Serum C‐reactive protein is a useful biomarker for predicting outcomes after liver transplantation in patients with hepatocellular carcinoma

Ho Jung An, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Myung Ah Lee, Young Kyoung You, Dong Goo Kim, Eun Sun Jung – 23 July 2012 – Liver transplantation (LT) is a curative modality for hepatocellular carcinoma (HCC), especially in patients with cirrhosis. However, there are still risks of recurrence. C‐reactive protein (CRP), an acute‐phase inflammatory reactant that is synthesized by hepatocytes, has been related to the prognosis of various malignancies, including HCC.

Estrogen‐sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3

Jiajie Hou, Juan Xu, Runqiu Jiang, Youjing Wang, Chen Chen, Lei Deng, Xingxu Huang, Xuehao Wang, Beicheng Sun – 23 July 2012 – Protein tyrosine phosphatase receptor type O (PTPRO), one of the receptor types of phosphotyrosine phosphatases (PTP), was recently described as a tumor suppressor in various kinds of cancers. We aimed to clarify the role of PTPRO in hepatocellular carcinoma (HCC).

High‐mobility group box 1 (HMGB1)‐toll‐like receptor (TLR)4‐interleukin (IL)‐23‐IL‐17A axis in drug‐induced damage‐associated lethal hepatitis: Interaction of γδ T cells with macrophages

Xuefu Wang, Rui Sun, Haiming Wei, Zhigang Tian – 23 July 2012 – Acetaminophen overdose causes acute liver inflammation with neutrophil infiltration; however, the mechanism of damage‐associated inflammation has not been elucidated. In this study we found that the HMGB1‐TLR4‐IL‐23‐IL‐17A axis played a crucial role in acetaminophen‐induced infiltration of neutrophils and liver injury. Notably, interleukin (IL)‐17A and IL‐23 significantly increased after acetaminophen challenge.

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