A C‐terminal tyrosine‐based motif in the bile salt export pump directs clathrin‐dependent endocytosis

Ping Lam, Shuhua Xu, Carol J. Soroka, James L. Boyer – 12 December 2011 – The liver‐specific bile salt export pump (BSEP) is crucial for bile acid–dependent bile flow at the apical membrane. BSEP, a member of the family of structurally related adenosine triphosphate (ATP)‐binding cassette (ABC) proteins, is composed of 12 transmembrane segments (TMS) and two large cytoplasmic nucleotide‐binding domains (NBDs).

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