Cellular‐specific role of toll‐like receptor 4 in hepatic ischemia‐reperfusion injury in mice

Gary W. Nace, Hai Huang, John R. Klune, Raymond E. Eid, Brian R. Rosborough, Sebastian Korff, Shen Li, Richard A. Shapiro, Donna B. Stolz, Chhinder P. Sodhi, David J. Hackam, David A. Geller, Timothy R. Billiar, Allan Tsung – 4 March 2013 – Ischemia‐reperfusion (I/R) injury is a process whereby an initial hypoxic insult and subsequent return of blood flow leads to the propagation of innate immune responses and organ injury. The necessity of the pattern recognition receptor, Toll‐like receptor (TLR)4, for this innate immune response has been previously shown.

Persistent abnormal liver fibrosis after weaning off parenteral nutrition in pediatric intestinal failure

Annika Mutanen, Jouko Lohi, Päivi Heikkilä, Antti I. Koivusalo, Risto J. Rintala, Mikko P. Pakarinen – 4 March 2013 – The aim of this study was to evaluate the long‐term effects of pediatric intestinal failure (IF) on liver histology. Altogether, 38 IF patients (median age: 7.2 years; range, 0.2‐27) underwent liver biopsy, gastroscopy, abdominal ultrasound, and laboratory tests. Sixteen patients were on parenteral nutrition (PN) after 74 PN months (range, 2.5‐204). Twenty‐two had weaned off PN 8.8 years (range, 0.3‐27) earlier, after 35 PN months (range, 0.7‐250).

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