Josh Levitsky, James M. Mathew, Michael Abecassis, Anat Tambur, Joseph Leventhal, Dhivya Chandrasekaran, Nancy Herrera, Patrice Al‐Saden, Lorenzo Gallon, Anmaar Abdul‐Nabi, Guang‐Yu Yang, Sunil M. Kurian, Daniel R. Salomon, Joshua Miller – 11 January 2012 – Immunosuppression (IS) withdrawal from calcineurin inhibitors is only possible in ∼20% of liver transplant recipients. However, mammalian target of rapamycin inhibitors (e.g., sirolimus; SRL) appear to be more immunoregulatory and might promote a tolerant state for withdrawal.

YuXiang Fang, Jing‐Lun Xue, Qi Shen, Jinzhong Chen, Ling Tian – 11 January 2012 – MicroRNAs (miRNAs) are known to be involved in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). Recently, microRNA‐7 (miR‐7) has been proven to play a substantial role in glioblastoma and breast cancer, but its functions in the context of HCC remain unknown. Here, we demonstrate that miR‐7 inhibits HCC cell growth and metastasis invitro and in vivo. We first screened and identified a novel miR‐7 target, phosphoinositide 3‐kinase catalytic subunit delta (PIK3CD).

Jin‐Hua Sun, Donald R. O'Boyle II, Yan Zhang, Chunfu Wang, Peter Nower, Lourdes Valera, Susan Roberts, Richard E. Nettles, Robert A. Fridell, Min Gao – 11 January 2012 – The influence of naturally occurring polymorphisms on the potency of the HCV nonstructural protein 5A (NS5A) replication complex inhibitor, BMS‐790052, was investigated by evaluating hybrid replicons in which the entire NS5A coding region of genotype (GT) la and 1b laboratory (lab) strains (H77c and Con1) were replaced with the corresponding regions of specimens collected from 10 GT‐1a‐ and 6 GT‐1b‐infected subjects.

Giuseppe Fede, Luisa Spadaro, Tania Tomaselli, Graziella Privitera, Giacomo Germani, Emmanuel Tsochatzis, Michael Thomas, Pierre‐Marc Bouloux, Andrew K. Burroughs, Francesco Purrello – 11 January 2012 – In patients with cirrhosis, adrenal insufficiency (AI) is reported during sepsis and septic shock and is associated with increased mortality. Consequently, the term “hepato‐adrenal syndrome” was proposed. Some studies have shown that AI is frequent in stable cirrhosis as well as in cirrhosis associated with decompensation other than sepsis, such as bleeding and ascites.

Clifford J. Steer, Subbaya Subramanian – 9 January 2012

Roberto I. Troisi, Mauricio Sainz‐Barriga – 4 January 2012

Nicholas A. Shackel – 4 January 2012

Elizabeth C. Verna, Rosa Valadao, Erica Farrand, Elsa M. Pichardo, Jennifer C. Lai, Norah A. Terrault, Robert S. Brown – 4 January 2012 – The ethnicity and socioeconomic status of the host may affect the progression of hepatitis C virus (HCV). We aimed to compare survival and fibrosis progression in Hispanic white (HW) and non‐Hispanic white (NHW) recipients of liver transplantation (LT) with HCV. All HW and NHW patients with HCV who underwent transplantation between January 2000 and December 2007 at 2 centers were retrospectively assessed.

Jayant S. Kalpoe, Edith Sonnenberg, Stephanie H. Factor, Juan del Rio Martin, Thomas Schiano, Gopi Patel, Shirish Huprikar – 4 January 2012 – Resistant bacterial infections are important causes of morbidity and mortality after liver transplantation (LT). This was a retrospective cohort study evaluating the outcomes associated with carbapenem‐resistant Klebsiella pneumoniae (CRKP) infections after LT. In a 2005‐2006 cohort of 175 consecutive LT recipients, 91 infection episodes were observed in 61 patients (35%). The mortality rate 1 year after LT was 18% (32/175).

Domingo Balderramo, Oriol Sendino, Marta Burrel, Maria Isabel Real, Annabel Blasi, Graciela Martinez‐Palli, Josep M. Bordas, Juan Carlos Garcia‐Valdecasas, Antoni Rimola, Miguel Navasa, Josep Llach, Andres Cardenas – 4 January 2012 – Anastomotic strictures (ASs) of the biliary duct after liver transplantation (LT) are primarily managed with endoscopic retrograde cholangiopancreatography (ERCP), but in some cases, this fails because of difficulties in passing the strictures.