Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes

Mina Komuta, Olivier Govaere, Vincent Vandecaveye, Jun Akiba, Werner Van Steenbergen, Chris Verslype, Wim Laleman, Jacques Pirenne, Raymond Aerts, Hirohisa Yano, Frederik Nevens, Baki Topal, Tania Roskams – 23 January 2012 – Cholangiocellular carcinoma (CC) originates from topographically heterogeneous cholangiocytes. The cylindrical mucin‐producing cholangiocytes are located in large bile ducts and the cuboidal non–mucin‐producing cholangiocytes are located in ductules containing bipotential hepatic progenitor cells (HPCs).

Nonalcoholic fatty liver disease is associated with coronary artery calcification

Donghee Kim, Su‐Yeon Choi, Eun Ha Park, Whal Lee, Jin Hwa Kang, Won Kim, Yoon Jun Kim, Jung‐Hwan Yoon, Sook Hyang Jeong, Dong Ho Lee, Hyo‐suk Lee, Joseph Larson, Terry M. Therneau, W. Ray Kim – 23 January 2012 – Nonalcoholic fatty liver disease (NAFLD) is related to risk factors of coronary artery disease, such as dyslipidemia, diabetes, and metabolic syndrome, which are closely linked with visceral adiposity.

Risk of advanced fibrosis with grafts from hepatitis C antibody–positive donors: A multicenter cohort study

Jennifer C. Lai, Jacqueline G. O'Leary, James F. Trotter, Elizabeth C. Verna, Robert S. Brown, R. Todd Stravitz, Jeffrey D. Duman, Lisa M. Forman, Norah A. Terrault, for the Consortium to Study Health Outcomes in HCV Liver Transplant Recipients (CRUSH‐C) – 23 January 2012 – Over the last decade, the use of liver grafts from hepatitis C virus antibody–positive donors [HCV(+)Ds] has tripled in the United States. Although previous studies have demonstrated no association between an HCV(+)D status and graft loss, the effects of an HCV(+)D on histological outcomes are not well known.

A New procedure for temporary auxiliary partial liver transplantation using living donor graft for patients with familial amyloid polyneuropathy

Yasunari Ohno, Akira Kobayashi, Toshihiko Ikegami, Yuichi Masuda, Atsuyoshi Mita, Koichi Urata, Yuichi Nakazawa, Masaru Terada, Shu‐ichi Ikeda, Shinichi Miyagawa – 23 January 2012 – To introduce duct‐to‐duct biliary anastomosis to conventional temporary auxiliary partial orthotopic liver transplantation (APOLT) using living donor graft for patients with familial amyloid polyneuropathy, we modified the conventional APOLT procedure in a manner characterized by the use of the recipient's common hepatic duct for biliary reconstruction and the preservation of the right posterior section alone fo

Impact of nighttime and weekend liver transplants on graft and patient outcomes

Eric S. Orman, Paul H. Hayashi, Evan S. Dellon, David A. Gerber, A. Sidney Barritt – 23 January 2012 – Safety concerns have been raised about nighttime and weekend patient care, but it is unknown whether these issues affect liver transplantation. We sought to identify the impact of nighttime and weekend liver transplants on graft and patient survival. We used the United Network for Organ Sharing database to review adult liver transplants from 1987 to 2010. Comparisons were made between nighttime and daytime operations and between weekday and weekend operations.

The inhibitors of nucleotide biosynthesis leflunomide, FK778, and mycophenolic acid activate hepatitis B virus replication in vitro

Karin Hoppe‐Seyler, Peter Sauer, Claudia Lohrey, Felix Hoppe‐Seyler – 23 January 2012 – The inhibitors of pyrimidine synthesis, leflunomide and FK778, have been reported to exert broad antiviral effects, in addition to their immunosuppressive activities. Their possible therapeutic benefit for transplantation medicine is currently discussed, because they also block the replication of human cytomegalovirus and human polyomavirus BK, which both cause important complications in transplant recipients.

Transient elastography identifies liver recipients with nonviral graft disease after transplantation: A guide for liver biopsy

Cristina Rigamonti, Mirella Fraquelli, Anan Judina Bastiampillai, Lucio Caccamo, Paolo Reggiani, Giorgio Rossi, Massimo Colombo, Maria Francesca Donato – 23 January 2012 – Transient elastography (TE) reliably predicts the severity of recurrent hepatitis C virus after orthotopic liver transplantation (OLT); however, its accuracy in evaluating nonviral liver graft damage is unknown.

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