Regulatory T cells control the CD8 adaptive immune response at the time of ductal obstruction in experimental biliary atresia

Celine S. Lages, Julia Simmons, Claire A. Chougnet, Alexander G. Miethke – 15 February 2012 – CD8 T‐lymphocytes are effector cells of cholangiocyte injury in human and in rhesus rotavirus (RRV)‐induced experimental biliary atresia (BA). Here we hypothesize that neonatal deficiency in CD25+CD4+ regulatory T cells (Tregs) leads to aberrant activation of hepatic T‐lymphocytes in BA.

Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha‐2a plus ribavirin

Stephen A. Harrison, Fayez M. Hamzeh, Jian Han, Prashant K. Pandya, Muhammed Y. Sheikh, John M. Vierling – 15 February 2012 – Patients with chronic hepatitis C and insulin resistance are less likely to respond to anti‐hepatitis C virus (HCV) therapy and are at risk for more rapid fibrosis progression. Coadministration of pioglitazone with peginterferon/ribavirin improves insulin sensitivity and increases virologic response rates in insulin‐resistant HCV genotype 4 patients, but it is unclear whether this finding applies to genotype 1 patients.

HCV RNA levels in a multiethnic cohort of injection drug users: Human genetic, viral and demographic associations

Lorenzo Uccellini, Fan‐Chen Tseng, Alessandro Monaco, Fatma M. Shebl, Ruth Pfeiffer, Myhanh Dotrang, Dianna Buckett, Michael P. Busch, Ena Wang, Brian R. Edlin, Francesco M. Marincola, Thomas R. O'Brien – 13 February 2012 – In patients with chronic hepatitis C, the hepatitis C virus (HCV) RNA level is an important predictor of treatment response. To explore the relationship of HCV RNA with viral and demographic factors, as well as IL28B genotype, we examined viral levels in an ethnically diverse group of injection drug users (IDUs).

Laser captured hepatocytes show association of butyrylcholinesterase gene loss and fibrosis progression in hepatitis C‐infected drug users

Supriya Munshaw, Hyon S. Hwang, Michael Torbenson, Jeffrey Quinn, Kasper D. Hansen, Jacquie Astemborski, Shruti H. Mehta, Stuart C. Ray, David L. Thomas, Ashwin Balagopal – 13 February 2012 – Chronic hepatitis C virus (HCV) infection is complicated by hepatic fibrosis. Hypothesizing that early fibrogenic signals may originate in cells susceptible to HCV infection, hepatocyte gene expression was analyzed from persons with chronic HCV at different stages of liver fibrosis.

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