Effects of ethnicity and socioeconomic status on survival and severity of fibrosis in liver transplant recipients with hepatitis C virus

Elizabeth C. Verna, Rosa Valadao, Erica Farrand, Elsa M. Pichardo, Jennifer C. Lai, Norah A. Terrault, Robert S. Brown – 4 January 2012 – The ethnicity and socioeconomic status of the host may affect the progression of hepatitis C virus (HCV). We aimed to compare survival and fibrosis progression in Hispanic white (HW) and non‐Hispanic white (NHW) recipients of liver transplantation (LT) with HCV. All HW and NHW patients with HCV who underwent transplantation between January 2000 and December 2007 at 2 centers were retrospectively assessed.

Mortality associated with carbapenem‐resistant Klebsiella pneumoniae infections in liver transplant recipients

Jayant S. Kalpoe, Edith Sonnenberg, Stephanie H. Factor, Juan del Rio Martin, Thomas Schiano, Gopi Patel, Shirish Huprikar – 4 January 2012 – Resistant bacterial infections are important causes of morbidity and mortality after liver transplantation (LT). This was a retrospective cohort study evaluating the outcomes associated with carbapenem‐resistant Klebsiella pneumoniae (CRKP) infections after LT. In a 2005‐2006 cohort of 175 consecutive LT recipients, 91 infection episodes were observed in 61 patients (35%). The mortality rate 1 year after LT was 18% (32/175).

Risk factors and outcomes of failed endoscopic retrograde cholangiopancreatography in liver transplant recipients with anastomotic biliary strictures: A case‐control study

Domingo Balderramo, Oriol Sendino, Marta Burrel, Maria Isabel Real, Annabel Blasi, Graciela Martinez‐Palli, Josep M. Bordas, Juan Carlos Garcia‐Valdecasas, Antoni Rimola, Miguel Navasa, Josep Llach, Andres Cardenas – 4 January 2012 – Anastomotic strictures (ASs) of the biliary duct after liver transplantation (LT) are primarily managed with endoscopic retrograde cholangiopancreatography (ERCP), but in some cases, this fails because of difficulties in passing the strictures.

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Philip Starkey Lewis, James Dear, Vivien Platt, Jonathan Moggs, Chris Goldring, B. Kevin Park – 27 December 2011

Phytosterol and cholesterol precursor levels indicate increased cholesterol excretion and biosynthesis in gallstone disease

Marcin Krawczyk, Dieter Lütjohann, Ramin Schirin‐Sokhan, Luis Villarroel, Flavio Nervi, Fernando Pimentel, Frank Lammert, Juan Francisco Miquel – 27 December 2011 – In hepatocytes and enterocytes sterol uptake and secretion is mediated by Niemann‐Pick C1‐like 1 (NPC1L1) and ATP‐binding cassette (ABC)G5/8 proteins, respectively. Whereas serum levels of phytosterols represent surrogate markers for intestinal cholesterol absorption, cholesterol precursors reflect cholesterol biosynthesis.

Awareness of infection, knowledge of hepatitis C, and medical follow‐up among individuals testing positive for hepatitis C: National Health and Nutrition Examination Survey 2001‐2008

Maxine M. Denniston, R. Monina Klevens, Geraldine M. McQuillan, Ruth B. Jiles – 27 December 2011 – Many persons infected with hepatitis C virus (HCV) are unknown to the healthcare system because they may be asymptomatic for years, have not been tested for HCV infection, and only seek medical care when they develop liver‐related complications. We analyzed data from persons who tested positive for past or current HCV infection during participation in the National Health and Nutrition Examination Survey (NHANES) from 2001 through 2008.

Cognitive dysfunction in cirrhosis is associated with falls: A prospective study

Germán Soriano, Eva Román, Joan Córdoba, Maria Torrens, Maria Poca, Xavier Torras, Càndid Villanueva, Ignasi J. Gich, Víctor Vargas, Carlos Guarner – 27 December 2011 – Falls are frequent among patients with debilitating disorders and can have a serious effect on health status. Mild cognitive disturbances associated with cirrhosis may increase the risk for falls. Identifying subjects at risk may allow the implementation of preventive measures. Our aim was to assess the predictive value of the Psychometric Hepatic Encephalopathy Score (PHES) in identifying patients likely to sustain falls.

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