Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma

Ming Liu, Leilei Chen, Tim Hon Man Chan, Jian Wang, Yan Li, Yan Li, Ting‐Ting Zeng, Yun‐Fei Yuan, Xin‐Yuan Guan – 19 January 2012 – Amplification of broad regions of 8q is one of the most frequent genetic alterations in hepatocellular carcinoma (HCC), suggesting the existence of oncogenes in addition to MYC at 8q24.21. In this report we examine the potential role of the candidate amplified oncogene serum and glucocorticoid kinase 3 (SGK3) at 8q13.1 in HCC pathogenesis.

Standard hepatic vein reconstruction with patch plasty using the native portal vein in adult living donor liver transplantation

Akira Mori, Toshimi Kaido, Yasuhiro Ogura, Kohei Ogawa, Koichiro Hata, Shintaro Yagi, Atsushi Yoshizawa, Hiroyoshi Isoda, Toshiya Shibata, Shinji Uemoto – 17 January 2012 – An outflow obstruction of the hepatic vein is a critical complication after living donor liver transplantation (LDLT) and occasionally leads to hepatic failure. Here we introduce a simple method for preventing outflow obstructions by patch plasty in adult LDLT. Between September 2001 and May 2010, 468 adult LDLT procedures were performed at Kyoto University Hospital.

Impact of the etiology of acute kidney injury on outcomes following liver transplantation: acute tubular necrosis versus hepatorenal syndrome

Mitra K. Nadim, Yuri S. Genyk, Chris Tokin, Jenny Fieber, Wanwarat Ananthapanyasut, Wei Ye, Rick Selby – 17 January 2012 – Acute kidney injury (AKI) at the time of liver transplantation (LT) has been associated with increased morbidity and mortality. In patients with potentially reversible renal dysfunction, predicting whether there will be sufficient return of native kidney function is sometimes difficult. Previous studies have focused mainly on the effect of the severity of renal dysfunction or the duration of pretransplant dialysis on posttransplant outcomes.

Liver transplantation in septuagenarians receiving model for end‐stage liver disease exception points for hepatocellular carcinoma: The national experience

Jason J. Schwartz, Lisa Pappas, Heather F. Thiesset, Gabriela Vargas, John B. Sorensen, Robin D. Kim, William R. Hutson, Kenneth Boucher, Terry Box – 17 January 2012 – Current liver allocation policy in the United States grants liver transplant candidates with stage T2 hepatocellular carcinoma (HCC) a priority Model for End‐Stage Liver Disease (MELD) score of 22, regardless of age.

Immunosuppression induction with rabbit anti‐thymocyte globulin with or without rituximab in 1000 liver transplant patients with long‐term follow‐up

Richard S. Mangus, Jonathan A. Fridell, Rodrigo M. Vianna, Paul Y. Kwo, Jeanne Chen, A. Joseph Tector – 12 January 2012 – Rabbit anti‐thymocyte globulin (rATG)–based immunosuppression induction is being increasingly used in liver transplantation (LT) in conjunction with steroid‐free protocols to delay the initiation of calcineurin inhibitors. This study reports a single‐center comparison of transplant outcomes and complications in 3 immunosuppression eras. Data were obtained retrospectively from a center research database, and the analysis included LT patients from 2001 to 2008.

Implications of changing the minimal survival benefit in liver transplantation

Marina Knight, Kerri Barber, Alex Gimson, Dave Collett, James Neuberger, for the Liver Advisory Group of National Health Service Blood Transplant – 12 January 2012 – The limited availability of livers donated by deceased donors for transplantation means that not everyone who might benefit from the procedure can receive a graft, so any selection and allocation system must have clearly defined goals. The United Kingdom, in common with many other countries, has adopted a minimum benefit criterion of a greater than 50% probability of survival 5 years after transplantation.

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