulam H. Syed, Aleem Siddiqui – 2 December 2011 – Hepatitis C virus (HCV) relies on host lipid metabolic pathways for its replication, assembly, secretion, and entry. HCV induces de novo lipogenesis, inhibits β‐oxidation, and lipoprotein export resulting in a lipid‐enriched cellular environment critical for its proliferation. We investigated the effects of a hypolipidemic agent, nordihydroguaiaretic acid (NDGA), on host lipid/fatty acid synthesis and HCV life cycle. NDGA negated the HCV‐induced alteration of host lipid homeostasis.

Kenneth E. Sherman, David L. Thomas, Raymond T. Chung – 2 December 2011 – Liver disease continues to represent a critical mediator of morbidity and mortality in those with human immunodeficiency virus (HIV) infection. The frequent presence and overlap of concomitant injurious processes, including hepatitis C virus and hepatitis B virus infections, hepatoxicity associated with antiretroviral therapeutic agents, alcohol, and other toxins, in the setting of immunosuppression lead to rapid fibrotic progression and early development of end‐stage liver disease.

Kathryn J. Fowler, Jeffrey J. Brown, Vamsi R. Narra – 2 December 2011 – This article is a review of magnetic resonance imaging (MRI) of incidental focal liver lesions. This review provides an overview of liver MRI protocol, diffusion‐weighted imaging, and contrast agents. Additionally, the most commonly encountered benign and malignant lesions are discussed with emphasis on imaging appearance and the diagnostic performance of MRI based on a review of the literature. (HEPATOLOGY 2011)

Angelo Sangiovanni, Massimo Colombo – 2 December 2011

Liming Sheng, Yongjie Shui – 2 December 2011

Vincenzo Cardinale, Yunfang Wang, Guido Carpino, Cai‐Bin Cui, Manuela Gatto, Massimo Rossi, Pasquale Bartolomeo Berloco, Alfredo Cantafora, Eliane Wauthier, Mark E. Furth, Luca Inverardi, Juan Dominguez‐Bendala, Camillo Ricordi, David Gerber, Eugenio Gaudio, Domenico Alvaro, Lola Reid – 2 December 2011 – Multipotent stem/progenitors are present in peribiliary glands of extrahepatic biliary trees from humans of all ages and in high numbers in hepato‐pancreatic common duct, cystic duct, and hilum.

Alexandru V. Olaru, Gabriel Ghiaur, Sumitaka Yamanaka, Delgermaa Luvsanjav, Fangmei An, Irinel Popescu, Sorin Alexandrescu, Sarah Allen, Timothy M. Pawlik, Michael Torbenson, Christos Georgiades, Lewis R. Roberts, Gregory J. Gores, Anne Ferguson‐Smith, Maria I. Almeida, George A. Calin, Esteban Mezey, Florin M. Selaru – 2 December 2011 – MicroRNAs (miRs) recently emerged as prominent regulators of cancer processes.

Richard E. Nettles, Min Gao, Marc Bifano, Ellen Chung, Anna Persson, Thomas C. Marbury, Ronald Goldwater, Michael P. DeMicco, Maribel Rodriguez‐Torres, Apinya Vutikullird, Ernesto Fuentes, Eric Lawitz, Juan Carlos Lopez‐Talavera, Dennis M. Grasela – 2 December 2011 – The antiviral activity, resistance profile, pharmacokinetics (PK), safety, and tolerability of BMS‐790052, a nonstructural protein 5A (NS5A) replication complex inhibitor, were evaluated in a double‐blind, placebo‐controlled, sequential panel, multiple ascending dose study.

Tobias J. Weismüller, Gabriele I. Kirchner, Marcus N. Scherer, Ahmed A. Negm, Andreas A. Schnitzbauer, Frank Lehner, Jürgen Klempnauer, Hans J. Schlitt, Michael P. Manns, Christian P. Strassburg – 2 December 2011 – Serum ferritin (SF) concentration is a widely available parameter used to assess iron homeostasis. It has been described as a marker to identify high‐risk patients awaiting liver transplantation (LT) but is also elevated in systemic immune‐mediated diseases, metabolic syndrome, and in hemodialysis where it is associated with an inferior prognosis.

Chuanghong Wu, Richard Gilroy, Ryan Taylor, Mojtaba Olyaee, Bashar Abdulkarim, Jameson Forster, Maura O'Neil, Ivan Damjanov, Yu‐Jui Yvonne Wan – 2 December 2011 – The current study tests a hypothesis that nuclear receptor signaling is altered in chronic hepatitis C patients and that the altered pattern is specific to alcohol drinking history. The expression of a panel of more than 100 genes encoding nuclear receptors, coregulators, and their direct/indirect targets was studied in human livers.