Scavenger receptor a restrains T‐cell activation and protects against concanavalin A‐induced hepatic injury

Daming Zuo, Xiaofei Yu, Chunqing Guo, Hongxia Wang, Jie Qian, Huanfa Yi, Xiao Lu, Zhi‐Ping Lv, John R. Subjeck, Huiping Zhou, Arun J. Sanyal, Zhengliang Chen, Xiang‐Yang Wang – 23 July 2012 – Negative feedback immune mechanisms are essential for maintenance of hepatic homeostasis and prevention of immune‐mediated liver injury. We show here that scavenger receptor A (SRA/CD204), a pattern recognition molecule, is highly up‐regulated in the livers of patients with autoimmune or viral hepatitis, and of mice during concanavalin A (Con A)‐induced hepatitis (CIH).

A randomized controlled trial of pretransplant antiviral therapy to prevent recurrence of hepatitis C after liver transplantation

Gregory T. Everson, Norah A. Terrault, Anna S. Lok, Del R. Rodrigo, Robert S. Brown, Sammy Saab, Mitchell L. Shiffman, Abdullah M.S. Al‐Osaimi, Laura M. Kulik, Brenda W. Gillespie, James E. Everhart, and the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study – 23 July 2012 – Hepatitis C virus (HCV) infection recurs in liver recipients who are viremic at transplantation. We conducted a randomized, controlled trial to test the efficacy and safety of pretransplant pegylated interferon alpha‐2b plus ribavirin (Peg‐IFN‐α2b/RBV) for prevention of post‐transplant HCV recurrence.

Epinephrine and phenylephrine pretreatments for preventing postreperfusion syndrome during adult liver transplantation

Ho‐Geol Ryu, Chul‐Woo Jung, Hyung‐Chul Lee, Youn‐Joung Cho – 23 July 2012 – Acute hypotension after reperfusion of the liver graft occurs frequently during liver transplantation. A randomized, prospective trial was performed to test the effects of epinephrine and phenylephrine pretreatments for attenuating postreperfusion syndrome (PRS). Ninety‐three adult liver recipients were randomly allocated to receive an intravenous bolus of 10 μg of epinephrine, 100 μg of phenylephrine, or normal saline (the control group) at the time of graft reperfusion.

Subscribe to