Influence of kinship on donors' mental burden in living donor liver transplantation

Yesim Erim, Mingo Beckmann, Sylvia Kroencke, Georgios C. Sotiropoulos, Andreas Paul, Wolfgang Senf, Karl‐Heinz Schulz – 24 July 2012 – In the context of living donor liver transplantation (LDLT), German transplantation law stipulates that donor candidates should primarily be relatives of the recipients or persons with distinct and close relationships. In this study, we investigated the influence of the relationship between the donor and the recipient on the donor's emotional strain before transplantation.

Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex

Ylva Bonde, Torsten Plösch, Folkert Kuipers, Bo Angelin, Mats Rudling – 24 July 2012 – Secretion of cholesterol into bile is important for the elimination of cholesterol from the body. Thyroid hormone (TH) increases biliary cholesterol secretion and hepatic gene expression of adenosine triphosphate (ATP)‐binding cassette, subfamily G (WHITE), member 5 (ABCG5) and ATP‐binding cassette, subfamily G (WHITE), member 8 (ABCG8), two half‐transporters that act as a heterodimeric complex promoting sterol secretion.

Liver grafts from CD39‐overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4+ T cells

Sandra Pommey, Bo Lu, Jennifer McRae, John Stagg, Prue Hill, Evelyn Salvaris, Simon C. Robson, Anthony J.F. d'Apice, Peter J. Cowan, Karen M. Dwyer – 24 July 2012 – Ischemia‐reperfusion injury (IRI) is a major limiting event for successful liver transplantation, and CD4+ T cells and invariant natural killer T (iNKT) cells have been implicated in promoting IRI. We hypothesized that hepatic overexpression of CD39, an ectonucleotidase with antiinflammatory functions, will protect liver grafts after prolonged cold ischemia.

MicroRNA‐221 overexpression accelerates hepatocyte proliferation during liver regeneration

Qinggong Yuan, Komal Loya, Bhavna Rani, Selina Möbus, Asha Balakrishnan, Jutta Lamle, Toni Cathomen, Arndt Vogel, Michael P. Manns, Michael Ott, Tobias Cantz, Amar Deep Sharma – 23 July 2012 – The tightly controlled replication of hepatocytes in liver regeneration and uncontrolled proliferation of tumor cells in hepatocellular carcinoma (HCC) are often modulated by common regulatory pathways. Several microRNAs (miRNAs) are involved in HCC progression by modulating posttranscriptional expression of multiple target genes.

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