Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease

Shelby Sullivan, Erik P. Kirk, Bettina Mittendorfer, Bruce W. Patterson, Samuel Klein – 24 December 2011 – Nonalcoholic fatty liver disease (NAFLD) and alterations in hepatic lipoprotein kinetics are common metabolic complications associated with obesity. Lifestyle modification involving diet‐induced weight loss and regular exercise decreases intrahepatic triglyceride (IHTG) content and very low density lipoprotein (VLDL) triglyceride (TG) secretion rate.

Argininosuccinate synthase conditions the response to acute and chronic ethanol‐induced liver injury in mice

Tung Ming Leung, Yongke Lu, Wei Yan, José A. Morón‐Concepción, Stephen C. Ward, Xiaodong Ge, Laura Conde de la Rosa, Natalia Nieto – 24 December 2011 – Argininosuccinate synthase (ASS) is the rate‐limiting enzyme in both the urea and the L‐citrulline/nitric oxide (NO·) cycles regulating protein catabolism, ammonia levels, and NO· generation.

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Bruno Sangro, for the European Network on Radioembolization With Yttrium‐90 Resin Microspheres – 24 December 2011

Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end‐stage liver disease score for the prognosis of acetaminophen‐induced acute liver failure

Evangelos Cholongitas, Eleni Theocharidou, Panayota Vasianopoulou, Alex Betrosian, Steve Shaw, David Patch, James O'Beirne, Banwari Agarwal, Andrew K. Burroughs – 23 December 2011 – Acetaminophen‐induced acute liver failure (ALF) is a complex multiorgan illness. An assessment of the prognosis is essential for the accurate identification of patients for whom survival without liver transplantation (LT) is unlikely.

Retinoic acid receptor–related orphan receptor α–induced activation of adenosine monophosphate–activated protein kinase results in attenuation of hepatic steatosis

Eun‐Jin Kim, Young‐Sil Yoon, Suckchang Hong, Ho‐Young Son, Tae‐Young Na, Min‐Ho Lee, Hyun‐Jin Kang, Jinyoung Park, Won‐Jea Cho, Sang‐Gun Kim, Seung‐Hoi Koo, Hyeung‐geun Park, Mi‐Ock Lee – 20 December 2011 – There is increasing evidence that the retinoic acid receptor–related orphan receptor α (RORα) plays an important role in the regulation of metabolic pathways, particularly of fatty acid and cholesterol metabolism; however, the role of RORα in the regulation of hepatic lipogenesis has not been studied.

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