Single determination of C‐reactive protein at the time of diagnosis predicts long‐term outcome of patients with hepatocellular carcinoma

Wolfgang Sieghart, Matthias Pinter, Florian Hucke, Ivo Graziadei, Maximilian Schöniger‐Hekele, Christian Müller, Wolfgang Vogel, Michael Trauner, Markus Peck‐Radosavljevic – 7 September 2012 – We investigated the prognostic value of C‐reactive protein (CRP) in patients with hepatocellular carcinoma (HCC) not amenable to surgery. A total of 615 patients diagnosed with HCC not amenable to surgery between April 1999 and December 2009 at the Department of Gastroenterology of the Medical Universities of Vienna and Innsbruck were included.

Hepatic and Abdominal Carbon Dioxide Measurements Detect and Distinguish Hepatic Artery Occlusion and Portal Vein Occlusion in Pigs

Soeren Erik Pischke, Christian Tronstad, Lars Holhjem, Pål Dag Line, Håkon Haugaa, Tor Inge Tønnessen – 7 September 2012 – Hepatic artery (HA) occlusion and portal vein (PV) occlusion are the most common vascular complications after liver transplantation with an impact on mortality and retransplantation rates. The detection of severe hypoperfusion may be delayed with currently available diagnostic tools. Hypoperfusion and anaerobically produced lactic acid lead to increases in tissue carbon dioxide.

Reduced hepatic stellate cell expression of kruppel‐like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury

Zahra Ghiassi‐Nejad, Virginia Hernandez‐Gea, Christopher Woodrell, Ursula E. Lang, Katja Dumic, Allison Kwong, Scott L. Friedman – 7 September 2012 – Kruppel‐like factor 6 (KLF6), a zinc finger transcription factor and tumor suppressor, is induced as an immediate‐early gene during hepatic stellate cell (HSC) activation. The paradoxical induction of a tumor suppressor in HSCs during proliferation led us to explore the biology of wildtype KLF6 (KLF6WT) and its antagonistic, alternatively spliced isoform KLF6SV1 in cultured HSCs and animal models.

Living donor liver transplantation using grafts with hepatic cysts

Seisuke Sakamoto, Shunsuke Nosaka, Takanobu Shigeta, Hajime Uchida, Ikumi Hamano, Chiaki Karaki, Hiroyuki Kanazawa, Akinari Fukuda, Atsuko Nakazawa, Mureo Kasahara – 7 September 2012 – Cystic lesions in the liver are often found through the evaluation of liver donors. Multiple cysts are worrisome, and donor candidates with multiple cysts may be unacceptable as liver donors, especially when their recipients have fibrocystic disease (FCD), which is an inherited disorder. This study reviewed 183 cases of living donor liver transplantation.

Roles of hepatocyte and myeloid CXC chemokine receptor‐2 in liver recovery and regeneration after ischemia/reperfusion in mice

Heather L. Van Sweringen, Nozomu Sakai, Ralph C. Quillin, Jeff Bailey, Rebecca Schuster, John Blanchard, Holly Goetzman, Charles C. Caldwell, Michael J. Edwards, Alex B. Lentsch – 7 September 2012 – Previous studies have demonstrated the significance of signaling through the CXC chemokine receptor‐2 (CXCR2) receptor in the process of recovery and regeneration of functional liver mass after hepatic ischemia/reperfusion (I/R). CXCR2 is constitutively expressed on both neutrophils and hepatocytes; however, the cell‐specific roles of this receptor are unknown.

Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease

Mercedes Vazquez‐Chantada, Aintzane Gonzalez‐Lahera, Ibon Martinez‐Arranz, Carmelo Garcia‐Monzon, Manuela M. Regueiro, Juan L. Garcia‐Rodriguez, Karin A. Schlangen, Iñaki Mendibil, Naiara Rodriguez‐Ezpeleta, Juan J. Lozano, Karina Banasik, Johanne M. Justesen, Torben Joergensen, Daniel R. Witte, Torsten Lauritzen, Torben Hansen, Oluf Pedersen, Nicolas Veyrie, Karine Clement, Joan Tordjman, Albert Tran, Yannik Le Marchand‐Brustel, Xabier Buque, Patricia Aspichueta, Jose J. Echevarria‐Uraga, Antonio Martin‐Duce, Joan Caballeria, Philippe Gual, Azucena Castro, Jose M. Mato, Maria L.

Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype

Shadi Abu‐Hayyeh, Georgia Papacleovoulou, Anita Lövgren‐Sandblom, Mehreen Tahir, Olayiwola Oduwole, Nurul Akmal Jamaludin, Sabiha Ravat, Vanya Nikolova, Jenny Chambers, Clare Selden, Myrddin Rees, Hanns‐Ulrich Marschall, Malcolm G. Parker, Catherine Williamson – 7 September 2012 – Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent pregnancy‐specific liver disease and is associated with an increased risk of adverse fetal outcomes, including preterm labor and intrauterine death.

Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate

George A. Diaz, Lauren S. Krivitzky, Masoud Mokhtarani, William Rhead, James Bartley, Annette Feigenbaum, Nicola Longo, William Berquist, Susan A. Berry, Renata Gallagher, Uta Lichter‐Konecki, Dennis Bartholomew, Cary O. Harding, Stephen Cederbaum, Shawn E. McCandless, Wendy Smith, Gerald Vockley, Stephen A. Bart, Mark S. Korson, David Kronn, Roberto Zori, J. Lawrence Merritt, Sandesh C.S. Nagamani, Joseph Mauney, Cynthia LeMons, Klara Dickinson, Tristen L. Moors, Dion F. Coakley, Bruce F.

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