Identification of endogenous normalizers for serum MicroRNAs by microarray profiling: U6 small nuclear RNA is not a reliable normalizer
Ruiqun Qi, Matthew Weiland, Xing‐Hua Gao, Li Zhou, Qing‐Sheng Mi – 27 December 2011
An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish
Liangliang Xu, Wenguang Yin, Jianhong Xia, Meixiu Peng, Song Li, Shuo Lin, Duanqing Pei, Xiaodong Shu – 27 December 2011
Cognitive dysfunction in cirrhosis is associated with falls: A prospective study
Germán Soriano, Eva Román, Joan Córdoba, Maria Torrens, Maria Poca, Xavier Torras, Càndid Villanueva, Ignasi J. Gich, Víctor Vargas, Carlos Guarner – 27 December 2011 – Falls are frequent among patients with debilitating disorders and can have a serious effect on health status. Mild cognitive disturbances associated with cirrhosis may increase the risk for falls. Identifying subjects at risk may allow the implementation of preventive measures. Our aim was to assess the predictive value of the Psychometric Hepatic Encephalopathy Score (PHES) in identifying patients likely to sustain falls.
Awareness of infection, knowledge of hepatitis C, and medical follow‐up among individuals testing positive for hepatitis C: National Health and Nutrition Examination Survey 2001‐2008
Maxine M. Denniston, R. Monina Klevens, Geraldine M. McQuillan, Ruth B. Jiles – 27 December 2011 – Many persons infected with hepatitis C virus (HCV) are unknown to the healthcare system because they may be asymptomatic for years, have not been tested for HCV infection, and only seek medical care when they develop liver‐related complications. We analyzed data from persons who tested positive for past or current HCV infection during participation in the National Health and Nutrition Examination Survey (NHANES) from 2001 through 2008.
Phytosterol and cholesterol precursor levels indicate increased cholesterol excretion and biosynthesis in gallstone disease
Marcin Krawczyk, Dieter Lütjohann, Ramin Schirin‐Sokhan, Luis Villarroel, Flavio Nervi, Fernando Pimentel, Frank Lammert, Juan Francisco Miquel – 27 December 2011 – In hepatocytes and enterocytes sterol uptake and secretion is mediated by Niemann‐Pick C1‐like 1 (NPC1L1) and ATP‐binding cassette (ABC)G5/8 proteins, respectively. Whereas serum levels of phytosterols represent surrogate markers for intestinal cholesterol absorption, cholesterol precursors reflect cholesterol biosynthesis.
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Philip Starkey Lewis, James Dear, Vivien Platt, Jonathan Moggs, Chris Goldring, B. Kevin Park – 27 December 2011
Prioritizing treatment experienced patients with hepatitis C infection for treatment with telaprevir: A number needed to treat approach
Ian A. Rowe, Matthew J. Armstrong, Diarmaid D. Houlihan – 27 December 2011
Zinc finger transcription factor 191, directly binding to β‐catenin promoter, promotes cell proliferation of hepatocellular carcinoma
Guoyuan Liu, Songmin Jiang, Chenji Wang, Wei Jiang, Zulong Liu, Chao Liu, Hexige Saiyin, Xianmei Yang, Suqin Shen, Deke Jiang, Ping Zhou, Dingding Han, Xiaohui Hu, Qing Yi, Long Yu – 27 December 2011 – Activation of β‐catenin, the central effector of the canonical wingless‐type (Wnt) pathway, has been implicated in hepatocellular carcinoma (HCC). However, the transcription regulation mechanism of the β‐catenin gene in HCC remains unknown. Here we report that human zinc finger protein 191 (ZNF191) is a potential regulator of β‐catenin transcription.
Clinical trials and their translation in hepatology: Past, present, and future
E. Jenny Heathcote – 27 December 2011
Gilbert syndrome redefined: A complex genetic haplotype influences the regulation of glucuronidation
Ursula Ehmer, Sandra Kalthoff, Bastian Fakundiny, Brigitte Pabst, Nicole Freiberg, Ronald Naumann, Michael P. Manns, Christian P. Strassburg – 27 December 2011 – Gilbert syndrome (GS) is characterized by intermittent unconjugated hyperbilirubinemia without structural liver damage, affecting about 10% of the white population. In GS the UGT1A1*28 variant reduces bilirubin conjugation by 70% and is associated with irinotecan and protease inhibitor side effects. The aim of this study was to characterize potential in vivo consequences of UGT1A gene variability in GS.