Chun‐Ming Wong, Carmen Chak‐Lui Wong, Joyce Man‐Fong Lee, Dorothy Ngo‐Yin Fan, Sandy Leung‐Kuen Au, Irene Oi‐Lin Ng – 2 December 2011 – Hepatocellular carcinoma (HCC) is a prevalent cancer with an extremely high mortality rate attributed to HCC metastasis, which is the major cause of tumor recurrence and organ failure. Presence of tumor thrombi in the portal veins (venous metastases) is a clinicopathological feature of metastatic HCCs.

Ashish Goel, Banumathi Ramakrishna, Kadiyala Madhu, Uday Zachariah, Jeyamani Ramachandran, Shyamkumar N. Keshava, Elwyn Elias, Chundamannil E. Eapen – 2 December 2011

Yang Liu, Shengdian Wang, Fusheng Wang, Dongling Li, Linghua Zheng, Pan Zheng – 2 December 2011

Keith D. Lindor, M.D. – 2 December 2011

Pranoti Mandrekar, Aditya Ambade, Arlene Lim, Gyongyi Szabo, Donna Catalano – 2 December 2011 – The importance of chemokines in alcoholic liver injury has been implicated. The role of the chemokine, monocyte chemoattractant protein‐1 (MCP‐1), elevated in patients with alcoholic liver disease is not yet understood. Here, we evaluated the pathophysiological significance of MCP‐1 and its receptor, chemokine (C‐C motif) receptor 2 (CCR2), in alcoholic liver injury.

Svetlana Marukian, Linda Andrus, Timothy P. Sheahan, Christopher T. Jones, Edgar D. Charles, Alexander Ploss, Charles M. Rice, Lynn B. Dustin – 2 December 2011 – Hepatitis C virus (HCV) replication in primary liver cells is less robust than that in hepatoma cell lines, suggesting that innate antiviral mechanisms in primary cells may limit HCV replication or spread. Here we analyzed the expression of 47 genes associated with interferon (IFN) induction and signaling following HCV infection of primary human fetal liver cell (HFLC) cultures from 18 different donors.

Emmanuel A. Tsochatzis, Giacomo Germani, Amar P. Dhillon, Andrew K. Burroughs – 2 December 2011

Ji‐hang Yuan, Fu Yang, Bi‐feng Chen, Zhi Lu, Xi‐song Huo, Wei‐ping Zhou, Fang Wang, Shu‐han Sun – 2 December 2011 – As an important epigenetic mechanism, histone acetylation modulates the transcription of many genes and plays important roles in hepatocellular carcinoma (HCC). Aberrations in histone acetylation have been observed in HCC, but the factors that contribute to the aberrations have not been fully elucidated. MicroRNAs (miRNAs), which are noncoding RNAs that regulate gene expression, are involved in important epigenetic mechanisms.

Pu Zhao, Wei Zhang, Shi‐Jie Wang, Xiao‐Ling Yu, Juan Tang, Wan Huang, Yong Li, Hong‐Yong Cui, Yun‐Shan Guo, Jan Tavernier, Si‐He Zhang, Jian‐Li Jiang, Zhi‐Nan Chen – 2 December 2011 – Tumor cells can move as individual cells in two interconvertible modes: mesenchymal mode and amoeboid mode. Cytoskeleton rearrangement plays an important role in the interconversion. Previously, we reported that HAb18G/CD147 and annexin II are interacting proteins involved in cytoskeleton rearrangement, yet the role of their interaction is unclear.

2 December 2011 – Retraction: The following editorial from HEPATOLOGY, “I148M PNPLA3 variant and progressive liver disease: A new paradigm in hepatology”, by Luca Valenti, Anna Alisi and Valerio Nobili, posted online on 2 December 2011 as an Accepted Article in Wiley Online Library (www.wileyonlinelibrary.com), has been retracted by agreement between the authors, the AASLD, the journal Editor in Chief, Michael H. Nathanson, and Wiley Periodicals, Inc. The retraction has been agreed due to the fact that an incorrect version was posted online.