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Philip Starkey Lewis, James Dear, Vivien Platt, Jonathan Moggs, Chris Goldring, B. Kevin Park – 27 December 2011
Prioritizing treatment experienced patients with hepatitis C infection for treatment with telaprevir: A number needed to treat approach
Ian A. Rowe, Matthew J. Armstrong, Diarmaid D. Houlihan – 27 December 2011
Zinc finger transcription factor 191, directly binding to β‐catenin promoter, promotes cell proliferation of hepatocellular carcinoma
Guoyuan Liu, Songmin Jiang, Chenji Wang, Wei Jiang, Zulong Liu, Chao Liu, Hexige Saiyin, Xianmei Yang, Suqin Shen, Deke Jiang, Ping Zhou, Dingding Han, Xiaohui Hu, Qing Yi, Long Yu – 27 December 2011 – Activation of β‐catenin, the central effector of the canonical wingless‐type (Wnt) pathway, has been implicated in hepatocellular carcinoma (HCC). However, the transcription regulation mechanism of the β‐catenin gene in HCC remains unknown. Here we report that human zinc finger protein 191 (ZNF191) is a potential regulator of β‐catenin transcription.
Clinical trials and their translation in hepatology: Past, present, and future
E. Jenny Heathcote – 27 December 2011
Gilbert syndrome redefined: A complex genetic haplotype influences the regulation of glucuronidation
Ursula Ehmer, Sandra Kalthoff, Bastian Fakundiny, Brigitte Pabst, Nicole Freiberg, Ronald Naumann, Michael P. Manns, Christian P. Strassburg – 27 December 2011 – Gilbert syndrome (GS) is characterized by intermittent unconjugated hyperbilirubinemia without structural liver damage, affecting about 10% of the white population. In GS the UGT1A1*28 variant reduces bilirubin conjugation by 70% and is associated with irinotecan and protease inhibitor side effects. The aim of this study was to characterize potential in vivo consequences of UGT1A gene variability in GS.
Galectin‐3 deficiency prevents concanavalin A–induced hepatitis in mice
Vladislav Volarevic, Marija Milovanovic, Biljana Ljujic, Nada Pejnovic, Nebojsa Arsenijevic, Ulf Nilsson, Hakon Leffler, Miodrag L. Lukic – 24 December 2011 – We used concanavalin A (Con A)‐induced liver injury to study the role of galectin‐3 (Gal‐3) in the induction of inflammatory pathology and hepatocellular damage.
Outcomes after liver transplantation for alcoholic hepatitis are similar to alcoholic cirrhosis: Exploratory analysis from the UNOS database
Ashwani K. Singal, Hmoud Bashar, Bhupinderjit S. Anand, Sarat C. Jampana, Vineet Singal, Yong‐Fang Kuo – 24 December 2011 – Data on liver transplantation for patients with alcoholic hepatitis are limited. Using the United Network for Organ Sharing database (2004‐2010), adults undergoing liver transplantation for a listing diagnosis of alcoholic hepatitis were matched for age, gender, ethnicity, and model for endstage disease (MELD) score, donor risk index, and year of transplantation with three patients transplanted for a listing diagnosis of alcoholic cirrhosis.
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Massimo Iavarone, Giuseppe Cabibbo, Massimo Colombo – 24 December 2011
Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease
Shelby Sullivan, Erik P. Kirk, Bettina Mittendorfer, Bruce W. Patterson, Samuel Klein – 24 December 2011 – Nonalcoholic fatty liver disease (NAFLD) and alterations in hepatic lipoprotein kinetics are common metabolic complications associated with obesity. Lifestyle modification involving diet‐induced weight loss and regular exercise decreases intrahepatic triglyceride (IHTG) content and very low density lipoprotein (VLDL) triglyceride (TG) secretion rate.
Argininosuccinate synthase conditions the response to acute and chronic ethanol‐induced liver injury in mice
Tung Ming Leung, Yongke Lu, Wei Yan, José A. Morón‐Concepción, Stephen C. Ward, Xiaodong Ge, Laura Conde de la Rosa, Natalia Nieto – 24 December 2011 – Argininosuccinate synthase (ASS) is the rate‐limiting enzyme in both the urea and the L‐citrulline/nitric oxide (NO·) cycles regulating protein catabolism, ammonia levels, and NO· generation.