Impact of the etiology of acute kidney injury on outcomes following liver transplantation: acute tubular necrosis versus hepatorenal syndrome

Mitra K. Nadim, Yuri S. Genyk, Chris Tokin, Jenny Fieber, Wanwarat Ananthapanyasut, Wei Ye, Rick Selby – 17 January 2012 – Acute kidney injury (AKI) at the time of liver transplantation (LT) has been associated with increased morbidity and mortality. In patients with potentially reversible renal dysfunction, predicting whether there will be sufficient return of native kidney function is sometimes difficult. Previous studies have focused mainly on the effect of the severity of renal dysfunction or the duration of pretransplant dialysis on posttransplant outcomes.

Standard hepatic vein reconstruction with patch plasty using the native portal vein in adult living donor liver transplantation

Akira Mori, Toshimi Kaido, Yasuhiro Ogura, Kohei Ogawa, Koichiro Hata, Shintaro Yagi, Atsushi Yoshizawa, Hiroyoshi Isoda, Toshiya Shibata, Shinji Uemoto – 17 January 2012 – An outflow obstruction of the hepatic vein is a critical complication after living donor liver transplantation (LDLT) and occasionally leads to hepatic failure. Here we introduce a simple method for preventing outflow obstructions by patch plasty in adult LDLT. Between September 2001 and May 2010, 468 adult LDLT procedures were performed at Kyoto University Hospital.

Duration of red blood cell storage and outcomes following orthotopic liver transplantation

Lauren K. Dunn, Robert H. Thiele, Jennie Z. Ma, Robert G. Sawyer, Edward C. Nemergut – 12 January 2012 – Liver transplantation may be complicated by massive intraoperative bleeding, and red blood cell (RBC) transfusions may be required. The storage duration or age of transfused RBCs has been shown to affect the morbidity and mortality of critically ill, trauma, and cardiac surgery patients. Here we investigate the effect of RBC age on the outcomes of liver transplant patients.

Chemokine Cxcl9 attenuates liver fibrosis‐associated angiogenesis in mice

Hacer Sahin, Erawan Borkham‐Kamphorst, Christoph Kuppe, Mirko Moreno Zaldivar, Christoph Grouls, Muhammad Al‐samman, Andreas Nellen, Petra Schmitz, Daniel Heinrichs, Marie‐Luise Berres, Dennis Doleschel, David Scholten, Ralf Weiskirchen, Marcus J. Moeller, Fabian Kiessling, Christian Trautwein, Hermann E. Wasmuth – 12 January 2012 – Recent data suggest that the chemokine receptor CXCR3 is functionally involved in fibroproliferative disorders, including liver fibrosis.

Implications of changing the minimal survival benefit in liver transplantation

Marina Knight, Kerri Barber, Alex Gimson, Dave Collett, James Neuberger, for the Liver Advisory Group of National Health Service Blood Transplant – 12 January 2012 – The limited availability of livers donated by deceased donors for transplantation means that not everyone who might benefit from the procedure can receive a graft, so any selection and allocation system must have clearly defined goals. The United Kingdom, in common with many other countries, has adopted a minimum benefit criterion of a greater than 50% probability of survival 5 years after transplantation.

Immunosuppression induction with rabbit anti‐thymocyte globulin with or without rituximab in 1000 liver transplant patients with long‐term follow‐up

Richard S. Mangus, Jonathan A. Fridell, Rodrigo M. Vianna, Paul Y. Kwo, Jeanne Chen, A. Joseph Tector – 12 January 2012 – Rabbit anti‐thymocyte globulin (rATG)–based immunosuppression induction is being increasingly used in liver transplantation (LT) in conjunction with steroid‐free protocols to delay the initiation of calcineurin inhibitors. This study reports a single‐center comparison of transplant outcomes and complications in 3 immunosuppression eras. Data were obtained retrospectively from a center research database, and the analysis included LT patients from 2001 to 2008.

Adrenocortical dysfunction in liver disease: A systematic review

Giuseppe Fede, Luisa Spadaro, Tania Tomaselli, Graziella Privitera, Giacomo Germani, Emmanuel Tsochatzis, Michael Thomas, Pierre‐Marc Bouloux, Andrew K. Burroughs, Francesco Purrello – 11 January 2012 – In patients with cirrhosis, adrenal insufficiency (AI) is reported during sepsis and septic shock and is associated with increased mortality. Consequently, the term “hepato‐adrenal syndrome” was proposed. Some studies have shown that AI is frequent in stable cirrhosis as well as in cirrhosis associated with decompensation other than sepsis, such as bleeding and ascites.

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