Hacer Sahin, Erawan Borkham‐Kamphorst, Christoph Kuppe, Mirko Moreno Zaldivar, Christoph Grouls, Muhammad Al‐samman, Andreas Nellen, Petra Schmitz, Daniel Heinrichs, Marie‐Luise Berres, Dennis Doleschel, David Scholten, Ralf Weiskirchen, Marcus J. Moeller, Fabian Kiessling, Christian Trautwein, Hermann E. Wasmuth – 12 January 2012 – Recent data suggest that the chemokine receptor CXCR3 is functionally involved in fibroproliferative disorders, including liver fibrosis.

Lauren K. Dunn, Robert H. Thiele, Jennie Z. Ma, Robert G. Sawyer, Edward C. Nemergut – 12 January 2012 – Liver transplantation may be complicated by massive intraoperative bleeding, and red blood cell (RBC) transfusions may be required. The storage duration or age of transfused RBCs has been shown to affect the morbidity and mortality of critically ill, trauma, and cardiac surgery patients. Here we investigate the effect of RBC age on the outcomes of liver transplant patients.

Janett Fischer, Stephan Böhm, Markus Scholz, Tobias Müller, Heiko Witt, Jacob George, Christoph Sarrazin, Simone Susser, Eckart Schott, Vijayaprakash Suppiah, David R. Booth, Graeme J. Stewart, Florian van Bömmel, Annika Brodzinski, Balazs Fülöp, Pascal Migaud, Thomas Berg – 11 January 2012 – In patients with chronic hepatitis C virus (HCV) infection, several variants of the interleukin‐28B (IL28B) gene have been shown to correlate significantly with a sustained virologic response (SVR).

Wei Yan, Ying Chang, Xiaoyan Liang, Jon S. Cardinal, Hai Huang, Stephen H. Thorne, Satdarshan P.S. Monga, David A. Geller, Michael T. Lotze, Allan Tsung – 11 January 2012 – Hypoxia is often found in solid tumors and is associated with tumor progression and poor clinical outcomes. The exact mechanisms related to hypoxia‐induced invasion and metastasis remain unclear.

Jae Yeon Seok, Deuk Chae Na, Hyun Goo Woo, Massimo Roncalli, So Mee Kwon, Jeong Eun Yoo, Ei Yong Ahn, Gwang Il Kim, Jin‐Sub Choi, Young Bae Kim, Young Nyun Park – 11 January 2012 – Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major primary liver cancers in adults. The phenotypic overlap between HCC and CC has been shown to comprise a continuous liver cancer spectrum.

H. Carlijne Hassing, Hans Mooij, Shuling Guo, Brett P. Monia, Keyang Chen, Wim Kulik, Geesje M. Dallinga‐Thie, Max Nieuwdorp, Erik S.G. Stroes, Kevin Jon Williams – 11 January 2012 – Type 2 diabetes mellitus (T2DM) impairs hepatic clearance of atherogenic postprandial triglyceride‐rich lipoproteins (TRLs). We recently reported that livers from T2DM db/db mice markedly overexpress the heparan sulfate glucosamine‐6‐O‐endosulfatase‐2 (SULF2), an enzyme that removes 6‐O sulfate groups from heparan sulfate proteoglycans (HSPGs) and suppresses uptake of TRLs by cultured hepatocytes.

Lin Liu, Brian E. Fisher, David L. Thomas, Andrea L. Cox, Stuart C. Ray – 11 January 2012 – The aim of this study is to determine whether early viral dynamics and evolution predict outcome of primary acute hepatitis C virus (HCV) infection. HCV‐ and human immunodeficiency virus–negative injection drug users were enrolled prospectively and followed monthly to identify acute HCV infection using RNA detection. Subjects with more than 1 month between HCV‐RNA‐negative and ‐positive visits were excluded to ensure stringent acute infection.

Rachel Tanos, Rushang D. Patel, Iain A. Murray, Philip B. Smith, Andrew D. Patterson, Gary H. Perdew – 11 January 2012 – The aryl hydrocarbon receptor (AhR) is a ligand‐activated transcription factor. Activation of AhR mediates the expression of target genes (e.g., CYP1A1) by binding to dioxin response element (DRE) sequences in their promoter region.

Jing Shen, Shuang Wang, Yu‐Jing Zhang, Maya Kappil, Hui‐Chen Wu, Muhammad G. Kibriya, Qiao Wang, Farzana Jasmine, Habib Ahsan, Po‐Huang Lee, Ming‐Whei Yu, Chien‐Jen Chen, Regina M. Santella – 11 January 2012 – Alterations in DNA methylation frequently occur in hepatocellular cancer (HCC). We have previously demonstrated that hypermethylation in candidate genes can be detected in plasma DNA before HCC diagnosis.

Nassim Kamar, Florence Legrand‐Abravanel, Harry R. Dalton, Jacques Izopet – 11 January 2012